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Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditionsTadepalli, Sirimuvva ; Morrissey, Jeremiah ; Kharasch, Evan ; Singamaneni, Srikanth
T-014923
— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…
Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injuryLockwood, Christina ; Modur, Vijay ; Ladenson, Jack ; Laterza, Omar ; Crimmins, Dan ; Gaut, Joseph
T-013292
— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…
Protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapyChou, Chun ; Egawa, Takeshi
T-016284
— Technology Description Researchers in Prof. Takeshi Egawa’s laboratory have developed a mutant AP4 protein that is designed to reduce the time and expense of ex vivo T cell expansion for adoptive cellular immunotherapy, including CAR-T cell cancer immunotherapy. AP4 is a transcription factor…
NMDA receptor modulator for neuroprotection after a strokeTaylor, Amanda ; Zorumski, Charles ; Sun, Min-Yu ; Mennerick, Steven
T-016328
— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…
Accurate, efficient 2D strain mapping with robust detection of strain localizationThomopoulos, Stavros ; Pless, Robert ; Genin, Guy ; Boyle, John
T-014090
— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…
Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer ImmunotherapyCuriel, David
T-011681
— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…
Applicator device for reducing artifacts in MR-guided gynecological brachytherapyGrigsby, Perry ; Zoberi, Jacqueline
T-011297
— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…
Therapy to treat and prevent respiratory disease in pre-term and at-risk neonatesTodd, Elizabeth (Betsy) ; Morley, Sharon "Celeste"
T-017434
— Technology Description Researchers in Prof. S. Celeste Morley’s laboratory have developed a long-lasting prophylactic therapy that could protect pre-term and at-risk infants from pneumonia, respiratory distress and bronchopulmonary dysplasia. Neonates born prematurely are at increased risk f…
High-performance, nanoengineered two-phase cooling system for high powered electronicsShan, Li ; Ma, Binjian ; Agonafer, Damena
T-018032
— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …
Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseasesLubman, Olga ; Lu, Yun Hsuan ; Fremont, Daved
T-017443
— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…
Small molecule inhibitors of G protein activity to treat uveal melanoma, and other cancers and disordersOnken, Michael ; Blumer, Kendall
T-017344
— Disease indication – Uveal melanoma and other G protein-driven disorders, including other cancers (certain vascular tumors, colon, lung, adenocarcinoma, skin melanoma, thyroid adenoma), cholera and Sturge-Weber Syndrome Drug format – small molecule (FR900359, a bioavailable inhibitor of…
Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disordersKotzbauer, Paul ; Yue, Xuyi ; Dhavale, Dhruva ; Tu, Zhude "Will"
T-018038
— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…
Breath-based testing for malariaTrehan, Indi ; Schaber, Chad ; John, Audrey Odom "Audrey Odom"
T-016183
— Technology Description Researchers in Prof. Audrey Odom John’s laboratory have discovered a malaria “breathprint” that could be used for blood-free, rapid, field-stable, point-of-care testing and monitoring. In addition, certain molecules identified by the inventors could attract…
Ultrasound “painting” for precise, targeted drug delivery to the brainYang, Yaoheng "Mack" ; Williamson, Jeffrey ; Chen, Hong
T-018953
— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…
Deep learning algorithm to expedite MRI-guided adaptive radiotherapy planningFu, Yabo ; Yang, Deshan
T-018708
— Technology Description Researchers in Prof. Deshan Yang’s laboratory have developed a deep-learning method for fast, robust, automated MRI segmentation to expedite treatment planning for patients undergoing MRI-guided adaptive radiotherapy (MR-IGART). Specifically, this technology utilizes a…
Hydrogel substrate system with easy, robust protein functionalization for cell cultureSarker, Bapi ; Pathak, Amit
T-018649
— Technology Description Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…
Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancersGrigsby, Perry
T-012905
— Technology Description Researchers in Dr. Perry Grigsby’s lab have developed a patented brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers. Gynecological cancers, such as recurrent endometrial and cervical cancers, can be treated with brachytherapy, but requir…
Low cost, high performance anion exchange membranes for grid-scale energy storage and other electrochemical devicesRamani, Vijay ; Parrondo, Javier ; Wang, Zhongyang
T-018608
— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a variety of robust, versatile anion exchange membrane (AEM) materials that achieve high performance through superior ion selectivity. These mechanically and chemically stable membranes have the potential to d…
Target and method to treat alphavirus infectionsKim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong ; Fremont, Daved ; Basore, Katherine ; Diamond, Michael
T-017583
— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…
Cytokine therapy for juvenile dermatomyositis and other autoimmune diseasesThrom, Allison ; Alinger, Joshua ; French, Anthony
T-018911
— Technology Description Researchers in Prof. Anthony French’s laboratory have discovered a signaling mechanism associated with juvenile dermatomyositis (JDM) that could potentially be targeted with cytokine-based therapies to treat JDM as well as other autoimmune disorders. This therapeutic a…
