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TR3: a stabilized TRAIL timer for use as an anticancer therapeuticHotchkiss, Richard ; Hawkins, William ; Spitzer, Dirk
T-007646
— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…
Mesothelin-TR3: targeted TRAIL trimers with superior anticancer activityHawkins, William ; Spitzer, Dirk
T-011885
— WUSTL Technology 011885 Technology Description Researchers at Washington University in St. Louis have developed a strategy to specifically target the anticancer therapeutic TR3 to cancer cells using the mesothelin/MUC16 interaction. Mesothelin is a GPI linked cell surface protein expressed in mes…
scFv-TR3: TRAIL trimers targeted to mesothelinHawkins, William ; Spitzer, Dirk
T-016481
— WUSTL Technology 016481 Technology Description Researchers at Washington University in St. Louis have developed an additional targeting strategy to provide more flexibility and improve the bioactivity of the anticancer therapeutic TR3. This strategy targets TR3 to mesothelin, a tumor biomarker fr…
Vaccine to prevent catheter-associated urinary tract infectionPinkner, Jerome ; Flores-Mireles, Ana ; Caparon, Michael ; Hultgren, Scott
T-013965
— Technology Description Researchers at Washington University in St. Louis have developed a vaccine strategy to prevent catheter-associated urinary tract infections (CAUTIs). CAUTIs are the most common cause of hospital-acquired infections. Many of these are caused by Enterococcus bacteria. CAUTIs a…
Use of ent-allopregnanolone to treat glaucomaZorumski, Charles ; Izumi, Yukitoshi ; Covey, Douglas
T-018940
— Technology Description Researchers from Washington University in St. Louis and colleagues have identified ent-allopregnanolone (ent-AlloP) as a potential therapeutic to treat glaucoma. Glaucoma, the leading cause of irreversible blindness, results from damage to the retinal ganglion cells (RGSs) t…
Mouse Hybridoma producing IgG3 Antibodies against Human TIGIT (WUCAM)Boles, Kent ; Colonna, Marco
T-008862
— Target: T Cell Immunoreceptor with Ig and ITIM domains, a.k.a. WUCAM Notes: Clone available is 4E1.2. Used in flow cytometry and functional studies.Mouse IgG3 was generated by immunizing BALB/c mice with WUCAMFLAG-Baf3 cells. This can be used to study T cell-dependent antibody responses. Publication: A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC
Rat Hybridoma producing IgG1 Monoclonal Antibodies to Mouse CD96Colonna, Marco
T-010940
— Target: Cluster of Differentiation 96 protein. Notes: Clone available is 3.3.1We generated the mAb 480.1 anti – mouse DNAM-1 (mDNAM-1) or mAb 3.1 anti – mouse CD96 (mCD96) by immunizing rats with RBL cells transfected with mDNAM-1 cDNA (RBL – mDNAM-1) or mouse CD96 cDNA (RBL-mCD96) and selecting hybridomas that reacted with 293 – mDNAM-1 or 293-mCD96 t…
Monoclonal Antibodies to Enterococcus Faecalis Secreted ProteinsShaikh, Nurmohammad ; Tarr, Phillip
T-011162
— Target: SalB (mAb 6H3) Notes: Reduces inflammatory response.We have identified and characterized monoclonal antibodies that recognize secreted proteins of Enterococcus faecalis, and that neutralize the abilities of whole, viable, E. faecilis to stimulate a pro-inflammatory cytokine in cultured epithelial cells. The monoclonal antibodies are directed against …
CemOrange2 gene fusions for subcellular imaging in C. elegansThomas, Brian ; Silverman, Gary ; Pak, Stephen ; Luke, Clifford
T-018982
— Plasmids were generated with the NHX-2 promoter, to restrict gene expression to the C. elegans intestinal cells, driving C. elegans genes or targeting peptides, known to target different subcellular organelles, fused to a C. elegans optimized mOrange2 fluorescent protein (CemOrange2). These expressi…
Hybridoma Cell Lines SAG1 and MIC2Sibley, Laurence
T-018970
— 2 murine hybridoma cell lines producing antibodies agains Toxoplasma gondii proteins SAG1 and MIC2 SAG1 (DG52) publication: Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii MIC2 (6D10) publication: The Toxoplasma Adhesive Protein MIC2 Is Proteolytically Proces…
Toxoplasma strainsSibley, Laurence
T-018972
— The inventors have generated multiple gene knockout strains of T. gondii, listed below. RH∆hx∆ku80 TIR1 (RH∆ku80∆hxgprt/pTub 5’UTR-OsTir1-3xFlag-DHFR 3’UTR-CAT): The inventors used the CRISPR/Cas9 system for genome editing, comined with the AID degradation system to generate th…
DNA Plasmids for the Modulation of Gene ExpressionLee, Young Je (Ryan) ; Moon, Tae Seok
T-019002
— These set of plasmids allow for the repression and de-repression of fluorescent proteins (GFP and mCherry) through CRISPR interference and antisense RNA. Publication: Programmable control of bacterial gene expression with the combined CRISPR and antisense RNA system
Irf8 Delta32 MiceMurphy, Kenneth
T-019003
— Irf8 Delta32 mice have a CRISPR targetted deletion in the enhancer of the mouse Irf8 gene located at +32 kilobases from the Irf8 gene promoter. This deletion removes the binding site for the Jun/Batf3/Irf8 complex and results in a complete and permanent elimination of the development of the cDC1 lin…
SAMD9L-knockout miceBoon, Adrianus "Jacco"
T-019004
— CRISPR-Cas9 gene editing was used to modify the coding region of the SAMD9L mouse gene. The genetic modification resulted in the deletion of the full length production of the protein. This modification was made in a C57BL/6 genetic background.
Human Monoclonal Antibodies for Influenza VirusEllebedy, Ali
T-019018
— These are recombinant human monoclonal antibodies that are directed against two conserved internal proteins of the influenza virus.
pRRLsinPGK-GFPppt and FCIV plasmidsLi, Mingjie
T-019021
— pRRLsinPGK-GFPppt : Plasmid DNA directing expression of green fluorescent protein in a lentiviral shuttle vector under the control of the phosphoglycerate kinase (PGK) promoter. FCIV: Plasmid DNA directing expression of Venus (a fluorescent protein) in a lentiviral shuttle vector under the control o…
NMI knockout miceBoon, Adrianus "Jacco"
T-019025
— CRISPR-Cas9 gene editing was used to modify the coding region of the NMI mouse gene. The genetic modification resulted in the deletion of the full length production of the protein. This modification was made the C57BL/6J genetic background. NMI is a host protein involved in innate immune signaling a…
MAP3K6-knockout mouseBoon, Adrianus "Jacco"
T-019026
— CRISPR-Cas9 gene editing was used to modify the coding region of the MAP3K6 mouse gene. The genetic modification resulted in the deletion of the full length production of the protein. This modification was made in a C57BL/6J genetic background. MAP3K6 is a signaling molecule and could be the target …
Plasmid (pHW2000): Development of a reverse genetics system for Bourbon virusBoon, Adrianus "Jacco"
T-019027
— A plasmid based reverse genetics system for Bourbon virus was created. This system and related plasmids allow for the creation of infectious Bourbon virus and evaluate the impact of genetic variation on the virus (replication, disease, antibody-mediated neutralization etc.). It also allows for the c…
Antibodies to MDKKapoor, Vaishali ; Hallahan, Dennis
T-018978
— MDK is a molecular target for treatment of cancer. These antibodies are to the functional domain of MDK.