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Sensitive and Accurate Mass Spec-based assay for simultaneous quantification of glycosylsphingosine and galactosylsphingosine
Jiang, Xuntian ; Ory, Daniel
T-016077

— Background Gaucher and Krabbe disease are two types of lipid (fat) storage diseases that can result in progressive damage to the nervous system and other organ systems. Together, these diseases affect about 450,000 people worldwide. In both of these diseases, there is an undesirable accumulation of…

Triblock Copolymer Based Anion Exchange Membranes (Aems) As Separators in Electrochemical Devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-017637

— Background: Anion exchange membranes (AEMs) are used as separators in redox flow batteries, water electrolyzers, water desalination systems, fuel cells, and other electrochemical devices. Current AEMs suffer from issues with cost, poor stability and low perm selectivity. For example, current redox flow batteries are not economical or suffer from capacity loss upon cycling due to cross species contamination while using less expensive decoupled chemistries.An advanced, tunable AEM has been developed with dramatically reduced cost and improved performance relative to industry leading AEMs. High ionic conductivity, chemical stability and enhanced mechanical performance have been shown. The technology includes tunable membrane compositions, mechanical re…

pTAT/pTAT-HA plasmids and protein purfication protocol (Vectors are on deposit with Addgene)
Dowdy, Steven
T-000717

— Technology Description: Researchers at Washington University have developed a method that allows the transduction of full-length proteins by utilizing the pTAT or pTAT-HA protein expression plasmids. A protein of choice can be fused to a HIV-TAT transduction domain under the expression system. Ba…

Microbiome Biomakers of Obesity
Turnbaugh, Peter ; Gordon, Jeffrey
T-007697

— Technology Summary: Obesity rates worldwide are increasing at an astounding rate. While diet, lifestyle, and physical activity have traditionally been identified as the main causative factors, researchers at Washington University are the first to implicate gut bacteria (microbiome) as a new drivin…

SILTmass software
Bateman, Randall ; Elbert, Donald
T-008416

— Background Quantitation of relative or absolute amounts of proteins by mass spectrometry can be prone to large errors. The use of MS/MS ion intensities and stable isotope labeling, a method called isotope labeling tandem mass spectrometry (SILT), decreases the effects of contamination from unrelate…

Universal Targeted Drug Delivery and Imaging Platform
Li, Ruihan ; Li, Xuesong ; Delawder, Abigail "Abby" ; Barnes, Jonathan
T-018548

— Background Targeted delivery of cytotoxic therapeutics is crucial to prevent adverse side effects of chemotherapy and to increase drug concentrations at the tumor site. These prerequisites also apply to the treatment of infections caused by multiple drug resistant bacteria. To address this unmet n…

Reproducible High Yielding Cu-64 Radioisotope Manufacturing
Lawrence, Luke ; Zerkel, Patrick ; Gaehle, Gregory
T-018514

— Background: Its unique imaging characteristics and favorable half-life and decay properties make radioisotope copper-64 (Cu-64) most desirable for PET imaging. To meet the increasing demand, an efficient high yielding Cu-64 manufacturing process is essential. To address this unmet need, scientists f…

CellTags: Tracking Individual Cells during Cell Reprogramming
Morris, Samantha
T-018555

— Background Cell populations are quite heterogeneous yet are typically analyzed in bulk, masking unique behavioral features. This is particularly problematic in cell reprogramming, where in a given population of cells, only a small number complete reprogramming. Single-cell technologies address the …

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Dunn, Gavin ; Petti, Allegra ; Chen, Hong ; Leuthardt, Eric
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic Diseases
Klechevsky, Eynav
T-016609

— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…

Tools for the Detection of High-Density Lipoprotein Transport To and From Tissues
Zinselmeyer, Bernd ; Huang, Li-Hao ; Randolph, Gwendalyn
T-015939

— Background High-density lipoproteins (HDLs) have been widely studied and linked to various diseases, especially metabolic diseases. HDL levels in the blood have traditionally been used as a benchmark for risk of cardiovascular disease. However, these blood tests may be misleading – HDL levels…

MicroRNA-induced Direct Conversion of Human Adult Fibroblasts into Neurons
Abernathy, Daniel ; Yoo, Andrew
T-017136

— Background: Studying late-onset neurodegenerative disorders using patient-specific neurons is one of the primary goals of precision medicine. The ability to generate human neurons that mimic the neurons of elderly individuals will provide an instrumental platform to model and study adult-onset neuro…

Comfortable radiotherapy couch to improve precision and accuracy
Mutic, Sasa ; Zhao, Tianyu
T-018538

— Background: High precision and accuracy is critically needed for the use of radiation treatment and diagnostic imaging (magnetic resonance imaging, computerized tomography, X-ray, positron emission tomography); each of these modalities uses the standard flat couch to manipulate the patient during pr…

Anti-PDZ TIP1 Antibody Therapy for Cancer
Yan, Heping ; Kapoor, Vaishali ; Hallahan, Dennis
T-017064

— Background: Lung cancer is one of the leading causes of cancer-related deaths worldwide. In the United States, it is second most common cancer for men and women and the leader for cancer-related death. Non-small-cell lung cancer (NSCLC) accounts for 85% of all reported lung cancer cases and is relat…

ID CUBE: Interactive Discovery Cube
Mishra, Deependra ; Wu, Qian ; Zhang, Hairong ; Garnett, Roman ; Huang, Yunshen ; Kim, David ; Du, Tommy ; Berezin, Mikhail
T-016317

— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…

Insert device that enhances MR and PET image resolution for MR-PET machines
Tai, Yuan-Chuan
T-007555

— Background PET-CT scanners have been widely used in the identification of tumors and localization for biopsies due to its superior ability to detect biochemical and physiological functions. However, one of the main limitations of PET-CT is the inability to visualize soft tissues, which may be impor…

Targeting B Cells for Antibody-Mediated Graft Rejection
Nelson, Christopher ; Wang, Xiaoli ; Edelson, Brian ; Fremont, Daved ; Liu, Chang
T-018682

— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …

Tumor treatment for patients with neurofibromatosis type 1 (NF1)
Gutmann, David ; Weber, Jason
T-007548

— Technology Description Scientists at the Washington University Neurofibromatosis Center have developed a patented, first-in-class method for treating neurofibromatosis type 1 (NF1) with small molecule inhibitors of targets in the mTOR (mammalian target of rapamycin) signaling pathway. NF1 is a rel…

Treatment for Age-Related Macular Degeneration (AMD) by Targeting Cholesterol Transport in Macrophages
Apte, Rajendra
T-011268

— Technology Description Researchers in Prof. Rajendra Apte’s laboratory developed novel methods for treating macular degeneration and other eye diseases by targeting a cholesterol transport pathway involved in the formation of new blood vessels. Age-related macular degeneration (AMD) is a lea…

MRI-based multiparametric cardiac strain analysis of myocardial viability
Cupps, Brian ; Pasque, Michael
T-006692

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…