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Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive functionLuo, Zonghua ; Liu, Hui ; Jin, Hongjun ; Tu, Zhude "Will"
T-016517
— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…
Grueneisen-memory photoacoustic microscopyZhang, Chi ; Wang, Lidai ; Wang, Lihong
T-014165
— Lihong Wang, Professor at Washington University in St. Louis, is a pioneer in the field of Photoacoustic (PA) Imaging. His innovations have enabled non-invasive imaging of living organisms at scales ranging from subcellular to whole-body at depths and resolutions that are simply impossible with any …
Immunohistochemical diagnosis of human renal chromophobe carcinomaGaut, Joseph ; Crimmins, Dan ; Ladenson, Jack
T-011164
— This novel immunohistochemical marker would be a valuable diagnostic aid to the practicing surgical pathologist who is confronted with this particular diagnostic challenge. Companies may license this antibody for clinical testing, or cases may be referred to Washington University for subspecialty c…
Polyclonal antibody for straining human Cytokeratin 13 (HuCK13)Ladenson, Jack
T-004395
— Rabbit polyclonal antibodies were generated using two distinct 20-mer synthetic peptides corresponding to the unique C-terminal extension of HuCKI 3 using standard protocols. Final purification used the corresponding peptide immunogen affinity column. Possible uses: histological detection in tumors …
Measurement of NT-ProBNP in human blood using a monoclonal antibodyLaterza, Omar ; Landt, Yvonne ; Ladenson, Jack
T-004030
— This is a monoclonal antibody specific for NT-Pro BNP and can be used singly in a competitive immunoassay to measure the amount of this analyte in blood samples for the purpose of diagnosis or monitoring of congestive heart failure. In addition, it could be used in a sandwich immunoassay with a mono…
Normothermic Extracorporal Liver Perfusion (NELP)Lin, Yiing ; Banan, Babak ; Chapman Sr., William
T-015492
— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…
Reversibly switchable photoacoustic tomography using a bacterial phytochrome as a genetically encoded near-infrared photochromic probeYao, Junjie ; Li, Lei ; Wang, Lihong
T-015670
— The invention is a novel photoacoustic imaging technique, termed reversibly switchable photoacoustic tomography (RS-PAT). It exhibits a large penetration depth, a high detection sensitivity, and a spatial super-resolution. The most important feature of this technique is that it significantly incre…
Patient Access Scheduling SystemMelnek, Christine ; Reynolds, Steven ; Whipple, Toni ; Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill
T-015846
— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…
Zuum – appCorcoran, Heather ; Colditz, Graham
T-011983
— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.
Quit HelpersSumner, Walton ; Colditz, Graham ; McQueen, Amy
T-014916
— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…
Pediatric Hematology-Oncology Roadmap BuilderLackey, Ian ; Drozda, Mandy ; Jones, Sally ; Brown, Robert ; Rich, Eliot
T-010823
— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …
VISIT-TS Version 2Striley, Catherine ; Vachon, Matthew ; Schroeder, Miriam ; Gordon, Mollie ; Black, Kevin
T-016526
— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…
Agonistic Anti-CD40 Monoclonal AntibodiesKlechevsky, Eynav
T-015344
— The monoclonal antibodies developed are agaonistic monoclonal antibodies. These antibodies can help in enhancing the immune system by activating dendritic cell subsets. Furthermore, these antibodies are unique, as they can activate Dendritic cells without the need for cross-linking the receptor.
Neonatal Eating Outcome (NEO) AssessmentPineda, Roberta
T-014917
— To order a NEO Assessment, Click Here. If the link does not work, copy and paste https://commerce.cashnet.com/NEO into your search bar. Summary: Eating is an important part of daily life; it ensures nutrition for growth and is an important activity of daily living with strong social implications. …
Therapeutic Approach for Huntington’s Disease (HD)Kim, Albert ; Yano, Hiroko
T-016079
— Dr. Hiroko Yano and Dr. Albert Kim, and their research teams at the Washington University School of Medicine in St. Louis developed and extensively evaluated a novel therapeutic approach using DNMT inhibitors to treat Huntington’s Disease (HD) and other neurodegenerative disorders. Currently D…
Treating Tuberculosis with Host-Directed Drug TargetingChandra, Pallavi ; Philips, Jennifer
T-017060
— Background: Worldwide, there are over 10 million new cases of tuberculosis (TB) annually, resulting in 1.8 million deaths. This makes Mycobacterium tuberculosis (Mtb), the bacterium causing TB, the world’s leading infectious disease killer. Even for drug susceptible TB, the treatment courses a…
Cytokines-induced-memory-like NK cells with reduced NKG2A checkpoint signalingRomee, Rizwan ; Berrien-Elliott, Melissa ; Fehniger, Todd
T-017001
— Background: Natural Killer (NK) and T cells are the primary immune cells being explored for cancer immuntherapy. NK cells are relatively short-lived, making the therapy less susceptible to some of the side effects currently associated with using T cells for immunotherapy. Unlike T cells, NK cells ar…
Antiviral therapy targeting viruses within parasitic protozoansKuhlmann, Frederick ; Beverley, Stephen
T-016969
— Background: Parasitic infections remain global health threats and often lead to high death rates in endemic countries. Found in 98 countries, the Leishmania parasite is particularly dangerous and accounts for an estimated 2 million cases and 50,000 deaths per year across the world. However, Leishman…
Drugs to supplement microglial metabolism during treatment of Alzheimer’s diseaseUlland, Tyler ; Colonna, Marco
T-017401
— Background: Alzheimer’s disease (AD) is the 6th leading cause of death in the United States, and yet causation of the disease is poorly understood and targets for therapeutic intervention are still being identified. Recently, mutations in the immune receptor TREM2 have been found to be strongl…
Lysosomal Enzyme GlcNAc-1-phosphotransferase with Enhanced Ability to Phosphorylate Lysosomal EnzymesLiu, Lin ; Lee, Wang ; Doray, Balraj ; Kornfeld, Stuart
T-016569
— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…