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Flame Aerosol Reactor (FLAR) Based Process for Fabricating Nanostructured Films for Solar Energy Applications with Unique Compositions
Thimsen, Elijah ; McDonald, Rafael ; Biswas, Pratim
T-006824

— The invention is a new process for fabricating nano-structured metal-oxide and other films. The films can harvest solar energy in the form of light and convert it to a more usable form (i.e: electricity or hydrogen gas). The films produced by this process have a unique morphology that grants them a …

Coupled Visualization and Ablation of Specific Cells and Tissues in Zebrafish
Schroeter, Eric ; Mumm, Jeffrey
T-003399

— Background: Zebrafish is a standard model system in the field developmental biology and is particularly useful due to its extensive regenerative capabilities. The system has been used to study development by removal of cells by physical surgery and laser-mediated ablation; however these are labor in…

Managing Diabetes status in diabetic patients
Ravi, V. Nathan
T-005389

— Background: About 422 million people worldwide and over 29 million Americans have diabetes. The prevalence of diabetes is increasing and an important cause of blindness, amputation, kidney failure, and one of the leading causes of premature death. Diabetes is associated with significant costs. In th…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
Ramadesigan, Venkatasailanathan ; Suthar, Bharatkumar ; Lawder, Matthew ; Northrop, Paul ; De, Sumitava ; Subramanian, Venkat
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Disulfide trapped antigenic peptide in an MHC molecule.
Mitaksov, Vesselin ; Truscott, Steven ; Lybarger, Lonnie ; Miley, Michael ; Fremont, Daved ; Connolly, Janet ; Hansen, Ted
T-004551 Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Fang, Huafeng ; Pan, Dipanjan ; Becker, Matthew ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Tu, Zhude "Will" ; Welch, Michael ; Rowland, Douglas ; Mach, Robert
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

Modulation of Lymphocyte Activity
Watanabe, Norihiko ; Yang, Jianfei ; Murphy, Theresa ; Murphy, Kenneth
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

Tri-heterocyclic ring compounds as alpha-synuclein ligands
Yu, Lihai ; Mach, Robert ; Kotzbauer, Paul ; Tu, Zhude "Will"
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

Copy number Aberration Driven Endocrine Response (CADER) gene signature
Luo, Jingqin ; Ellis, Matthew
T-011920

— Identifying patients at risk of relapse while undergoing particular treatment protocols is critically important yet challenging to do in a timely manner. Researchers at Washington University have deveoped a new method to rapidly and accurately determine relapse risk in a human subject afflicted with…

Urinary Biomarker of Uropathogen Colonization
Parker, Kaveri ; Hung, Chia ; Henderson, Jeffrey P.
T-011741

— Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most common infectious diseases in women. The morbidity and economic impact are enormous, with over $2.5 billion spent annually on treatment. The high rates of recurrence, and the large numbers of women that …

Method for obtaining buoyant triacylglycerol-filled Chlamydomonas reinhardtii
Goodson, Carrie ; Goodenough, Ursula
T-011504

— There is currently keen interest in cultivating eukaryotic algae as sources of triacylglycerides (TAGs) to be converted into diesel and jet transportation fuel. Recent studies from numerous labs have shown that when stressed by nitrogen (N)-starvation, Chlamydomonas reinhardtii produce TAGs that ca…

MOR1D Mediates Opioid and Liver Disease-Induced Itch via GRPR
Liu, Xianyu ; Chen, Zhou-Feng
T-011473

— Background: Opioids, such as morphine, are used in pain management and have significant analgesic effects. However a common side effect of morphine is severe itching. Currently, morphine-induced itch is treated with antagonists against the mu opioid receptor. While these antagonists reduce itch, the…

Artificial Materials with Enhanced Nonlinearity
Ironside, Daniel ; Shen, Jung-Tsung
T-011141

— Background: Advances in nonlinear materials give rise to a multitude of optical phenomena that have important applications as switches and modulators in telecommunications and optical computing industry. The degree of optical nonlinearity in a material depends upon the strength of the optical field…

Autosegmentation tool
Rao, Yuan ; Ma, Daniel ; Grigsby, Perry
T-010736

— The technology encompasses a software method for automatically and interactively segmenting previously acquired medical images, including MRI and CT studies, based on edge and interior characteristics of regions. The method allows for arbitrary levels of sensitivity in differentiating areas of inte…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Assessment for Children
Umansky, Amy ; Jeffe, Donna ; Lieu, Judith
T-010222

— Approximately 5,000 infants are born with moderate, severe, or profound bilateral sensorineural hearing loss (HL) each year in the U.S. and many more have mild, unilateral, or progressive HL that will be identified in childhood. However, the degree of HL alone cannot predict a child’s language…

VarScan
Wylie, Todd ; McLellan, Michael ; Larson, David ; Ding, Li ; Koboldt, Daniel
T-009883

— arScan is a Java-based, platform-independent, software tool that can detect variants in next-generation sequencing (NGS) data. It employs a robust statistical approach to call variants and is able to handle germline variants, multi-sample variants, somatic mutations and somatic copy number alterati…

Graft-vs-Host Disease Prevention during Stem Cell Transplantation
Sandau, Michelle ; Albring, Jorn ; Murphy, Kenneth
T-009478

— Background: Allogeneic hematopoietic stem-cell transplantation (aHSCT) from a healthy donor can cure a variety of blood cell disorders including leukemia, multiple myeloma, and some types of lymphoma. This has resulted in an increasing number of transplants, surpassing 8,000 a year in the US alone. …

PET Radiotracers for Imaging Free Radicals and Reactive Oxygen Species (Materials: WC-4-77)
Mintun, Mark ; Dugan, Laura ; Chu, Wenhua ; Mach, Robert
T-009254

— Many diseases can be associated with abnormal production of reactive oxygen species (ROS) due to oxidative stress. Currently there is no way to image this in situ. Dihydroethidium (DHE) naturally produces a fluorescent product when oxidized by an ROS. The signal is not strong enough for practical im…

Planar storage phosphor dosimeter for radiation therapy dosimetry
Li, Hui
T-009252

— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…