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Washington University Satisfaction and Function SurveyBarrack, Robert ; Nunley, Ryan
T-015700
— Background: Over 7 million people in the United States are living with total hip (THR) or total knee (TKA) replacements. In the past decade, the number of THRs and TKAs have dramatically increased, particularly in the younger population. However, it is unclear if greater utilization of THRs and TKAs…
Spray Pyrolysis for the Production of Li+ Ion Battery CathodesElhassid, Dror ; Lengyel, Miklos ; Atlas, Gal ; Axelbaum, Richard
T-013647
— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…
Software to assemble HLA alleles using short paired reads from exome sequencing dataPfeifer, John ; Liu, Chang
T-013332
— Technology Description: In collaboration with the scientists at Broad Institute, WU scientists have developed a new software with a new algorithm that enables HLA high resolution typing from exome sequencing data. It will provide a significantly better tool to guide the bone marrow transplantation a…
Algorithm and alert process for the prediction and prevention in-patient Treatment-related severe hypoglycemiaTobin, Garry
T-012472
— Technology Description: A hospital-based algorithm and associated software that is able to predict which in-patients on diabetic therapy will develop hypoglycemia. It is able to predict in real time which patients are at risk and alert MDs to start interventions to prevent possible side effects or d…
Rat Hybridoma producing Monoclonal Antibodies against Mouse PDCA1Cella, Marina ; Blasius, Amanda ; Colonna, Marco
T-004377
— Target: Antibodies recognize a small leukocyte population of cells called intereron producing cells or plasmacyt-oid dendritic cells. Notes: Clone names 129c1 and 927Antibodies were produced by immunizing Wistar/CRL rats with CpG oligodeoxynucleotide 1826 or heat-killed Mycobacteria tuberculosis. The antibodies are specific for mouse IFN-producing cells (IPC). Publication: Bone Marrow Stromal Cell Antigen 2 Is a Specific Marker of Type I IFN-Producing Cells in …
IgG Monoclonal Antibodies to Enterococcus Faecalis GelatinaseShaikh, Nurmohammad ; Tarr, Phillip
T-011748
— Primary Inventor: Phillip I. Tarr, MD Target: GelE(mAb 8A3)Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…
Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detectionSong, Liang ; Rao, Bin ; Maslov, Konstantin ; Wang, Lihong
T-010922
— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…
Gaussian Process AudiogramWeinberger, Kilian ; Ledbetter, Noah ; Song, Xinyu ; Gardner, Jacob ; Barbour, Dennis
T-015053
— Technology Description: The current audiogram takes 20 minutes per employee per test. The Gaussian Process Audiogram is an improved system for conducting audiograms that would cut the test time in half while avoiding ‘false fails’. This is a machine learning approach to improve speed and…
Parallel single step prediction algorithm for conductivity-tensor estimationNehorai, Arye ; La Rosa Araya, Patricio ; Gilboa, Elad
T-011907
— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…
Algorithm for Multi-Agent Coordination Through Adaptively Regularized Parallel Distributed OptimizationGilboa, Elad
T-012524
— Many problems require the analysis of large, high-dimensional datasets, which make the problem intractable to most optimization algorithms. Gilboa has developed a new parallel distributed algorithm for block optimization problems using adaptive regularizer PDARÂ. PDAR is able to solve both t…
Quantify multi-tensor for improved CNS injury diagnosis using diffusion basis spectrum imaging (DBSI)Wang, Qing ; Wang, Yong ; Song, Sheng-Kwei "Victor"
T-009943
— Background: Diffusion tensor imaging (DTI) has demonstrated sensitivity to detect pathologies in CNS white matter disorders. However, the capability of DTI to detect CNS white matter pathologies is confounded by the coexisting structural (crossing fibers) and pathological (inflammation associated ce…
Flame Aerosol Reactor (FLAR) Based Process for Fabricating Nanostructured Films for Solar Energy Applications with Unique CompositionsThimsen, Elijah ; McDonald, Rafael ; Biswas, Pratim
T-006824
— The invention is a new process for fabricating nano-structured metal-oxide and other films. The films can harvest solar energy in the form of light and convert it to a more usable form (i.e: electricity or hydrogen gas). The films produced by this process have a unique morphology that grants them a …
Coupled Visualization and Ablation of Specific Cells and Tissues in ZebrafishSchroeter, Eric ; Mumm, Jeffrey
T-003399
— Background: Zebrafish is a standard model system in the field developmental biology and is particularly useful due to its extensive regenerative capabilities. The system has been used to study development by removal of cells by physical surgery and laser-mediated ablation; however these are labor in…
Managing Diabetes status in diabetic patientsRavi, V. Nathan
T-005389
— Background: About 422 million people worldwide and over 29 million Americans have diabetes. The prevalence of diabetes is increasing and an important cause of blindness, amputation, kidney failure, and one of the leading causes of premature death. Diabetes is associated with significant costs. In th…
Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteriesNorthrop, Paul ; Ramadesigan, Venkatasailanathan ; Suthar, Bharatkumar ; Lawder, Matthew ; De, Sumitava ; Subramanian, Venkat
T-013089
— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…
Disulfide trapped antigenic peptide in an MHC molecule.Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven ; Fremont, Daved ; Connolly, Janet ; Hansen, Ted
T-004551 Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Welch, Michael ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Fang, Huafeng ; Becker, Matthew ; Wooley, Karen
T-004487
— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.
Conformationally-flexible benzamide analogs as sigma-2 selective ligandsWelch, Michael ; Tu, Zhude "Will" ; Rowland, Douglas ; Mach, Robert
T-004063
— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …
Modulation of Lymphocyte ActivityYang, Jianfei ; Watanabe, Norihiko ; Murphy, Theresa ; Murphy, Kenneth
T-004061
— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…
Tri-heterocyclic ring compounds as alpha-synuclein ligandsYu, Lihai ; Mach, Robert ; Kotzbauer, Paul ; Tu, Zhude "Will"
T-011942
— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…