— Technology Description A team of researchers at Washington University designed patented primers for a sensitive, specific, real-time reverse transcriptase PCR (RT-PCR) assay to quickly detect enterovirus D68 (EV-D68). EV-D68 is an emerging, highly contagious respiratory virus that can cause seve…
— VCP is an essential AAA+ ATPase that regulates proteostasis under normal and stressed cellular conditions. These monoclonal antibodies specifically recognize pSer784-VCP, which is phosphorylated during the DNA damage response and plays a crucial role in cellular survival upon genotoxic chemotherapy …
— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…
— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…
— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…
— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…
— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value. Publication: Qi, Y., Ding, E., & Blodget…
— The promoter region of the NALCN, sodium leak current, was amplified and inserted into the PGL3 Basic Luc backbone. The plasmid has applications in studying interactions of transcription factors with NALCN.
— Mouse line with CD36 floxed allele. CD36 is a multifunctional glycoprotein that acts as receptor for a broad range of ligands. The CD36 flox mice were generated using a BAC with a 1.7kb sequence with exons 3 and 4. Publication: Endothelial cell CD36 optimizes tissue fatty acid uptake
IL-33 mCherry Mice Joshita, Satoru ; Gilfillan, Susan ; Colonna, Marco
T-019315
— Reporter mouse line that allows for identification of cells productive IL-33 through mCherry expression. IL-33 is a molecule involved in immune system responses to helminths, allergies, and asthma. Publications:
IL33 tm1b and tm1c Gilfillan, Susan ; Yoshita, Satoru ; Colonna, Marco
T-019314
— The Colonna lab generated two IL-33 knockout mouse lines – a total and a conditional knockout models. IL-33 is a crucial mediator of inflammation. Publication: IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation
— Mouse line knockouts of IL-34. IL-34 is a growth factor for macrophages, microglia, and Langerhans cells, among others. Publication: IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
— Stable zebrafish line that shows calcium signaling within the pancreatic beta cells. The line was generated using the calcium sensing fluorophore gCAMP and integrated using the TOL2 transcription factor. Publication: Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets
— Dr. Dougherty developed a collection of mouse lines with deletions of Gft2i and Gtfird1 in various combinations. The genes are related to Williams Beuren locus. Publications:
— Collagen antibodies that bind to the major collagen IV component of the kidney glomerular basement membrance. The antbiodies reaction with mouse, rat, and human chains and were derived using the noncollagenous NCI domains at the COOH-termini in rabbit antiserum to mouse. Collagen IV alpha3 chain: 353 Collagen IV alpha4 chain: 356 Collagen IV alpha5 chain: 358
— Mouse line carrying a mutation in Col4a3 backcrossed to 129S1/Sv1mJ strain. The mice show kidney failure at 10-12 weeks of age to enable rapid drug screening. Publication: A mouse collagen4α4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trime…
