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Neuroactive steroid anesthetic compoundsJiang, Xin ; Covey, Douglas
T-004034
— Technology Description Researchers at Washington University have developed a range of steroid anesthetic agents that share known neurosteroid structures but are more potent. These compounds share the basic structure of neurosteroids alphaxalone, allopregnanolone, and ent-androsterone, but the stru…
ME1 Deficiency Primes for FerroptosisLange, Sara ; Kremer, Jeff ; Van Tine, Brian
T-016416
— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…
JAK inhibitor as conditioning agent for allogeneic hematopoietic stem cell transplantationDiPersio, John ; Persaud, Stephen "Steve"
T-019132
— Technology Description Researchers at Washington University in St. Louis have developed an improved process for conditioning patients for allogeneic hematopoietic stem cell transplantation (alloHSCT) using JAK inhibitors. Commonly used to treat autoimmune diseases like rheumatoid arthritis, JAK inh…
NanoTCE: a nanoparticle antibody system for immunotherapy against heterogeneous multiple myelomaAlhallak, Kinan ; Azab, Abdel Kareem
T-018892
— Disease indication – multiple myeloma Drug format – antibodies conjugated to nanoparticles for T-cell immunotherapy Drug class – improved delivery platform Research stage and Preliminary data: In vivo: In vitro proof of concept – in a MM cell line: NanoMuTEs and NanoTC…
MRI-based Alzheimer’s disease biomarkers for early diagnosis and clinical trialsZhao, Yue ; Yablonskiy, Dmitriy
T-015754
— Technology Description Researchers in Prof. Dmitriy Yablonskiy’s laboratory have developed patented neuroimaging techniques to identify pre-clinical and early stage Alzheimer’s disease (AD) using MRI-based biomarkers of amyloid accumulation and other pathological changes in the brain. …
CCR2-targeted cancer nanoimmunotherapyZhang, Xiaohui ; Lim, Kian-Huat ; Liu, Yongjian
T-019463
— Disease indication – Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide Drug class – First-in-class Target – CCR2, the receptor for CCL2 Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…
Toolkit to efficiently design exact pulse code sequences for MRI, NMR or quantum computingLi, Jr-Shin
T-017456
— Technology Description Engineers in Prof. Jr-Shin Li’s laboratory have developed a computationally efficient analytical technique to design exact RF pulse code sequences which optimize quantum applications such as MRI for medical diagnosis, NMR spectroscopy for uncovering protein structures …
Small molecules targeting KCNQ in ventricular arrhythmiaCui, Jianmin
T-013554
— Disease indication – Long QT Syndrome (resulting in ventricular arrhythmia, epilepsy, deafness) Drug format – Small molecule Drug class – Lead compounds are repurposed drugs Research stage and preliminary data – Based on in silico screening of KCNQ, the researchers selecte…
Real-time interference compensation in MRI guided radiotherapyKim, Taeho ; Villa, Umberto ; Curcuru, Austen ; Gach, H. Michael
T-019745
— Technology Description Researchers at Washington University in St. Louis have developed a method to improve image quality during MR imaging guided radiation therapy (MR-IGRT) by correcting for B0 fluctuation in real-time. The corrections reduce electromagnetic interference (EMI) between the MRI sc…
Low-cost, synthetic hydrogel scaffold to promote nerve growth and regenerationRoam, Jacob ; Elbert, Donald
T-016599
— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…
Therapeutic targeting of LDL in ALSNielsen, Susan ; Racette, Brad ; Kreple, Collin ; Miller, Timothy
T-020021
— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…
IP-10 as a blood biomarker of respiratory failureMudd, Philip
T-019671
— Technology Description Researchers in Philip Mudd’s lab at Washington University have developed a blood biomarker test that detects impending respiratory failure before existing diagnostics. High levels of the biomarker IP-10 in the blood are correlated with the subsequent development of acu…
Cell-based tumor targeting for delivering therapeutic and imaging agentsMuz, Barbara ; Azab, Abdel Kareem
T-018893
— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…
Targeted liposome drug delivery system to improve multiple myeloma treatmentFederico, Cinzia ; Azab, Abdel Kareem
T-019089
— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…
Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applicationsGarcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872
— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…
Controlling charge doping in 2D materialsBalgley, Jesse ; Henriksen, Erik
T-019602
— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…
Rechargeable anode-free sodium metal batteryMa, Bingyuan ; Lee, Youngju ; Bai, Peng
T-019512
— Technology Description Researchers in Peng Bai’s lab at Washington University have developed an inexpensive rechargeable sodium metal battery with a 99.93% sodium retention rate. This battery uses glyme-based electrolytes with a low moisture content and a bare copper current collector to ach…
Rational drug design using Boltzmann dockingBowman, Gregory
T-016234
— Technology Description Researchers in Greg Bowman’s lab at Washington University have developed an improved method for rational drug and protein design called Boltzmann docking. This process better incorporates the dynamic structures of proteins to identify sites for binding that are not rev…
Improved MRI resolution with Diffusion Dictionary Imaging (DDI)Wang, Qing ; Wang, Yong
T-019608
— Technology Description Researchers at Washington University in St. Louis have developed MRI post-processing software capable of imaging cellular components. The software matches specific patterns with a dictionary of signals corresponding to cellular components. While the researchers have previous…
SPARTA – A Stent for Fusiform Aneurysms that Prevents EndoleaksElbert, Donald ; Genin, Guy ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory ; Derdeyn, Colin ; Bayly, Philip ; Leuthardt, Eric
T-015969
— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…
