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S1P1-targeted PET tracersYue, Xuyi ; Rosenberg, Adam ; Liu, Hui ; Tu, Zhude "Will"
T-016151
— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…
S1PR2-targeted PET tracersLiu, Hui ; Luo, Zonghua ; Klein, Robyn ; Tu, Zhude "Will"
T-018580
— Technology Description Researchers at Washington University in St. Louis and colleagues have developed S1PR2-targeted PET tracers. Sphingosine-1-phosphate (S1P) is an important bioactive lipid that regulates critical biological functions by acting through five specific G protein-coupled S1P recept…
Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tearsSmith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan ; Hoppe, Ethan ; Galatz, Leesa ; Genin, Guy
T-019211
— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…
pBAD.dCas9sth1.pAL5000 plasmidMoon, Tae Seok
T-018499
— A plasmid constuct containing the Streptococcus thermophilus dCas9 (dCas9sth 1) gene under the control of the arabinose inducible pBAD promoter and a constitutively expressed single guide RNA (sgRNA) on the pAL5000 vector backbone. Publication: Molecular Toolkit for Gene Expression Control and Geno…
F-18 radiotracer for alpha-synucleinTu, Zhude "Will"
T-018513
— These materials are an alpha-synuclein binding compound (standard), and the precursor for PET radiolabeling the compound. Precursor’s code name: TZ61-23; chemical name: 2-((6-methoxypyridin-3-yl)amino)quinolin-6-ol. Standard’s code name: TZ61-44; chemical name: 6-(2-fluoroexthoxy)-N-(6-metho…
αB-crystallin (cryAB) R120G mutant knock-in miceAndley, Usha
T-018700
— Researchers developed these knock-in mice by using homologous recombination to clone the R120G mutation into exon 3 of the αB-crystallin gene (cryab). αB-crystallin (cryAB) helps to maintain protein stability in the eye lens, which is necessary for transparency. The R120G mutation causes…
Cas9-based plasmids for engineering Synechocystis sp. PCC 6803 cyanobacteriaZhang, Fuzhong
T-018507
— These plasmids were developed by Washington University researchers as tools for genetically engineering Synechocystis sp. PCC 6803 (S6803), a model cyanobacterium used commonly in research and biotechnology applications. Because S6803 is polyploid, genetic modification of this strain typically requi…
Methods to Treat Vasodilatory Septic ShockBoyle, Walter
T-007528
— Background: Vasodilatory shock, a reduction in effective blood circulation, occurs when endogenous vasoconstrictor mechanisms fail as a result of an often lethal combination of severe infections. Sepsis, as one of the causes, alone affects 1 million people resulting in more than 258,000 deaths each …
Plasmids with genetic variants of CELXiao, Xunjun ; Lowe, Mark
T-018959
— These plasmids encode carboxyl ester lipase (CEL) with and without genetic variants that are associated with chronic pancreatitis. To make the plasmids, the researchers used a full-length human CEL cDNA clone. The cDNA encoded for a 14-repeat VNTR, the variant present in the CEL MODY family. The Ec…
DH1, DH1(tesA) & BC33 – E. coli strains for producing branched-chain fatty acidsZhang, Fuzhong
T-017808
— CL111 was first transformed with the plasmids containing BCFA-producing pathway. The straight-chain-specific fabH was then eliminated by phage P1 transduction with lysates grown on strain CAG12094. The transduction mixtures were plated on LB-agar medium supplemented with appropriate anti-biotics (te…
Recombinant Alpha-synuclein monomer and fibrils produced from Recombinant Alpha-synuclein monomerKotzbauer, Paul
T-017809
— Alpha synuclein is a 140 amino acid protein. The accumulation of aggregated alpha-synuclein within neuronal cells is the defining pathologic change in Parkinson’s disease. We produced recombinany human alpha-synuclein protein in E. Coli and purified it. We developmed an incubation procedure unde…
Adenovirus: Ad-GFP-LC3, Ad-FLAG-BNIP3, Ad-mBECLIN-1, Ad-Parkin(HA), Ad-TRAF2(FLAG), Ad-TRAF2-Rm, Ad- TRAF2-deltaN. Plasmids: mCherry-GFP-LC3, DsRed-BNIP3, GFP-Parkin, GFP-LC3, DsRed-monomer-GFP fusion positive controlDiwan, Abhinav
T-017834
— Adenoviruses were generated using the Invitrogen Virapower system, which uses Clonase mediated recombination. They were generated in HEK293A cells and titered per the manufacturer’s instructions. Publications: Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death; Impaired …
pTet-T – A plasmid for chromosomal integration of pTet-fbfp & kanamycin antibiotic resistance into Synechocystis sp. PCC6803Moon, Tae Seok
T-017841
— The plasmid was constructed in E. coli DH10B which was grown in LB at 37°C and 250 rpm in 14 mL BD FalconTM round‐bottom tubes. Kanamycin (kan) (20 µg/mL) and spectinomycin (spec) (100 µg/mL) were added as appropriate. Plasmids were constructed using the…
MOG.15 hybridomaWu, Gregory
T-017899
— MOG.15 is a T cell hybridoma that will be active when engaged with an antigen presenting cell that is presenting MOG35-55 peptide. Publication: Conditional MHC Class II Expression Reveals a Limited Role for B Cell Antigen Presentation in Primary and Secondary CD4 T Cell Responses
Bacterial Strains isolated from fecal samplesGordon, Jeffrey
T-017911
— Cultured and sequenced bacterial strains isolated from fecal samples. The samples were collected from the Bill and Melinda Gates Foundation sponsored studies of childhood undernutrition in Bangladesh.
Neural interface device for complex, specific stimulation of peripheral nervesMacEwan, Matthew ; Christiansen, Blaine ; Moran, Daniel
T-007621
— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…
ACALADE: surgical device designed for faster, safer lumbar discectomyStoev, Ivan ; Wright, Neill ; Moran, Daniel ; Reynolds, Benton ; Johnson, Tim ; Leuthardt, Eric
T-016236
— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…
Radium Chelation For Targeted Alpha Particle TherapyAbou, Diane ; Thorek, Daniel
T-019039
— Technology Description Researchers at Washington University in St. Louis have developed a method to chelate radium-223 and increase its utility in targeted alpha-particle therapy (TAT). TAT aims to deliver cytotoxic alpha-particles to cancer cells. Radium-223 is an alpha particle emitting isotope …
EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractionsWang, Yong ; Schwartz, Alan ; Cahill, Alison ; Cuculich, Phillip
T-015805
— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…
Synthetic Dendritic Cells for Expanding Antigen-Specific T Cells used in Cancer ImmunotherapySarker, Bapi ; Klechevsky, Eynav ; Pathak, Amit
T-017391
— Technology Description: A team led by Drs. Amit Pathak and Eynav Klechevsky have developed a soft alginate-gelatin matrix-based synthetic dendritic cell to rapidly expand and deliver CD8+ T cells for cancer immunotherapy. CD8+ T cells kill tumors, but current methods to expand them also activate r…
