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Personalized Virtual Reality TrainingJanes, William ; Foreman, Matthew ; Engsberg, Jack
T-014603
— Many patients require physical therapy each year as a result of their suffering from a variety of neurological and musculoskeletal disorders including stroke, cerebral palsy, trauma and many others. Repetitive movements can increase muscle tone, range of motion and stamina to aid in their daily act…
PEGylated-GIRLRG Peptide for Radiopharmaceutical DeliveryHallahan, Dennis
T-014562
— Technology: GRP78 is a chaperone that is part of a complex that controls the maturation of glycoproteins in the ER and senses cellular stress in normal cells. However, following radiation treatment, GRP78 is also expressed on the surface of cancer cells and has anti-apoptotic and pro-angiogenesis ac…
PARTNER programRook, Shannon ; Strunk, Robert ; Highstein, Gabrielle ; Dodd, Sherry ; Garbutt, Jane
T-014455
— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…
Red-Shifted Chromophore Substitution for Optogenetic ApplicationsToomey, Matthew ; Enright, Jennifer ; Corbo, Joseph
T-014377
— Optogenetics is one of the most important technological breakthroughs in neuroscience during the past decade, and holds tremendous promise for dissecting the mechanisms of neurologic disease and for treating a range of disorders. Optogenetic actuators are ion channels or pumps that can be regulated …
Ultra-Rare Variant Detection using Next Generation SequencingYoung, Andrew ; Druley, Todd
T-014312
— Next Generation Sequencing (NGS) allows rapid sequencing of an individual’s entire genome or portions of the genome to identify thousands of genetic variants. Personalized genomic tests based on NGS technologies can be used to predict an individual’s risk of disease or monitor disease pr…
Vaccines for the Pathogenic Fungus Cryptococcus Neoformans via Nasal InoculationUpadhya, Rajendra ; Lam, Woei Chuan ; Lodge, Jennifer
T-014064
— Cryptococcus fungi are pathogenic fungi that, unless treated, are invariably fatal to those individuals infected, particularly to those who are immunocompromised. Recent reports indicate that Cryptococcus fungi infects 1,000,000 individuals per year and causes approximately 600,000 deaths. While ant…
Parity-Time Symmetric Whispering-Gallery-Mode Microcavities SensorPeng, Bo ; Ozdemir, Sahin ; Yang, Lan
T-014053
— A non-reciprocal transmission device based on PT symmetry was previously theorized but never before constructed and shown to work at useful optical wavelengths. The new structure allows creation of the miniaturized optical isolation function without use of the century+ known Faraday effect. Optica…
Imaging and treatment of pathophysiologic conditions by Cerenkov RadiationKotagiri, Nalinikanth ; Achilefu, Samuel
T-013974
— Background: Around 1 million patients receive radiation therapy every year with an estimated cost of $2,000 per treatment. The market demands technologies that can provide efficacious therapeutics and diagnostic imaging while minimizing harmful side effects. Photodynamic therapy can simultaneously s…
8IGHT WAYS to Stay Healthy and Prevent DiseaseColditz, Graham
T-013927
— One important aspect for individuals to maintain health and prevent disease is through an educational understanding of making healthy choices while avoiding unhealthy choices. Clinicians at Washington University in St. Louis have created an evidence-based guide to disease prevention and healthy liv…
Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)Rachakonda, Tara ; Jeffe, Donna ; Lieu, Judith
T-013745
— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…
Fuel-Staged Oxy-Combustion Process and ApparatusXia, Fei ; Gopan, Akshay ; Kumfer, Benjamin ; Dhungel, Bhupesh ; Axelbaum, Richard
T-013736
— Technology Description: Washington University in St. Louis researchers have developed new technology for clean coal combustion. The Staged Pressurized Oxy-Combustion (SPOC) system, pioneered by researchers at Dr Axelbaum’s Laboratory for Advanced Combustion & Energy Research, provides a pa…
New diagnostic test method for infectious diseasesStorch, Gregory
T-013735
— Background: Viral infections are common causes of fever without an apparent source (FWS) in young children. Despite absence of bacterial infection, many febrile children are treated with antibiotics. Virus and bacteria interact with different pattern recognition receptors in circulating blood leuko…
Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data (combined with 013043)Schoonover, Robert ; Wang, Lihong ; Nie, Liming ; Huang, Chao ; Anastasio, Mark
T-013450
— Existing high-resolution human brain imaging modalities such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are expensive and employ bulky and generally non-portable imaging equipment. Moreover, X-ray CT is unsafe for patients who need long time monitoring of brain diseases …
Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral ContentThomopoulos, Stavros ; Smith, Lester
T-013230
— Background: Tissue engineered scaffold repair materials are currently modified with surface mineralization with simulated body fluids (SBF) of collagen provide a lower stiffness than desired in biosynthetic entheses and fail to replicate the naturally graded structure of the human connective tissue …
Multifunctional chemical agents for metal chelation, positron emission tomography (PET) imaging, fluorescence imaging, and amyloid plaque clearance in Alzheimer’s diseaseSharma, Anuj ; Schultz, Jason ; Mirica, Liviu
T-013190
— Alzheimer’s disease (AD) is characterized by the deposition of amyloid plaques containing the amyloid beta (Aβ) peptide. Currently, no treatment is available for AD. Metal ion interactions of the Aβ peptide are believed to help formation of toxic aggregates. Developing chemical compo…
A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinomaWang, Xiaowei
T-012911
— Oropharyngeal squamous cell carcinoma (OSCC) rates have increased significantly in recent years, and because of the different underlying causes of the disease no single treatment regime seems to be advantageous over another. Currently, the prognosis of OSCC is based on clinical features of the OSCC…
Photon tunnelingAn, Woo Jin ; Wang, Lihong
T-012515
— Photon tunneling has the potential to guide light to the core of a human body in vivo. Imaging, sensing, and therapy are among the applications for this technology. Light, as opposed to potentially harmful x-rays, is an ideal non-ionizing radiation for imaging and treating biological tissue, however…
Novel Murine AstrovirusesThackray, Larissa ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan ; Stappenbeck, Thaddeus ; Loh, Joy ; Virgin, Herbert
T-012077
— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…
Radiation Oncology Dashboards (LATTICE)Santanam, Lakshmi ; Scholle, Glen ; Mutic, Sasa ; Danieley, Jonathan ; LaBrash, Jason
T-014089
— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.
Optical Resolution Photoacoustic Imaging Device for Port-Wine StainsRao, Bin ; Maslov, Konstantin ; Wang, Lihong
T-012585
— A photoacoustic tomography device that provides high optical absorption contrast with high lateral resolution, including very good melanin distribution images, for port wine stain birthmarks.
