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Transmembrane Protein Targeted to Treat Obesity and Associated Metabolic DiseasesJia, Wentong ; Diamond, Michael ; Brestoff Parker, Jonathan
T-020807
— Value Proposition: This invention targets MXRA8 protein as a therapy for obesity and other metabolic diseases. Technology Description Researchers at Washington University in St. Louis have developed an MXRA8 targeted therapeutic to treat obesity and associated metabolic diseases. MXRA8 is the re…
Small Molecule Gastrin-releasing peptide receptor (GRPR) antagonists used for Anti-Itch TreatmentDolle, Roland "Ron" ; Zhou, Mingzhou
T-020002
— Value Proposition: Small molecule Gastrin-releasing peptide receptor (GRPR) antagonists used to treat chronic itch. Technology Description Researchers at Washington University in St. Louis have discovered a group of small molecule Gastrin-releasing peptide receptor (GRPR) antagonists to treat c…
Intraoperative Mapping Tool for Identifying Functional Brain Areas in Anesthetized PatientsBreshears, Jonathan ; Leuthardt, Eric
T-010379
— Value Proposition: New technique for examining active brain areas in unconscious neurosurgical patients. Technology Description Researchers at Washington University in St. Louis have developed a new process that includes a new use for existing electrocorticographic (ECoG) grids, an amplifier, an…
Method To Remove Brain Stimulation Artifacts in Neural SignalsWillie, Jon ; Xie, Tao ; Leuthardt, Eric ; Brunner, Peter
T-020083
— Value proposition: Method and system for removing multiple types of brain stimulation artifacts in neural signals to improve neurological diagnoses and therapies. Technology Description Researchers at Washington University in St. Louis have developed a method to remove brain stimulation artifact…
Method to Perform Spectral Biopsy of Electrophysiological Brain Function for use in Monitoring and Diagnosing Neurological ConditionsLeuthardt, Eric ; Brunner, Peter
T-019651
— Value Proposition: New process used to detect/measure the intrinsic neuronal brain activity to diagnose neurological and psychiatric diseases. Technology Description Researchers at Washington University in St. Louis have developed a method called Tau-Modulation to assess intrinsic neuronal activi…
Real-time 3D MRI for use in Diagnostic MRI and MRI-guided RadiotherapyPark, Chunjoo (Justin) ; Kim, Taeho
T-019011
— Value Proposition: Method combines two previously known techniques to enable real time 3D MRI image reconstruction for improving patient care. Technology Description Researchers at Washington University in St. Louis have developed a method for real-time, high-resolution 3D MRI that can be used i…
Engineered Polymer-Peptide for Treatment of Lower Back Pain Caused by Chronic Back PainSpeer, Julie ; Barcellona, Marcos ; Setton, Lori
T-019297
— Value Proposition: Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating back pain. Technology Description Researchers at Washington University in St. Louis have developed an engineered peptide-functionalized polymer that can support healthy nucle…
Iris-Sealing Mask for the Mitigation of the Spread of Patient Aerosols Undergoing Intubation, Extubation, and Respiratory SupportCashin, John ; Zayed, Mohamed
T-020364
— Value Proposition: Masking device designed to provide protection for healthcare professionals from the spread of respiratory droplets during the extubation, intubation, and ongoing respiratory support of patients. Technology Description Researchers at Washington University in St. Louis have dev…
Sutureless Device for Connecting Vessels End-to-SideCashin, John ; Zayed, Mohamed
T-020365
— Value Proposition: Simple device that allows for sutureless end-to-side surgical anastomosis of vessels. Technology Description Researchers at Washington University in St. Louis have developed a device which facilitates the sutureless end-to-side anastomosis of vessels. The TAPV device may be …
Method that Uses Taurine as a Storage Supplement for Platelet ConcentratesSpinella, Philip ; Shea, Susan ; Thomas, Kimberly
T-019841
— Value Proposition: Composition of matter that uses taurine to improve cold platelet storage shelf life and functionality. Technology Description Researchers at Washington University in St. Louis have developed a method to cold store platelets using taurine supplementation. There is a crucial ne…
Novel Software to Increase the Accuracy of Proton TherapyMedrano, Maria ; O'Sullivan, Joseph ; Zhao, Tianyu ; Chen, Xinyuan ; Williamson, Jeffrey
T-020198
— Technology Description Developed by researchers in the Williamson and O’Sullivan Labs at the Washington University in St. Louis, this technology is a novel software platform that creates more accurate proton beam targeting to tumors. The software is used during proton therapy treatment plann…
Treatment of COVID-19 Using Fluvoxamine MaleateLenze, Eric ; Reiersen, Angela
T-019712
— Value Proposition: Novel method for treating short- and long-term symptoms of COVID-19 using a selective serotonin reuptake inhibitor (SSRI) and a sigma-1 receptor (S1R) agonist. Technology Description Researchers at Washington University in St. Louis have developed a novel method for treating …
Candidate Probiotic Strains for Improving Infant Health T-020134 & T-019665Chang, Hao-Wei ; Hibberd, Matthew ; Wang, Yi ; Webber, Daniel ; Barratt, Michael ; Gordon, Jeffrey
T-020134
— Value Proposition: Human microbe strains with robust colonization efficacy and potent in vivo harvesting of beneficial metabolites involved in infant health. Technology Description Researchers from the laboratory of Dr. Jeffrey Gordon at Washington University in St. Louis have discovered str…
Treatment of Chronic Pruritus through Intranasal or Intrathecal Delivery of Ruxolitinib or Tofacitinib (JAK inhibitors)Kim, Brian
T-015992
— Value proposition: Novel approach to treat chronic itch through the intrathecal or intranasal delivery of JAK inhibitors. Technology Description Researchers at Washington University in St. Louis have developed a new method for treating chronic idiopathic pruritus (CIP) in both patients and m…
T-020639 Using Fluorescence Lifetime to Measure Neuromodulator Dynamics Over Transient and Chronic Time ScalesMa, Pingchuan ; Chen, Yao
T-020639
— Technology Description Researchers at Washington University in St. Louis have developed a novel method that uses fluorescence lifetime to simultaneously record, and measure neuromodulator change over transient and chronic time scales, promising to reveal the roles of multi-time scale neuromodulato…
Novel PET/SPECT Radiopharmaceutical for Improving Biomedical ImagingSivapackiam, Jothilingam ; Piwnica-Worms, David ; Sharma, Vijay
T-010438
— Technology Description Researchers at Washington University in St. Louis have developed a novel positron emission tomography (PET) radiopharmaceutical for myocardial perfusion imaging. Myocardial perfusion scintigraphy is widely employed in the evaluation of patients with heart disease. Several ag…
Software used to Detect Neural Oscillations in the Time-Frequency SpaceCho, Hohyun ; Brunner, Peter
T-020025
— Technology Description Researchers at Washington University in St. Louis have developed a software method that demonstrates high precision and specificity in detecting neural oscillations in time and frequency domains. Current methods to look at identifying peaks over 1/f noise within the power s…
Highly Accurate Model used to Predict Alzheimer’s Disease StatusAli, Muhammad ; Cruchaga, Carlos
T-020673
— Technology Description Researchers at Washington University in St. Louis have developed models that can very accurately predict brain amyloidosis—Alzheimer’s disease status. Alzheimer’s disease (AD) is characterized by the accumulation of Amyloid-β (Aβ42) and hyperphos…
Novel Bile Acids as Biomarkers for Early Detection of Niemann-Pick Type C DiseaseJiang, Xuntian ; Ory, Daniel
T-014292
— Technology Description Researchers at Washington University in St. Louis have developed a set of novel bile acid biomarkers to screen, diagnose, and monitor the progression of Niemann-Pick type C (NPC) disease. Current testing for this disease takes an average of three months, is invasive (a skin…
Optimizing Patient Treatment through Electrical Stimulation for Targeted Deep Brain StimulationWillie, Jon ; Leuthardt, Eric ; Adamek, Markus ; Brunner, Peter
T-020028
— Technology Description Researchers at Washington University in St. Louis have developed a deep brain stimulation approach that can identify optimal stimulation parameters intraoperatively, which significantly reduces the amount of time spent on adapting stimulation parameters, thus reducing costs,…
