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Reproducible High Yielding Cu-64 Radioisotope Manufacturing
Zerkel, Patrick ; Lawrence, Luke ; Gaehle, Gregory
T-018514

— Background: Its unique imaging characteristics and favorable half-life and decay properties make radioisotope copper-64 (Cu-64) most desirable for PET imaging. To meet the increasing demand, an efficient high yielding Cu-64 manufacturing process is essential. To address this unmet need, scientists f…

CellTags: Tracking Individual Cells during Cell Reprogramming
Morris, Samantha
T-018555

— Background Cell populations are quite heterogeneous yet are typically analyzed in bulk, masking unique behavioral features. This is particularly problematic in cell reprogramming, where in a given population of cells, only a small number complete reprogramming. Single-cell technologies address the …

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Petti, Allegra ; Dunn, Gavin ; Chen, Hong ; Leuthardt, Eric
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic Diseases
Klechevsky, Eynav
T-016609

— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…

Tools for the Detection of High-Density Lipoprotein Transport To and From Tissues
Zinselmeyer, Bernd ; Huang, Li-Hao ; Randolph, Gwendalyn
T-015939

— Background High-density lipoproteins (HDLs) have been widely studied and linked to various diseases, especially metabolic diseases. HDL levels in the blood have traditionally been used as a benchmark for risk of cardiovascular disease. However, these blood tests may be misleading – HDL levels…

MicroRNA-induced Direct Conversion of Human Adult Fibroblasts into Neurons
Abernathy, Daniel ; Yoo, Andrew
T-017136

— Background: Studying late-onset neurodegenerative disorders using patient-specific neurons is one of the primary goals of precision medicine. The ability to generate human neurons that mimic the neurons of elderly individuals will provide an instrumental platform to model and study adult-onset neuro…

Comfortable radiotherapy couch to improve precision and accuracy
Mutic, Sasa ; Zhao, Tianyu
T-018538

— Background: High precision and accuracy is critically needed for the use of radiation treatment and diagnostic imaging (magnetic resonance imaging, computerized tomography, X-ray, positron emission tomography); each of these modalities uses the standard flat couch to manipulate the patient during pr…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
Mayer, Allyson ; Zhang, Yiming ; Higgins, Cassandra ; DeBosch, Brian
T-017417

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Cochlear Fluids Simulator
Salt, Alec
T-018692

— Background: Local drug therapy of the inner ear became popular in the 1990s to treat a number of ear disorders. Local therapy allows the drug to bypass entry barriers, reducing systemic toxicities. For novel drugs to be delivered to the inner ear, pharmacokinetic (PK) values such as half-life and ma…

Spinning Spheres for Magnetic Resonance
Albert, Brice ; Barnes, Alexander
T-017912

— Background: A commonly used approach for the analysis of the molecular structure, content, and purity of solid and liquid samples is magic angle spinning nuclear magnetic resonance (MAS NMR). This technique provides greater resolution to better identify and analyze chemical spectra compared to solid…

Anti-PDZ TIP1 Antibody Therapy for Cancer
Yan, Heping ; Kapoor, Vaishali ; Hallahan, Dennis
T-017064

— Background: Lung cancer is one of the leading causes of cancer-related deaths worldwide. In the United States, it is second most common cancer for men and women and the leader for cancer-related death. Non-small-cell lung cancer (NSCLC) accounts for 85% of all reported lung cancer cases and is relat…

ID CUBE: Interactive Discovery Cube
Kim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong ; Garnett, Roman ; Huang, Yunshen ; Du, Tommy ; Berezin, Mikhail
T-016317

— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…

Insert device that enhances MR and PET image resolution for MR-PET machines
Tai, Yuan-Chuan
T-007555

— Background PET-CT scanners have been widely used in the identification of tumors and localization for biopsies due to its superior ability to detect biochemical and physiological functions. However, one of the main limitations of PET-CT is the inability to visualize soft tissues, which may be impor…

Targeting B Cells for Antibody-Mediated Graft Rejection
Nelson, Christopher ; Wang, Xiaoli ; Fremont, Daved ; Edelson, Brian ; Liu, Chang
T-018682

— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …

Washington University Profile System (WUPS)
Komeshak, Rachel ; Lackey, Ian ; Kenney, Kenneth ; Hunstad, David ; Rich, Eliot
T-017287

— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…

Tumor treatment for patients with neurofibromatosis type 1 (NF1)
Gutmann, David ; Weber, Jason
T-007548

— Technology Description Scientists at the Washington University Neurofibromatosis Center have developed a patented, first-in-class method for treating neurofibromatosis type 1 (NF1) with small molecule inhibitors of targets in the mTOR (mammalian target of rapamycin) signaling pathway. NF1 is a rel…

Treatment for Age-Related Macular Degeneration (AMD) by Targeting Cholesterol Transport in Macrophages
Apte, Rajendra
T-011268

— Technology Description Researchers in Prof. Rajendra Apte’s laboratory developed novel methods for treating macular degeneration and other eye diseases by targeting a cholesterol transport pathway involved in the formation of new blood vessels. Age-related macular degeneration (AMD) is a lea…

MRI-based multiparametric cardiac strain analysis of myocardial viability
Cupps, Brian ; Pasque, Michael
T-006692

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Biodegradable beads for capturing phosphorus from water and releasing it as fertilizer
Kim, Doyoon ; Jun, Young-Shin
T-017987

— Engineers in Prof. Young-Shin Jun’s laboratory at Washington University in St. Louis have developed a scalable, effective, environmentally-friendly system for removing phosphorus from water using biodegradable alginate beads that can then be recycled as a slow release fertilizer in soil. This …

In vivo PopQC – Simple quality control system to enhance industrial-scale microbial production of chemicals, biofuels and pharmaceuticals
Xiao, Yi ; Zhang, Fuzhong
T-014647

— Researchers in Prof. Fuzhong Zhang’s laboratory have developed a simple, scalable, broadly-applicable system to enhance fermentation efficiency for biosynthetic production of biofuels, pharmaceuticals, materials and other useful chemicals. Currently, biosynthetic pathways have enabled renewabl…