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Spinning Spheres for Magnetic ResonanceAlbert, Brice ; Barnes, Alexander
T-017912
— Background: A commonly used approach for the analysis of the molecular structure, content, and purity of solid and liquid samples is magic angle spinning nuclear magnetic resonance (MAS NMR). This technique provides greater resolution to better identify and analyze chemical spectra compared to solid…
Anti-PDZ TIP1 Antibody Therapy for CancerYan, Heping ; Kapoor, Vaishali ; Hallahan, Dennis
T-017064
— Background: Lung cancer is one of the leading causes of cancer-related deaths worldwide. In the United States, it is second most common cancer for men and women and the leader for cancer-related death. Non-small-cell lung cancer (NSCLC) accounts for 85% of all reported lung cancer cases and is relat…
ID CUBE: Interactive Discovery CubeKim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong ; Garnett, Roman ; Huang, Yunshen ; Du, Tommy ; Berezin, Mikhail
T-016317
— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…
Insert device that enhances MR and PET image resolution for MR-PET machinesTai, Yuan-Chuan
T-007555
— Background PET-CT scanners have been widely used in the identification of tumors and localization for biopsies due to its superior ability to detect biochemical and physiological functions. However, one of the main limitations of PET-CT is the inability to visualize soft tissues, which may be impor…
Targeting B Cells for Antibody-Mediated Graft RejectionNelson, Christopher ; Wang, Xiaoli ; Fremont, Daved ; Edelson, Brian ; Liu, Chang
T-018682
— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …
Washington University Profile System (WUPS)Lackey, Ian ; Kenney, Kenneth ; Komeshak, Rachel ; Hunstad, David ; Rich, Eliot
T-017287
— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…
Tumor treatment for patients with neurofibromatosis type 1 (NF1)Gutmann, David ; Weber, Jason
T-007548
— Technology Description Scientists at the Washington University Neurofibromatosis Center have developed a patented, first-in-class method for treating neurofibromatosis type 1 (NF1) with small molecule inhibitors of targets in the mTOR (mammalian target of rapamycin) signaling pathway. NF1 is a rel…
Treatment for Age-Related Macular Degeneration (AMD) by Targeting Cholesterol Transport in MacrophagesApte, Rajendra
T-011268
— Technology Description Researchers in Prof. Rajendra Apte’s laboratory developed novel methods for treating macular degeneration and other eye diseases by targeting a cholesterol transport pathway involved in the formation of new blood vessels. Age-related macular degeneration (AMD) is a lea…
MRI-based multiparametric cardiac strain analysis of myocardial viabilityCupps, Brian ; Pasque, Michael
T-006692
— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…
Biodegradable beads for capturing phosphorus from water and releasing it as fertilizerKim, Doyoon ; Jun, Young-Shin
T-017987
— Engineers in Prof. Young-Shin Jun’s laboratory at Washington University in St. Louis have developed a scalable, effective, environmentally-friendly system for removing phosphorus from water using biodegradable alginate beads that can then be recycled as a slow release fertilizer in soil. This …
In vivo PopQC – Simple quality control system to enhance industrial-scale microbial production of chemicals, biofuels and pharmaceuticalsXiao, Yi ; Zhang, Fuzhong
T-014647
— Researchers in Prof. Fuzhong Zhang’s laboratory have developed a simple, scalable, broadly-applicable system to enhance fermentation efficiency for biosynthetic production of biofuels, pharmaceuticals, materials and other useful chemicals. Currently, biosynthetic pathways have enabled renewabl…
Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditionsTadepalli, Sirimuvva ; Morrissey, Jeremiah ; Kharasch, Evan ; Singamaneni, Srikanth
T-014923
— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…
Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injuryLaterza, Omar ; Lockwood, Christina ; Modur, Vijay ; Ladenson, Jack ; Crimmins, Dan ; Gaut, Joseph
T-013292
— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…
Protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapyChou, Chun ; Egawa, Takeshi
T-016284
— Technology Description Researchers in Prof. Takeshi Egawa’s laboratory have developed a mutant AP4 protein that is designed to reduce the time and expense of ex vivo T cell expansion for adoptive cellular immunotherapy, including CAR-T cell cancer immunotherapy. AP4 is a transcription factor…
NMDA receptor modulator for neuroprotection after a strokeTaylor, Amanda ; Zorumski, Charles ; Sun, Min-Yu ; Mennerick, Steven
T-016328
— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…
Accurate, efficient 2D strain mapping with robust detection of strain localizationPless, Robert ; Thomopoulos, Stavros ; Genin, Guy ; Boyle, John
T-014090
— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…
Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer ImmunotherapyCuriel, David
T-011681
— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…
Applicator device for reducing artifacts in MR-guided gynecological brachytherapyGrigsby, Perry ; Zoberi, Jacqueline
T-011297
— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…
Therapy to treat and prevent respiratory disease in pre-term and at-risk neonatesTodd, Elizabeth (Betsy) ; Morley, Sharon "Celeste"
T-017434
— Technology Description Researchers in Prof. S. Celeste Morley’s laboratory have developed a long-lasting prophylactic therapy that could protect pre-term and at-risk infants from pneumonia, respiratory distress and bronchopulmonary dysplasia. Neonates born prematurely are at increased risk f…
High-performance, nanoengineered two-phase cooling system for high powered electronicsShan, Li ; Ma, Binjian ; Agonafer, Damena
T-018032
— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …