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Inflammatory bowel disease biomarkers and therapeutic target
Liu, Ta-Chiang ; Kaiko, Gerard ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Automated image processing tools for quantitative SPECT and PET scans
Rahman, Md Ashequr ; Yu, Zitong ; Moon, Hae Sol ; Liu, Ziping ; Jha, Abhinav Kumar
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Low cost, versatile enzymatic synthesis of beta-lactone peptides for antibiotic or serine hydrolase inhibitor drug discovery
Schaffer, Jason ; Reck, Margaret ; Wencewicz, Timothy
T-016508

— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…

Rapid, accurate RT-PCR test for enterovirus D68
Wylie, Todd ; Wylie, Kristine ; Storch, Gregory
T-015155

— Technology Description A team of researchers at Washington University designed patented primers for a sensitive, specific, real-time reverse transcriptase PCR (RT-PCR) assay to quickly detect enterovirus D68 (EV-D68). EV-D68 is an emerging, highly contagious respiratory virus that can cause seve…

Monoclonal antibodies against pSer784-VCP
Shao, Jieya
T-019491

— VCP is an essential AAA+ ATPase that regulates proteostasis under normal and stressed cellular conditions. These monoclonal antibodies specifically recognize pSer784-VCP, which is phosphorylated during the DNA damage response and plays a crucial role in cellular survival upon genotoxic chemotherapy …

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

In vivo editing via targeted adenoviral vectors
Curiel, David
T-016332

— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…

Low-cost optical sensors for high performance, discrete hearing aids
Liao, Jie ; Yang, Lan
T-019167

— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…

Treatment for chronic migraines
Zhang, Jintao ; Zhang, Zhiyu ; Hu, Rong ; Cloud, Megan ; Cao, Yu-Qing
T-018942

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…

Flag tagged BK(MDAL) in pBUD mch
Lorca, Ramon ; England, Sarah
T-019344

— Plasmid for flag tagged BK(MDAL) in a pBUD mcherry vector.

Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and research
Morrissey, Jeremiah ; Tian, Limei ; Kharasch, Evan ; Liu, Keng-Ku ; Abbas, Abdennour ; Singamaneni, Srikanth
T-013772

— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Morrissey, Jeremiah ; Wang, Congzhou ; Kharasch, Evan ; Singamaneni, Srikanth
T-016668

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Gupta, Rohit ; Chakrabartty, Shantanu ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Mouse Anti-Human PLD3 (Phospholipase D3) antibody HJ16.6
Holtzman, David
T-019280

— Anti-human hPLD3 antibody raised in mice. The antibody isotype is islgG2b.

Clifednamide compounds
Yang, Jinping ; Van Dyke-Blodgett, Joshua ; Qi, Yunci ; Wencewicz, Timothy
T-019321

— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value. Publication: Qi, Y., Ding, E., & Blodget…

hNALCN Promoter-PGL3 Basic Luc Plasmid
Amazu, Chinwendu ; England, Sarah
T-019342

— The promoter region of the NALCN, sodium leak current, was amplified and inserted into the PGL3 Basic Luc backbone. The plasmid has applications in studying interactions of transcription factors with NALCN.

CD36 floxed mice
Abumrad, Nada
T-019340

— Mouse line with CD36 floxed allele. CD36 is a multifunctional glycoprotein that acts as receptor for a broad range of ligands. The CD36 flox mice were generated using a BAC with a 1.7kb sequence with exons 3 and 4. Publication: Endothelial cell CD36 optimizes tissue fatty acid uptake

IL-33 mCherry Mice
Joshita, Satoru ; Gilfillan, Susan ; Colonna, Marco
T-019315

— Reporter mouse line that allows for identification of cells productive IL-33 through mCherry expression. IL-33 is a molecule involved in immune system responses to helminths, allergies, and asthma. Publications:

IL33 tm1b and tm1c
Yoshita, Satoru ; Gilfillan, Susan ; Colonna, Marco
T-019314

— The Colonna lab generated two IL-33 knockout mouse lines – a total and a conditional knockout models. IL-33 is a crucial mediator of inflammation. Publication: IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation

IL34 tm1b and tm1c mice
Wang, Yaming ; Gilfillan, Susan ; Colonna, Marco
T-019313

— Mouse line knockouts of IL-34. IL-34 is a growth factor for macrophages, microglia, and Langerhans cells, among others. Publication: IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia