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New Approach for the Treatment of Brain CancersLi, Yuping ; Diamond, Michael ; Curiel, David ; Chheda, Milan
T-021004
— Published Date: 12/20/2024 Value Proposition: Treats brain tumors by combining a hematopoietic growth protein and cancer therapeutics to increase survival rates. Technology Description Researchers at Washington University in St. Louis have developed a new way to treat brain cancers by combining…
Protein Used to Enhance T cell Expansion to Improve Cancer ImmunotherapyChou, Chun ; Egawa, Takeshi
T-016284
— Published Date: 12/19/2024 Value Proposition: This invention utilizes a protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapy. Technology Description Researchers at Washinton University in St. Louis have developed a mutant AP4 protein that is desig…
New Process to Diagnose Several Classes of Tauopathies in the BrainHorie, Kanta ; Mukherjee, Soumya ; He, Yingxin "Chloe" ; Bateman, Randall ; Barthelemy, Nicolas
T-020932
— Published Date: 12/19/2024 Value proposition: Novel method used to detect tau proteins in the brain using biofluids. Technology Description Researchers at Washington University in St. Louis have developed a method to identify and differentiate primary and secondary tauopathies in the brain. Man…
Procedure to Improve the Performance of On-table Adaptive RadiotherapySchmidt, Matthew ; Kim, Taeho
T-019735
— Published Date: 12/19/2024 Value Proposition: First clinical application of super resolution (SR) MRI reconstruction for 2D cine MRI in real-time radiotherapy. Technology Description Researchers at Washington University in St. Louis have developed a novel application for super-resolution (SR) c…
Super Resolution cine MRI for Improving Image Quality and Tumor Targeting During RadiotherapyKim, Taeho
T-019747
— Published Date: 12/18/2024 Value Proposition: First clinical application of super resolution (SR) MRI reconstruction for 2D cine MRI in real-time radiotherapy. Technology Description Researchers at Washington University in St. Louis have developed a novel application for super-resolution (SR) c…
Mechanically Optimized Synthetic Dendritic Cells for the Expansion of Antigen-Specific T CellsSarker, Bapi ; Klechevsky, Eynav ; Pathak, Amit
T-017391
— Published Date: 12/19/2024 Value Proposition: New method for expanding T cells against individualized tumor-specific mutational antigens. Technology Description Researchers at Washington University in St. Louis have developed a device that enables high-throughput production of patient specific …
New Method for Predicting a Patient’s Response to Drug Therapy for Treatment of Irregular Heart RhythmsZhu, Wandi ; Naegle, Kristen ; Silva, Jonathan
T-018631
— Value Proposition: New process that uses ion channel voltage sensing parameters to predict antiarrhythmic drug response. Technology Description Researchers at Washington University in St. Louis have developed a new process for predicting patients’ response to mexiletine drug therapy. Mexil…
New Process for Treating Multiple MyelomaSilva-Fisher, Jessica
T-020751
— Value Proposition: Long non-coding RNA as biomarker and therapeutic target for treating diagnosed multiple myeloma patients. Technology Description Researchers at Washington University in St. Louis have developed a long non-coding RNA as a diagnostic marker and clinical target for multiple my…
Transmembrane Protein Targeted to Treat Obesity and Associated Metabolic DiseasesJia, Wentong ; Diamond, Michael ; Brestoff Parker, Jonathan
T-020807
— Value Proposition: This invention targets MXRA8 protein as a therapy for obesity and other metabolic diseases. Technology Description Researchers at Washington University in St. Louis have developed an MXRA8 targeted therapeutic to treat obesity and associated metabolic diseases. MXRA8 is the re…
Small Molecule Gastrin-releasing peptide receptor (GRPR) antagonists used for Anti-Itch TreatmentDolle, Roland "Ron" ; Zhou, Mingzhou
T-020002
— Value Proposition: Small molecule Gastrin-releasing peptide receptor (GRPR) antagonists used to treat chronic itch. Technology Description Researchers at Washington University in St. Louis have discovered a group of small molecule Gastrin-releasing peptide receptor (GRPR) antagonists to treat c…
Intraoperative Mapping Tool for Identifying Functional Brain Areas in Anesthetized PatientsBreshears, Jonathan ; Leuthardt, Eric
T-010379
— Value Proposition: New technique for examining active brain areas in unconscious neurosurgical patients. Technology Description Researchers at Washington University in St. Louis have developed a new process that includes a new use for existing electrocorticographic (ECoG) grids, an amplifier, an…
Method To Remove Brain Stimulation Artifacts in Neural SignalsXie, Tao ; Willie, Jon ; Leuthardt, Eric ; Brunner, Peter
T-020083
— Value proposition: Method and system for removing multiple types of brain stimulation artifacts in neural signals to improve neurological diagnoses and therapies. Technology Description Researchers at Washington University in St. Louis have developed a method to remove brain stimulation artifact…
Method to Perform Spectral Biopsy of Electrophysiological Brain Function for use in Monitoring and Diagnosing Neurological ConditionsLeuthardt, Eric ; Brunner, Peter
T-019651
— Value Proposition: New process used to detect/measure the intrinsic neuronal brain activity to diagnose neurological and psychiatric diseases. Technology Description Researchers at Washington University in St. Louis have developed a method called Tau-Modulation to assess intrinsic neuronal activi…
Real-time 3D MRI for use in Diagnostic MRI and MRI-guided RadiotherapyPark, Chunjoo (Justin) ; Kim, Taeho
T-019011
— Value Proposition: Method combines two previously known techniques to enable real time 3D MRI image reconstruction for improving patient care. Technology Description Researchers at Washington University in St. Louis have developed a method for real-time, high-resolution 3D MRI that can be used i…
Engineered Polymer-Peptide for Treatment of Lower Back Pain Caused by Chronic Back PainSpeer, Julie ; Barcellona, Marcos ; Setton, Lori
T-019297
— Value Proposition: Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating back pain. Technology Description Researchers at Washington University in St. Louis have developed an engineered peptide-functionalized polymer that can support healthy nucle…
Iris-Sealing Mask for the Mitigation of the Spread of Patient Aerosols Undergoing Intubation, Extubation, and Respiratory SupportCashin, John ; Zayed, Mohamed
T-020364
— Value Proposition: Masking device designed to provide protection for healthcare professionals from the spread of respiratory droplets during the extubation, intubation, and ongoing respiratory support of patients. Technology Description Researchers at Washington University in St. Louis have dev…
Sutureless Device for Connecting Vessels End-to-SideCashin, John ; Zayed, Mohamed
T-020365
— Value Proposition: Simple device that allows for sutureless end-to-side surgical anastomosis of vessels. Technology Description Researchers at Washington University in St. Louis have developed a device which facilitates the sutureless end-to-side anastomosis of vessels. The TAPV device may be …
Method that Uses Taurine as a Storage Supplement for Platelet ConcentratesSpinella, Philip ; Shea, Susan ; Thomas, Kimberly
T-019841
— Value Proposition: Composition of matter that uses taurine to improve cold platelet storage shelf life and functionality. Technology Description Researchers at Washington University in St. Louis have developed a method to cold store platelets using taurine supplementation. There is a crucial ne…
Novel Software to Increase the Accuracy of Proton TherapyO'Sullivan, Joseph ; Zhao, Tianyu ; Medrano, Maria ; Chen, Xinyuan ; Williamson, Jeffrey
T-020198
— Technology Description Developed by researchers in the Williamson and O’Sullivan Labs at the Washington University in St. Louis, this technology is a novel software platform that creates more accurate proton beam targeting to tumors. The software is used during proton therapy treatment plann…
Treatment of COVID-19 Using Fluvoxamine MaleateLenze, Eric ; Reiersen, Angela
T-019712
— Value Proposition: Novel method for treating short- and long-term symptoms of COVID-19 using a selective serotonin reuptake inhibitor (SSRI) and a sigma-1 receptor (S1R) agonist. Technology Description Researchers at Washington University in St. Louis have developed a novel method for treating …
