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Grpr Flox Mouse StrainChen, Zhou-Feng
T-019158
— Grpr floxed mouse strain This mouse strain has loxP sites flanking exon 2 of the Grpr gene. Inventors backcrossed the mice into the C57Bl/6J background. The mouse strain was used to study contagious itch and demonstrated that GRP-GRPR signaling is necessary and sufficient for transmitting contagiou…
Grp Floxed mouse strainChen, Zhou-Feng
T-019157
— Grp floxed mouse strain These mice have loxP sites flanking exon 1 of the Grp gene. It was used to study the mechanism of itch and further interrogation of itch-nerve fibers in the skin under chronic pruritus. Publication: Exploration of Sensory and Spinal Neurons Expressing GRP in Itch and Pain …
Xcr1 IRES mCherry-hCre Mouse StrainMurphy, Theresa ; Durai, Vivek ; Murphy, Kenneth
T-019142
— Xcr1 IRES mCherry-hCre Mouse Strain This genetically modified mouse strain expresses the fluorescent marker mCherry and a human codon optimzed Cre in the same transcript as the chemokine receptor XCR1. XCR1 is specifically expressed in cDC1s, allowing specific deletion of genes in and the fluoresce…
Development of a Preclinical NF1-MPNST Platform Suitable for Precision Oncology Drug Discovery and EvaluationLi, Shunqiang ; Hirbe, Angela
T-019044
— This technology contains a set of patient derived xenograft cell lines. These cell lines represent the heterogeneity of human malignant peripheral nerve sheath tumors (MPNSTs) that can be used to test novel agents to move forward into clinical trials.
STING N153S knock-in miceMiner, Jonathan
T-019131
— STING N153S knock-in mice These mice carry a N153S (asparagine to serine) substitution in the Tmem173 (transmembrane protein 173 or STING) gene. The mice were created using CRISPR/Cas9 with a single guide RNA designed based on specificity and proximity to the targeted STING mutation site. Two indep…
Human HLA Monomers and Murine MHC-1 MonomersSchreiber, Robert
T-019046
— This technology contains a panel of human or mouse specific monomers for staining T cells to enumerate antigen specific cells. The proteins have been produced in E coli after the generation of plasmids encoding each monomer. The proteins are folded in association with unique peptides and purified by…
Antibodies to Western Equine Encephalitis Virus (WEEV)VanBlargan, Laura ; Austin, Stephen ; Diamond, Michael
T-019128
— Antibodies against Western Equine Encephalitis Virus (WEEV) Inventors demonstrated the antibodies reactivity with WEEV-infected cells or with WEEV proteins. These antibodies can be used for diagnostic and potentially therapeutic purposes.
Bhlhe40 flox/flox miceEdelson, Brian
T-019054
— The Bhlhe40 flox/flox mice on the C57BL/6 background originated as a KO-first promoter-driven mouse line from the Knockout Mouse Project and were purchased from the Jackson Laboratory. These initial mice contained a Bhlhe40 allele with a splice acceptor-LacZ reporter and a Neo cassette flanked by tw…
CHO Gadd7 knockdown clones and controlBrookheart, Rita ; Schaffer, Jean
T-019114
— CHO Gadd7 knockdown cell lines Inventors generated two stable Chinese Hamster Ovary (CHO) cell lines with knockdown of gadd7 by transfecting cells with a custom siRNA plasmid targeting hamster gadd7 (KD1 and KD2) and a control CHO cell line by transfecting cells with a custom scrambled siRNA plasmi…
Plasmids for luciferase expression in CryptosporidiumFunkhouser-Jones, Lisa ; Sibley, Laurence
T-019121
— Plasmids for luciferase expression in Cryptosporidium The plasmids listed below are for targeting insertion into the TK and UPRT loci in Cryptosporidium parvum. To generate the plasmids, the inventors modified a previously described nanoluciferase (Nluc) reporter fused to neomycin resistance (NeoR)…
Mice with genetic alteration in STAT3Cooper, Megan
T-019059
— This mouse strain has a genetic alteration in STAT3 and can be used to understand the role of STAT3 in human disease. Publication: Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
pAAV5-CaMKII-mSK2-AqAA-Flag-eYFP packaged into an AAV5 capsidBruchas, Michael ; Moron-Concepcion, Jose
T-019068
— This capsid expresses a dmoninant negative non-functional form of the SK2 channel present in neurons. This allows us to directly measure the effects of SK2 in hippocampal neurons.
Murine Tumor Cell LinesSchreiber, Robert
T-019119
— Murine tumor cell lines Murine syngeneic MCA induced tumor lines have been developed and characterized by the Schreiber Lab and provide critical models to study drugs or pathways that impact tumor growth or rejection. In particular they are used to study mechanism of action of immune checkpoint blo…
Expression plasmid to examine Kelch domain of Keap 1Amarasinghe, Gaya
T-019071
— This expression plasmid can be used to identify inhibitors for Keap1 – a pathway that is invoIved in oxidative stress response and implicated in Marburg virus infection. Publication: Dimerization controls Marburg virus VP24-dependent modulation of host antioxidative stress responses
Gadd7 haploinsufficient mutant CHO cell lineOry, Daniel ; Listenberger, Laura ; Schaffer, Jean
T-019113
— Gadd7 haploinsufficient mutant CHO cell line Inventors generated a mutant Chinese Hamster Ovary (CHO) cell line with disruption of one allele encoding Gadd7, a non-coding RNA. CHO cells were transduced with retrovirus at a low multiplicity of infection and mutants were isolated. Number of retrovira…
Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD155 (PVR)Colonna, Marco
T-005375
— Target: CD155 is a adhesion receptor, orginally known as the cellular receptor for Polio Virus. Notes: Clone name is SK II 4.3Information on antibody against poliovirus receptor (CD155) Herein, we describe the generation of a murine antibody that recognizes poliovirus receptor (CD155). We made this antibody by immunizing mice with SK-N-S1 human neuroblastoma cells. We then validated this antibody using flow cytometry. …
human iPSC cells to model VCPWeihl, Conrad
T-019162
— Valosin Containing Protein (VCP) patient derived fibroblasts, reprogrammed into iPSC cells and corresponding gene corrected line. These cells can be used to model VCP associated muscle disease, ALS, and dementia.
B-122 and Alf-161 – Hamster IgG Monoclonal Antibodies against Mouse/Rat IL-1 Beta and Mouse IL-1 AlphaSchreiber, Robert
T-000125
— Target: Mouse/rat interleukin-1 beta and mouse interleukin-1 alpha. Located on macrophages, dendritic cells, T and B cells. Notes: Clone name is B-122 and Alf-161Information on antibodies against IL-1 beta: The role of murine IL-1 beta in vitro and in vivo has not been defined. We describe here the production of neutralizing and immunoprecipitating mAb and polyclonal antibodies specific for murine IL-1 beta and their application to a characterization of the…
Armenian hamster anti-mouse TCR Vb 8.3 IgG3 monoclonal antibody (clone 1B3.3)Allen, Paul
T-000304
— Target: Full length mouse Vb 8.3 TCR but not 8.1 or 8.2. Vb 8.3. Application: Flow cytometryThis antibody was made by immunizing Armenian hamsters. It was used to study the mechanisms that act to keep only one functional TCR beta-chain per cell and the effect of selecting ligand density on positive selection and endogenous receptor usage in mice. Publication: TCR transgenic mice in which …
Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD96 (Tactile)Colonna, Marco
T-005374
— Target: CD96 is a T cell-specific receptor indicative of T cell activation. Notes: Clone name NK92.39.1. For use in flow cytometry.Researchers generated the antibodies by immunizing mice with NK92 cells and selected hybridomas that plocked binding of PVR to NK92. These antibodies have been used to study natural killer cell target cell adhesion. Publication: Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by …
