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“The Revolution Reservoir and Catheter Tip”: Non-clogging Shunt Catheter Tip for Improving SurgeryLimbrick, David ; Marcus, Richard ; McLaughlin, Aaron ; Moran, Daniel ; Shah, Manish ; Smyth, Matthew ; Stone, Samuel ; Wang, Lihong ; Winek, Michael ; Yang, Alexander ; Haydon, Devon ; Genin, Guy ; Leuthardt, Eric
T-011139
— Published date: 1/15/2025 Value Proposition: New device that will reduce or eliminate the need for repeated surgeries to clear blocked catheter tips in ventriculoperitoneal shunts. Technology Description Researchers at Washington University in St. Louis have developed a self-powered, rotating c…
Electrode Device that Precisely Stimulates Sympathetic Nerves to Treat Asthma, Hypertension and Other ConditionsMoran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher ; Kamath, Ashwin ; MacEwan, Matthew ; Moore, Amy ; Cloonan, Paige ; Leuthardt, Eric
T-017895
— Published date: 1/15/2025 Value Proposition: Implantable electrode device that can treat a plurality of medical diseases by stimulating or inhibiting select regions of sympathetic nervous system. Technology Description Researchers at Washington University in St. Louis have developed “SIMP…
Barbed Fixation Device for Improving Surgical SuturingFelder, John
T-018828
— Published date: 1/15/2025 Value Proposition: Barbed mesh wound closure device that eliminates the need for surgical suturing to close incisions of the skin and fascia. Technology Description Researchers at Washington University in St. Louis have developed a barbed rod device that can be used to …
Innovative Surgical Tool for Application of Bone Wax in Neurotologic and Skull Base SurgeryO'Connor, Zachary ; Shew, Matthew ; Kim, Albert ; Smetak, Miriam
T-020826
— Published date: 1/10/2025 Value Proposition: Novel instrument designed to improve application of bone wax during ear and lateral skull surgeries. Technology Description Researchers at Washington University in St. Louis have developed a novel surgical tool for bone wax application. Surgeries …
Osteogenic Screw System for Stimulating Bone GrowthMoran, Daniel ; Leuthardt, Eric
T-005419
— Published date: 1/9/2025 Value Proposition: Osteogenic device that provides a focal current through a bone construct to induce bone formation and fusion in patients. Technology Description Researchers at Washington University in St. Louis have developed an osteogenic screw system that can perfo…
Genetically Engineered Yeast Strain for the Treatment of Gastrointestinal Tumors with Immune Checkpoint Inhibitor TherapyKwak, Suryang ; Prusa, Jerome ; Wallace, Miranda ; Gorushi, Olivia ; Helmink, Beth ; Dantas, Gautam
T-020850
— Published date: 1/9/2025 Value Proposition: Genetically engineered yeast used to treat gastrointestinal tumors through the delivery of immune checkpoint inhibitor (ICI) proteins. Technology Description Researchers at Washington University in St. Louis have developed a genetically engineered …
Comprehensive Suite of Tools for Streamlining and Automating Testing of Radiotherapy MachinesHao, Yao ; Knutson, Nels ; Mutic, Sasa ; Rodriguez, Vivian ; Schmidt, Matthew ; Zhao, Tianyu ; Cai, Bin ; Green, Olga ; Sun, Baozhou
T-019435
— Value Proposition: Tool and software suite used to automate and improve testing quality of linear accelerators, thus increasing profit. Technology Description Researchers at Washington University in St. Louis have developed a comprehensive suite of hardware and software tools that enables ful…
Novel Combination Therapy that Improves Resistance to Tetracycline AntibioticsDantas, Gautam ; DeAngelo, Caitlin ; Williford, Emily ; Blake, Kevin ; Wencewicz, Timothy
T-020451
— Published Date: 1/4/2025 Value Proposition: New composition of matter that combines tetracycline class compounds with destructase inhibitors to overcome resistance to tetracycline antibiotics. Technology Description Researchers at Washington University in St. Louis have developed an enzymatic…
Zbtb46: A Novel Target for Cancer TherapyKrchma, Karen ; Kabir, Ashraf Ul ; Choi, Kyunghee
T-020458
— Published Date: 12/31/2024 Value Proposition: Novel immune-gene therapy for treatment of cancer. Technology Description Solid neoplasms are difficult to treat using immune checkpoint inhibitors in part because of the immunosuppressive nature of the tumor microenvironment. Researchers at Washin…
Method for Pattern Generation in Temperature-Dependent Viscosity Fluids Utilizing Localized Convective CellsJain, Chhavi ; Solomatov, Viatcheslav
T-021221
— Technology Description Researchers at Washington University in St. Louis have developed a process for manufacturing molten materials, such as molten polymers, to create patterns. By controlling the temperature of a molten polymer and applying targeted heat pulses from lasers or other sources, th…
Retrograde-AAV Platform that Enables Multiplex Projection Tracing and Multi-Modal Profiling of Projection NeuronsLiu, Fang ; Yang, Lite ; Hahm, Hannah ; Samineni, Vijay
T-020975
— Published Date: 12/21/24 Value proposition: Powerful, high throughput platform that allows for the multiplex tracing of projection neurons to obtain a snapshot of activity-dependent recruitment of distinct projection neurons and their molecular features. Technology Description Researchers at…
Protein Used to Enhance T cell Expansion to Improve Cancer ImmunotherapyChou, Chun ; Egawa, Takeshi
T-016284
— Published Date: 12/19/2024 Value Proposition: This invention utilizes a protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapy. Technology Description Researchers at Washinton University in St. Louis have developed a mutant AP4 protein that is desig…
New Approach for the Treatment of Brain CancersLi, Yuping ; Curiel, David ; Diamond, Michael ; Chheda, Milan
T-021004
— Published Date: 12/20/2024 Value Proposition: Treats brain tumors by combining a hematopoietic growth protein and cancer therapeutics to increase survival rates. Technology Description Researchers at Washington University in St. Louis have developed a new way to treat brain cancers by combining…
Super Resolution cine MRI for Improving Image Quality and Tumor Targeting During RadiotherapyKim, Taeho
T-019747
— Published Date: 12/18/2024 Value Proposition: First clinical application of super resolution (SR) MRI reconstruction for 2D cine MRI in real-time radiotherapy. Technology Description Researchers at Washington University in St. Louis have developed a novel application for super-resolution (SR) c…
New Process to Diagnose Several Classes of Tauopathies in the BrainHorie, Kanta ; Mukherjee, Soumya ; Bateman, Randall ; He, Yingxin "Chloe" ; Barthelemy, Nicolas
T-020932
— Published Date: 12/19/2024 Value proposition: Novel method used to detect tau proteins in the brain using biofluids. Technology Description Researchers at Washington University in St. Louis have developed a method to identify and differentiate primary and secondary tauopathies in the brain. Man…
Procedure to Improve the Performance of On-table Adaptive RadiotherapySchmidt, Matthew ; Kim, Taeho
T-019735
— Published Date: 12/19/2024 Value Proposition: First clinical application of super resolution (SR) MRI reconstruction for 2D cine MRI in real-time radiotherapy. Technology Description Researchers at Washington University in St. Louis have developed a novel application for super-resolution (SR) c…
Mechanically Optimized Synthetic Dendritic Cells for the Expansion of Antigen-Specific T CellsSarker, Bapi ; Klechevsky, Eynav ; Pathak, Amit
T-017391
— Published Date: 12/19/2024 Value Proposition: New method for expanding T cells against individualized tumor-specific mutational antigens. Technology Description Researchers at Washington University in St. Louis have developed a device that enables high-throughput production of patient specific …
New Method for Predicting a Patient’s Response to Drug Therapy for Treatment of Irregular Heart RhythmsZhu, Wandi ; Naegle, Kristen ; Silva, Jonathan
T-018631
— Value Proposition: New process that uses ion channel voltage sensing parameters to predict antiarrhythmic drug response. Technology Description Researchers at Washington University in St. Louis have developed a new process for predicting patients’ response to mexiletine drug therapy. Mexil…
New Process for Treating Multiple MyelomaSilva-Fisher, Jessica
T-020751
— Value Proposition: Long non-coding RNA as biomarker and therapeutic target for treating diagnosed multiple myeloma patients. Technology Description Researchers at Washington University in St. Louis have developed a long non-coding RNA as a diagnostic marker and clinical target for multiple my…
Small Molecule Gastrin-releasing peptide receptor (GRPR) antagonists used for Anti-Itch TreatmentDolle, Roland "Ron" ; Zhou, Mingzhou
T-020002
— Value Proposition: Small molecule Gastrin-releasing peptide receptor (GRPR) antagonists used to treat chronic itch. Technology Description Researchers at Washington University in St. Louis have discovered a group of small molecule Gastrin-releasing peptide receptor (GRPR) antagonists to treat c…
