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Rotoscope – A Self-Cleaning Endoscope
Somers, Thane ; Yarbrough, Chester ; Margolis, Daniel ; Genin, Guy ; Leuthardt, Eric
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Plasma oxysterols as biomarkers for Niemann-Pick C disease
Ory, Daniel
T-007594

— Background Niemann-Pick type C is a rare, progressive neurodegenerative disease characterized by accumulation of cholesterol and other lipids in the viscera and central nervous system. For cases caused by mutations in the NPC1 or NPC2 gene, egress of lipids from endosomes or lysosomes are impaired, resulting in clinical symptoms such as abnormal eye movements, hearing loss, cerebellar ataxia, difficulty swallowing, and cognitive impairment. However, patients with Neimann-Pick disease have highly variable clinical presentation and symptom progression, making diagnosis challenging. Technology Summary A panel of oxygenated forms of cholesterol (oxysterols) in plasma that can be used as a diagnostic test for Neimann-Pick type C1 disease. The mass spectrometry-based panel is able to discriminate between subjects with NPC1 and normal control subjects. The oxysterol biomarkers have clinical utility in newborn screening for early diagnosis of NP1C disease, as markers for disease severity, and as biomarkers to aid in evaluation of new therapies for NPC1. Key Advantages High sensitivity Rapid diagnostic for screening infants Patents US 8,497,122 Issued US 9,012,216 Issued Publications Porter et al., 2010 – Cholesterol oxidation products are sensitive and specific blood-based biomarkers for NPC1 disease.

Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritis
Zhao, Guoyan ; Virgin, Herbert ; Finkbeiner, Stacy ; Wang, David
T-009294

— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…

Treatments for Wolfram syndrome
Mahadevan, Jana ; Clark, Amy ; Urano, Fumihiko
T-015862

— Technology Description Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…

Selective RANK ligand to treat osteoporosis
Warren, Julia ; Nelson, Christopher ; Fremont, Daved ; Teitelbaum, Steven
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Gehrig, Jeanette ; Venkatesh, Siddarth ; Chang, Hao-Wei ; Barratt, Michael ; Gordon, Jeffrey
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Tuning of photo-absorption in semiconductors, photoconductors, and other photo conversion systems using magnetic fields
Ramaswamy, Kannan ; Mui, Stacy ; Hayes, Sophia
T-008875

— Background: The idea of creating clean, sustainable power in high amounts from renewable energy sources is an interest among many across the globe. One of the many ways of creating renewable energy is applying the photovoltaic effect, the conversion of solar to electrical energy, by using semiconduc…

Mobile PET imaging system
Wen, Jie ; Mathews, Aswin ; Li, Ke ; Tai, Yuan-Chuan
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Pasque, Michael ; Cupps, Brian ; Kar, Julia
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Washington University Satisfaction and Function Survey
Barrack, Robert ; Nunley, Ryan
T-015700

— Background: Over 7 million people in the United States are living with total hip (THR) or total knee (TKA) replacements. In the past decade, the number of THRs and TKAs have dramatically increased, particularly in the younger population. However, it is unclear if greater utilization of THRs and TKAs…

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Lengyel, Miklos ; Elhassid, Dror ; Atlas, Gal ; Axelbaum, Richard
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

Software to assemble HLA alleles using short paired reads from exome sequencing data
Pfeifer, John ; Liu, Chang
T-013332

— Technology Description: In collaboration with the scientists at Broad Institute, WU scientists have developed a new software with a new algorithm that enables HLA high resolution typing from exome sequencing data. It will provide a significantly better tool to guide the bone marrow transplantation a…

Algorithm and alert process for the prediction and prevention in-patient Treatment-related severe hypoglycemia
Tobin, Garry
T-012472

— Technology Description: A hospital-based algorithm and associated software that is able to predict which in-patients on diabetic therapy will develop hypoglycemia. It is able to predict in real time which patients are at risk and alert MDs to start interventions to prevent possible side effects or d…

Rat Hybridoma producing Monoclonal Antibodies against Mouse PDCA1
Cella, Marina ; Blasius, Amanda ; Colonna, Marco
T-004377

— Target: Antibodies recognize a small leukocyte population of cells called intereron producing cells or plasmacyt-oid dendritic cells. Notes: Clone names 129c1 and 927Antibodies were produced by immunizing Wistar/CRL rats with CpG oligodeoxynucleotide 1826 or heat-killed Mycobacteria tuberculosis. The antibodies are specific for mouse IFN-producing cells (IPC). Publication: Bone Marrow Stromal Cell Antigen 2 Is a Specific Marker of Type I IFN-Producing Cells in …

IgG Monoclonal Antibodies to Enterococcus Faecalis Gelatinase
Shaikh, Nurmohammad ; Tarr, Phillip
T-011748

— Primary Inventor: Phillip I. Tarr, MD Target: GelE(mAb 8A3)Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…

Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
Song, Liang ; Rao, Bin ; Maslov, Konstantin ; Wang, Lihong
T-010922

— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…

Gaussian Process Audiogram
Weinberger, Kilian ; Ledbetter, Noah ; Song, Xinyu ; Gardner, Jacob ; Barbour, Dennis
T-015053

— Technology Description: The current audiogram takes 20 minutes per employee per test. The Gaussian Process Audiogram is an improved system for conducting audiograms that would cut the test time in half while avoiding ‘false fails’. This is a machine learning approach to improve speed and…

Parallel single step prediction algorithm for conductivity-tensor estimation
Nehorai, Arye ; La Rosa Araya, Patricio ; Gilboa, Elad
T-011907

— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…

Algorithm for Multi-Agent Coordination Through Adaptively Regularized Parallel Distributed Optimization
Gilboa, Elad
T-012524

— Many problems require the analysis of large, high-dimensional datasets, which make the problem intractable to most optimization algorithms. Gilboa has developed a new parallel distributed algorithm for block optimization problems using adaptive regularizer PDAR. PDAR is able to solve both t…

Quantify multi-tensor for improved CNS injury diagnosis using diffusion basis spectrum imaging (DBSI)
Wang, Qing ; Wang, Yong ; Song, Sheng-Kwei "Victor"
T-009943

— Background: Diffusion tensor imaging (DTI) has demonstrated sensitivity to detect pathologies in CNS white matter disorders. However, the capability of DTI to detect CNS white matter pathologies is confounded by the coexisting structural (crossing fibers) and pathological (inflammation associated ce…