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Absolute Perfusion Reserve (T-020127)Bugenhagen, Scott
T-020127
— Ask Experimental de-risking strategy Regulatory advice Background: Fractional flow reserve (FFR) is the current gold standard for grading coronary artery stenoses; however, more recent studies have demonstrated no significant improvement in primary patient outcomes when using FFR…
Deep Tissue Diagnostics with Disposable Fiber-Optic DeviceYang, Shuo ; Ling, Jingwei ; Hu, Song
T-020656
— T-020656 – Deep Tissue Diagnostics with Disposable Fiber-Optic Device Technology Description Researchers from the laboratory of Song Hu has developed a miniaturized fiber-optic device capable of minimally invasive measurements of deep-tissue biomechanical properties. The device can be rea…
Lrp1 and the Blood Brain BarrierVirgin, Herbert ; Leung, Daisy ; Ganaie, Safder ; Amarasinghe, Gaya
T-019577
— T-019577 – Lrp1 and the blood brain barrier Technology Description Researchers in Gaya Amarasinghe’s laboratory at Washington University have engineered new protein fragments (RVFV Gn) to target LRP1, which was recently identified as an essential entry factor for Rift Valley Fever Virus (RVF…
Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem CellsLuff, Stephanie ; Sturgeon, Christopher
T-018886
— T-018886 — Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem Cells Technology Description In vitro generation of CD34+ hematopoietic progenitor cells (HPC) that faithfully recapitulate in vivo behavior is an area of ongoing research. A key characteristic of CD34+ …
Radiotracers to detect early Parkinson’s diseaseQiu, Lin ; Yu, Yanbo ; Kotzbauer, Paul ; Tu, Zhude "Will"
T-020559
— Radiotracers to detect early Parkinson’s disease Technology Description Researchers at Washington University in St. Louis, led by Dr. Zhude Tu, have developed two imaging agents for α-synuclein (α-syn) aggregation for use to diagnose early Parkinson’s disease, track dise…
Engineered Oncolytic Zika Virus Therapy for GlioblastomaGorman, Matthew ; Chheda, Milan ; Diamond, Michael
T-017429
— T-017429 Engineered Oncolytic Zika Virus Therapy for Glioblastoma Technology Description Researchers in the laboratories of Michael Diamond and Milan Chheda at Washington University have developed prospective treatments for glioblastoma (GBM) through the application of an engineered Zika virus (ZI…
Myocardial perfusion SPECT optimizationSiegel, Barry ; Yu, Zitong ; Rahman, Md Ashequr ; Jha, Abhinav Kumar
T-020357
— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…
Small Molecule Agonists of EphA Receptors to Ameliorate DiabetesDolle, Roland "Ron" ; Asadi Jomnani, Farzad ; Piston, David
T-020153
— T-020153 – Small Molecule Agonists of EphA Receptors to Ameliorate Diabetes Technology Description Blood glucose levels (left), post-treatment plasma glucagon (center) in WCDD301 treated NOD (non-obese diabetic) mice with moderate hyperglycemia. Blood glucose levels (right) in Streptozotocin-ind…
Systems and Methods for Detection and Quantification of Axial SpondyloarthritisYokoyama, Wayne ; Paley, Michael
T-020486
— T-020486 – Systems and Methods for Detection and Quantification of Axial Spondyloarthritis Technology Description Researchers at Washington University in St. Louis, led by Dr. Michael Paley, have developed an assay to diagnose axial spondyloarthritis (axSpA) in HLA-B*27-positive patients.…
Robust Suite of Technologies Offers Significant Enhancements for Whispering Gallery Mode (WGM) Microresonator Sensors and Laser SystemsOzdemir, Sahin ; Yang, Lan ; He, Lina ; Chen, Da-Ren ; Zhu, Jiangang
T-009642
— WGM microresonators are an immature technology with room for improvement Microresonators are optical devices that are an important component of microlasers used in optoelectronics, data communications, and sensing. Most microresonators are WGM type, which confine light to a very small volume for si…
Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor ResponseVerma, Priyanka ; Zhao, Peinan ; Lomonosova, Elena ; Mullen, Mary
T-020659
— T-020659 — Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor Response Technology Description Most patients diagnosed with high-grade serous ovarian cancer (HGSOC) undergo first-line platinum therapy and PARP inhibitor maintenance therapy. However, the degree to which HGSOC p…
Zbtb46, a novel target for cancer therapyKrchma, Karen ; Kabir, Ashraf Ul ; Choi, Kyunghee
T-020458
— T-020458 — Zbtb46, a novel target for cancer therapy Technology Description Solid neoplasms are difficult to treat using immune checkpoint inhibitors in part because of the immunosuppressive nature of the tumor microenvironment. Researchers at Washington University School of Medicine, led b…
Development of CD163 targeting agent for imaging and therapyZhang, Xiuli ; Heo, Gyu Seong ; Liu, Yongjian
T-020196
— T-020196 CD163 Targeting Agent for Imaging and Therapy Technology Description Researchers in Yongjian Liu’s laboratory at Washington University have synthesized a new peptide-based CD163 radiotracer. CD163 is a well-known biomarker specific to macrophages implicated in multiple diseases, but…
Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammationSivapackiam, Jothilingam ; Sharma, Vijay
T-019479
— T-019479 Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammation. Technology Description 18F-fluorodeoxyglucose (18F-FDG) has long been used for the diagnosis of neoplasms, and recently Alzheimer’s disease. However, 18F-FDG signals are often not correlated with…
PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen SpeciesSivapackiam, Jothilingam ; Satham, Lakshminarayana ; Sharma, Vijay
T-020300
— T-020300 PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen Species Technology Description Reactive Oxygen Species (ROS) is known to contribute to the pathogenesis of neuropathological conditions such as Alzheimer’s disease and cancer. However, there …
Multi-energy window approaches for quantitative SPECTThorek, Daniel ; Li, Zekun ; Jha, Abhinav Kumar
T-019824
— T-019824 Multi-energy window approaches for quantitative SPECT Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised a method to reliably obtain and significantly improve quantification of alpha-particle based SPECT tracer uptake, particularly …
A long non-coding RNA in early and late-stage breast cancer as a prognostic marker, diagnostic marker, and therapeutic target.Maher, Christopher ; Eteleeb, Abdallah ; Silva-Fisher, Jessica
T-020366
— Technology Description Researchers in Dr. Jessica Silva-Fisher’s laboratory have developed antisense oligonucleotide targeting a long non-coding RNA (lncRNA), LINC00355, as a treatment for late-stage relapse (LSR) breast cancer. LINC00355 is highly expressed in LSR breast cancer patients and…
Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased ProfitabilityWu, Yu ; Mahon, Rebecca "Nicky" ; Raman, Caleb ; Reynoso, Francisco ; Sun, Baozhou ; Knutson, Nels ; Hao, Yao ; Schmidt, Matthew
T-019746
— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…
Uropathogen VaccinesPinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan ; Ellebedy, Ali ; Feldman, Mario ; Dodson, Karen ; Hultgren, Scott
T-020120
— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…
Super-Resolution Dental Tetrahedron Beam Computed Tomography (TBCT) System Improves Image Quality Without Sacrificing Speed for Expanded Clinical ApplicationsZhou, Shuang ; Tan, Yuewen ; Chen, Qinghao ; Zhang, Tiezhi
T-019620
— Current cone beam computed tomography (CBCT) systems lack concurrent high-resolution imaging and speed With current digital CBCT imaging technology, x-ray tube power limitations mean high-resolution images can only be achieved by reducing imaging speeds. In dental applications, CBCT suffers from im…