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Achondroplasia (ACH) Mouse ModelOrnitz, David
T-000483
— Target: Mouse model with the mutation for ACH knocked in.Description: Inventors created a transgenic mouse model of achondroplasia by targeting the expression of activated FGFR3 to growth plate cartilage in mice using regulatory elements from the collagen II gene. As with humans carrying the achondroplasia mutation, the resulting transgenic mice were dwa…
Crry-deficient mouse strainAtkinson, John ; Molina-Vicenty, Hector
T-003105
— Crry-knockout mouse strain (Crry -/-)Researchers generated mice deficient in Crry by disrupting exon 5 of the mouse Crry gene. The mice are sensitive to complement deposition and activation, especially the C3 component of complement on the surface of the placenta. Publication: A Critical Role for Murine Complement Regulator Crry in Fe…
Piggybac vectors for gene delivery and fluorescent reporter assaysMadison, Blair
T-019191
— Plasmid vectors for shRNA expression, CRISPR reagent delivery, protein expression, reporter (promoter or 3’UTR) assays, and non-coding RNA delivery Efficient gene delivery is problematic, especially in hard to transfect primary cells (e.g. organoids). Commercial piggybac vectors are sparse and …
Ifnl2/Ifnl3 double knock-out mouseBaldridge, Megan
T-019187
— Ifnl2/Ifnl3 double knock-out mouse strain This mouse strain is in the C57BL/6 background with Ifnl2, Ifnl3 genes disrupted to create a double knock-out. It was generated with assistance from the Washington University GEIC. This strain was used to study the regulation of the innate immune response t…
Low cost electrode decoupled redox flow batteries for grid-scale energy storageRamani, Vijay ; Sankarasubramanian, Shrihari
T-018530
— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed an electrode decoupled redox flow battery (RFB) with stable electrolyte materials that can generate power densities comparable to all-Vanadium RFBs at less than half the cost. RFBs are a promising option for …
Murine Hybridoma producing Monoclonal Antibodies against Human NKp44Colonna, Marco
T-004356
— Target: NKp44 is a novel triggering surface molecular specifcially expressed by activated natural killer cells. Notes: Clone name 448.189 Marco Colonna, MDInventors generated NKp44 monocolonal antibodies by immunizing mice with a NKp44-human crystallizable fragment (Fc) fusion protein. The antibodies have been used to study innate and adaptive immune responses. Publication: Paradoxic inhibition of human natural interferon-producing cells by the activ…
IL-1 beta deficient miceFerguson, Thomas ; Chaplin, David
T-001876
— Mouse strain deficient in IL-1 betaInventors created the IL-1 beta deficient mouse strain by targeting the IL-1 beta gene in embryonic stem cells. These mice develop and grow normally. Endotoxin-stimulated peritoneal macrophages from IL-1beta- deficient mice showed normal synthesis and cellular release of IL- 1alpha after treatment w…
High-speed, low-cost, short-haul optical communications with on-chip polarization division multiplexingIvanovich, Darko ; Gruev, Viktor ; Chamberlain, Roger
T-018955
— Technology Description Engineers in Prof. Roger Chamberlain’s laboratory have developed a low-cost multiplexing technology for high-speed optical communications in data centers and other short-haul applications. This visible light communication (VLC) system is designed to create distinct par…
Steerable Thermoablation Probe for Improved Access to Brain LesionsLeuthardt, Eric
T-015768
— Technology Description An interdisciplinary team led by Professor Eric Leuthardt has developed a steerable device that can be integrated into existing thermoablation systems to treat abnormal brain lesions. Thermoablation is a more targeted and less disruptive method for treating lesions than chem…
Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive functionLuo, Zonghua ; Liu, Hui ; Jin, Hongjun ; Tu, Zhude "Will"
T-016517
— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…
Grueneisen-memory photoacoustic microscopyZhang, Chi ; Wang, Lidai ; Wang, Lihong
T-014165
— Lihong Wang, Professor at Washington University in St. Louis, is a pioneer in the field of Photoacoustic (PA) Imaging. His innovations have enabled non-invasive imaging of living organisms at scales ranging from subcellular to whole-body at depths and resolutions that are simply impossible with any …
Immunohistochemical diagnosis of human renal chromophobe carcinomaGaut, Joseph ; Crimmins, Dan ; Ladenson, Jack
T-011164
— This novel immunohistochemical marker would be a valuable diagnostic aid to the practicing surgical pathologist who is confronted with this particular diagnostic challenge. Companies may license this antibody for clinical testing, or cases may be referred to Washington University for subspecialty c…
Polyclonal antibody for straining human Cytokeratin 13 (HuCK13)Ladenson, Jack
T-004395
— Rabbit polyclonal antibodies were generated using two distinct 20-mer synthetic peptides corresponding to the unique C-terminal extension of HuCKI 3 using standard protocols. Final purification used the corresponding peptide immunogen affinity column. Possible uses: histological detection in tumors …
Measurement of NT-ProBNP in human blood using a monoclonal antibodyLaterza, Omar ; Landt, Yvonne ; Ladenson, Jack
T-004030
— This is a monoclonal antibody specific for NT-Pro BNP and can be used singly in a competitive immunoassay to measure the amount of this analyte in blood samples for the purpose of diagnosis or monitoring of congestive heart failure. In addition, it could be used in a sandwich immunoassay with a mono…
Normothermic Extracorporal Liver Perfusion (NELP)Lin, Yiing ; Banan, Babak ; Chapman Sr., William
T-015492
— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…
Reversibly switchable photoacoustic tomography using a bacterial phytochrome as a genetically encoded near-infrared photochromic probeYao, Junjie ; Li, Lei ; Wang, Lihong
T-015670
— The invention is a novel photoacoustic imaging technique, termed reversibly switchable photoacoustic tomography (RS-PAT). It exhibits a large penetration depth, a high detection sensitivity, and a spatial super-resolution. The most important feature of this technique is that it significantly incre…
Patient Access Scheduling SystemWhipple, Toni ; Hughes, Scott ; Melnek, Christine ; Reynolds, Steven ; Dodt, Jeremy ; Mantia, Jill
T-015846
— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…
Zuum – appCorcoran, Heather ; Colditz, Graham
T-011983
— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.
Quit HelpersSumner, Walton ; Colditz, Graham ; McQueen, Amy
T-014916
— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…
Pediatric Hematology-Oncology Roadmap BuilderLackey, Ian ; Drozda, Mandy ; Jones, Sally ; Brown, Robert ; Rich, Eliot
T-010823
— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …
