Using the Cre-deletor strain Hoxb7-Cre, Washington University researchers developed transgenic mice with loxP sites flanking the gene for the glial cell line-derived neurotrophic factor (GDNF) family receptor α1 (GFRα1), which is involved in kidney tissue development. These mice were then used to determine the role of GFRα1 in the development of different cell types and in different stages of development.

Publication: Stage specific requirement of Gfrα1 in the ureteric epithelium during kidney development