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TREM2 blockade as an adjuvant for checkpoint inhibitorsColonna, Marco
T-019371
— Disease indication – In combination with anti-PD-1 therapy for cancer. Anti-PD-1 therapy is currently approved for: Drug format – Monoclonal antibody Drug class – First-in-class Target – TREM2 Research stage and preliminary data – The inventors performed initia…
Stimulating Innate Immune Cells for Cancer Therapy or Vaccine AdjuvantsBarrow, Alexander ; Colonna, Marco
T-016924
— Technology Description Researchers in Prof. Marco Colonna’s laboratory have identified a receptor-ligand interaction that could be harnessed to activate the innate immune system to treat cancer or enhance the response to vaccines for infectious disease. Specifically, platelet-derived growth f…
SARS-CoV-2 neutralizing antibody effective against all variantsVanBlargan, Laura ; Fremont, Daved ; Adams, Lucas ; Diamond, Michael
T-019791
— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…
Software to predict low back pain from brain imagingRay, Wilson ; Lamichhane, Bidhan ; Leuthardt, Eric ; Jayasekera, Dinal ; Hawasli, Ammar
T-019322
— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…
Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imagingMutch, Matthew ; Uddin, Shihab ; Leng, Xiandong ; Chapman Jr., William "Will Jr" ; Zhu, Quing
T-019449
— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…
Peptides responsible for Type 1 diabetesWan, Xiaoxiao ; Lichti, Cheryl ; Unanue, Emil
T-018626
— Technology Description: Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …
Photothermal disinfection of N95 respiratorsSingamaneni, Srikanth ; Jun, Young-Shin
T-019477
— Technology Description A team of researchers led by Young-Shin Jun have developed a polymer coating for N95 respirators that would permit fast, easy, and cheap N95 disinfection using only direct sunlight. The researchers coated the outermost fabric layer in polydopamine, which converts photon energ…
Self-powered, solid-state devices for remote sensing, timing and security of internet-of-things and other passive assetsZhou, Liang ; Chakrabartty, Shantanu
T-015908
— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a self-powered, CMOS-based, nano-scale “smart sensor” and timer system that uses quantum-tunneling for reliable, long-lasting memory or authentication. This technology is a floating gate …
Simple, universal DNA motifs for modulating protein productionDjuranovic, Sergej
T-016819
— Technology Description Researchers in Prof. Sergej Djuranovic’s laboratory have discovered short DNA coding motifs that can increase or decrease expression of recombinant proteins by 3-4 orders of magnitude in a variety of organisms. Together, these universal tools can provide tightly contro…
Energy efficient, scalable neuromorphic computing with Growth Transform Neural NetworkGangopadhyay, Ahana ; Chakrabartty, Shantanu
T-019112
— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed Growth Transform Neural Network (GTNN), a flexible system for designing scalable neuromorphic processors for use in deep learning systems and support vector machines. GTNN frames the neuromorphic syst…
Robust, scalable phase control system for non-invasive neuromodulation devicesZlotnik, Anatoly ; Li, Jr-Shin
T-016206
— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …
Water filtration platform technologies using crumpled graphene oxide nanocompositesWang, WeiNing ; Jiang, Yi ; Fortner, John ; Biswas, Pratim
T-014428
— Technology Description A team of researchers at Washington University, led by Pratim Biswas and John Fortner, has constructed crumpled graphene oxide nanoparticles encapsulating TiO2 and Ag to create reactive, easily cleaned water filtration membranes. The TiO2 and Ag, which can be periodically re…
A Highly Efficient Brine ElectrolyzerSankarasubramanian, Shrihari ; Gayen, Pralay ; Ramani, Vijay
T-019234
— Technology Description Researchers in the Ramani lab at Washington University have developed an electrolyzer capable of selectively splitting salty or brackish water into ultra-pure hydrogen and oxygen at high operating power densities. Originally designed to tap the perchlorate-rich water on the …
Lightweight, wearable cap for bedside functional optical neuroimagingFerradal, Silvina ; Eggebrecht, Adam ; Bergonzi, Karla ; Culver, Joseph
T-013611
— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …
Efficient multi-dimensional 4D MRI and PET/MR motion correctionEldeniz, Cihat ; An, Hongyu
T-016414
— Technology Description Researchers in Prof. Hongyu An’s laboratory have developed a new image processing system for faster acquisition of motion-corrected MR or PET/MR images. This technology could be expanded to multiple sampling schema to correct both respiratory and cardiac motion. Liv…
MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluationBaldelomar, Edwin ; Bennett, Kevin
T-019017
— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…
Method of increasing chemotherapy sensitivity in leukemia using BET inhibitorWilkinson, Michael Nathaniel ; Moudgil, Arnav ; Mitra, Robi
T-019486
— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …
Fusion protein for treating multiple strains of Venezuelan equine encephalitis virusKafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa ; Fremont, Daved ; Basore, Katherine ; Diamond, Michael
T-019414
— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …
PI3K inhibitors to treat Cytokine Release SyndromeCarter, Alun ; DiPersio, John ; Amatya, Parmeshwar ; Cooper, Matthew
T-019429
— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…
Plasmids to express tagged genes in yeastWhite, Michael A ; Roy, Basab ; Granas, David ; Stormo, Gary
T-019559
— Three yeast plasmids that express yeast genes tagged with the fluorescent mCherry protein under the control of the GAL promoter. The genes were modified to be cre-less to so the plasmids could be used to study autoregulation in yeast. pMBJ1 pMBJ1-RPL1B-cl pMBJ1-RPS22-cl Publication: Roy, B., Gr…
