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Potentiator that Enhances Mucociliary Transport to Treat Cystic Fibrosis and other Mucus Obstructive DiseasesSala-Rabanal, Monica ; Yurtsever, Zeynep ; Berry, Kayla ; Miller, Mark ; Nichols, Colin ; Alexander-Brett, Jennifer ; Brett, Thomas
T-021341
— Published date: 6/3/2026 Value Proposition: Using CLCA1 VWA to specifically potentiate TMEM16A to enhance mucociliary transport in cystic fibrosis and other mucus obstructive diseases. Technology Description Researchers at Washington University in St. Louis have developed a potentiator, CLCA1 …
Disease-Modifying ASO Therapy for Mitchell Syndrome and ObesitySchoch, Kathleen ; Hubler, Zita ; Bucelli, Robert ; Miller, Timothy
T-021317
— Published date: 6/2/2026 Value Proposition: First-in-class antisense oligonucleotide (ASO) therapy selectively lowering ACOX1 to enable disease-modifying treatment of Mitchell Syndrome and unlocking a metabolic shift facilitating weight loss. Technology Description: Mitchell Syndrome is an u…
Method for Mobilizing Hematopoietic Stem Cells Using VLA4 InhibitorsRettig, Michael ; DiPersio, John ; Ruminski, Peter
T-019410
— Published date: 6/2/2026 Value Proposition: VLA4 inhibitors that significantly mobilize hematopoietic stem cells from bone marrow. Technology Description Researchers at Washington University in St. Louis have developed novel VLA4 inhibitors for mobilizing hematopoietic stem cells in peripheral …
Novel Cell Therapy Platform for Cancer using Engineered cDC1 Dendritic CellsDeSelm, Carl
T-019199
— Published date: 6/2/2026 Value proposition: CAR-engineered cDC1 cells (syngeneic or allogeneic) that stably express a proprietary, modular chimeric antigen receptor and demonstrate strong in vivo efficacy against solid tumors, including immunologically ‘cold’ tumors. Technology Desc…
A Novel Echocardiographic Parameter for Dynamic Assessment of Diastolic Function in Acute Heart FailureMay, Adam ; Davis, John
T-021708
— Published date: 5/30/2026 Value Proposition: Doppler-derived parameter that can account for the preload condition dependency of diastolic function in acute heart failure. Technology Description Researchers at Washington University in St. Louis have developed and validated the Dynamic Diastolic L…
Novel Cell Therapy Platform for Cancer using Engineered cDC1 Dendritic CellsNamen, Shelby ; Pandey, Gaurav ; DeSelm, Carl
T-020903
— Published date: 5/30/2026 Value Proposition: CAR-engineered cDC1 cells (syngeneic or allogeneic) that stably express a proprietary, modular chimeric antigen receptor and demonstrate strong in vivo efficacy against solid tumors, including immunologically ‘cold’ tumors. Technology Descr…
Kidney Disease Biomarkers for Diagnosis, Prognosis or Clinical Trials MonitoringKim, Yeawon ; Chen, Ying
T-016375
— Published date: 5/29/2026 Value Proposition: Urine-based biomarkers that can be used for early detection and diagnosis of kidney disease non-invasively. Technology Description Researchers at Washington University in St. Louis have identified three sensitive, urine-based biomarkers of kidney di…
Techniques to Measure Nephron Number in the Kidney In VivoBaldelomar, Edwin ; Bennett, Kevin
T-021632
— Published date: 5/23/2026 Value Proposition: Method that uses non-contrast MRI to measure nephron number for individualized assessment of kidney functional capacity. Technology Description Researchers at Washington University in St. Louis have developed a method of using non-contrast MRI to d…
Novel Sulfated Neurosteroid Molecules for Treating Migraines and PainMennerick, Steven ; Zorumski, Charles ; Evers, Alex ; Covey, Douglas
T-021437
— Published date: 5/23/2026 Value Proposition: Steroidal trifluoromethyl ketone modulators of GABA-A and NMDA receptors for treating migraine, headache, and pain. Technology Description Clinical and scientific experts in modulating GABA-A and NMDA receptors at Washington University in St. Louis…
Peptide Functionalized Viscoelastic Hydrogels for Scalable hiPSC Cardiac DifferentiationHashemi, Mohammad ; Huebsch, Nathaniel
T-021813
— Published date: 5/23/2026 Value Proposition: Hydrogel platform that enables scalable production of cardiomyocytes Technology Description Researchers at Washington University in St. Louis have developed a chemically defined, tunable hydrogel platform that improves the production of human induce…
New Composition of Matter that can be used to Treat Multidrug Resistant InfectionsXue, Yao-Peng ; Dantas, Gautam ; Li, Ruihao ; Wencewicz, Timothy
T-021458
— Published date: 5/23/2026 Value Proposition: Covalent mechanism-based inhibitors of tetracycline destructases for treating infectious diseases. Technology Description Researchers at Washington University in St. Louis have developed a group of C9-modified anhydrotetracyclines that inhibit tetra…
Inhibition of E. coli Hemolysin During Urinary Tract InfectionsMa, Hongming ; Diamond, Michael ; Kuhn, Hunter ; Hunstad, David
T-020923
— Published date: 5/20/2026 Value Proposition: Potential adjunctive therapy for E. coli pyelonephritis to mitigate the renal tissue damage associated with infection, thereby reducing renal scarring and other long-term complications of renal scarring. Technology Description Researchers at Washingt…
System for Sonogenetic Control of Islet Organoids Function for Type 1 Diabetes TreatmentChen, Hong ; Cui, Jianmin
T-020579
— Published date: 5/13/2026 Value Proposition: Non-invasive stimulation strategy that can deliver dynamic glycemic control to treat Type 1 diabetes. Technology Description Researchers at Washington University in St. Louis have developed Acoustic-Controlled Insulin Secretion (ACIS), a novel sono…
System for Sonogenetic Control of Islet Organoids Function for Type 1 Diabetes TreatmentCui, Jianmin
T-021674
— Published date: 5/13/2026 Value Proposition: Non-invasive stimulation strategy that can deliver dynamic glycemic control to treat Type 1 diabetes. Technology Description Researchers at Washington University in St. Louis have developed Acoustic-Controlled Insulin Secretion (ACIS), a novel sono…
Diagnostic and Biomarker for Treating Atopic Dermatitis (AD)Mack, Madison ; Brestoff Parker, Jonathan ; Kim, Brian
T-018984
— Published date: 4/21/2026 Value Proposition: IL-15 superagonist that utilizes a companion diagnostic to treat atopic dermatitis. Technology Description Researchers at Washington University in St. Louis have developed a treatment strategy for atopic dermatitis that uses an IL-15 superagonist, al…
Therapy Method that Uses Long Non-Coding RNA and CDK4/6 Inhibitors to Treat Breast CancerMishra, Richa ; Silva-Fisher, Jessica
T-021352
— Published date: 4/18/2026 Value Proposition: Combination cancer therapy that utilizes long non-coding RNA and CDK4/6 inhibitors to treat breast cancer. Technology Description Researchers at Washington University in St. Louis have developed a cancer combination therapy using CDK4/6 inhibitors an…
Bedside Noninvasive Imaging Test to Assess Kidney FunctionBaldelomar, Edwin ; Bennett, Kevin
T-021392
— Published date: 4/18/2026 Value Proposition: Method that uses ultrasound to detect functional nephron number in the kidneys. Technology Description Current clinical markers of kidney health (serum creatinine and estimated glomerular filtration rate (eGFR)) are insensitive to the early progressi…
Method for Rapid Thermoforming and Design Iteration of Bespoke Polycarbonate Tissue Culture DevicesMalayath, Ganesh ; Huebsch, Nathaniel
T-021529
— Published date: 4/4/2026 Value Proposition: Rapid thermoforming process that can produce custom, low-cost devices for cell culture that are compatible with common cell culture techniques. Technology Description Researchers at Washington University in St. Louis have developed a process where for…
New Strategy for Treatment of Neurodegenerative Diseases with AxonopathyMilbrandt, Jeffrey ; Summers, Daniel ; Geisler, Stefanie ; Mao, Xianrong ; DiAntonio, Aaron
T-017543
— Value Proposition: This invention uses a novel gene therapy that blocks the axon degeneration typical of neurodegenerative diseases. Technology Description Researchers at Washington University in St. Louis have developed a new strategy for treatment of neurodegenerative diseases with axonopathy.…
NuPanc – A Sustainable Cure for Chronic DiabetesMillman, Jeffrey ; Zayed, Mohamed
T-016290
— Published Date: 6/12/2025 Value Proposition: Novel vascular graft device that delivers whole pancreatic islets to enhance glycemic control and chronic management of diabetes, without the need for immunosuppression. Technology Description Researchers at Washington University in St. Louis have de…
