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Antibodies that can Identify C. Acnes InfectionsIlagan, Maxenia ; Aleem, Alexander ; McCoy IV, William
T-020481
— Value Proposition: This invention uses antibodies to detect Cutibacterium acnes (C. acnes) infections. Technology Description Researchers at Washington University in St. Louis have developed antibodies that can identify Cutibacterium acnes (C. acnes), which opportunistically causes infection rang…
New Process for Diagnosing Abnormal Heart Rhythms AutomaticallyMay, Adam
T-019674
— Technology Description Researchers at Washington University in St. Louis have developed a new method for automatically differentiating accelerated heart rhythms caused by wide complex tachycardia (WCTs) into fast, or irregularly fast heart rhythms caused by ventricular tachycardia (VT) and suprave…
Software that Generates Radiology Reports using Deep LearningRahbar, Kasra ; Kansagra, Akash
T-018976
— T-018976 Software that Generates Radiology Reports using Deep Learning Technology Description Researchers at Washington University in St. Louis have developed a computational software method designed to assist radiologists with generating and correcting patient reports more effectively. Radiolo…
Deep Tissue Diagnostics with Disposable Fiber-Optic DeviceYang, Shuo ; Ling, Jingwei ; Hu, Song
T-020656
— T-020656 – Deep Tissue Diagnostics with Disposable Fiber-Optic Device Technology Description Researchers from the laboratory of Song Hu has developed a miniaturized fiber-optic device capable of minimally invasive measurements of deep-tissue biomechanical properties. The device can be rea…
Lrp1 and the Blood Brain BarrierVirgin, Herbert ; Ganaie, Safder ; Leung, Daisy ; Amarasinghe, Gaya
T-019577
— T-019577 – Lrp1 and the blood brain barrier Technology Description Researchers in Gaya Amarasinghe’s laboratory at Washington University have engineered new protein fragments (RVFV Gn) to target LRP1, which was recently identified as an essential entry factor for Rift Valley Fever Virus (RVF…
Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem CellsLuff, Stephanie ; Sturgeon, Christopher
T-018886
— T-018886 — Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem Cells Technology Description In vitro generation of CD34+ hematopoietic progenitor cells (HPC) that faithfully recapitulate in vivo behavior is an area of ongoing research. A key characteristic of CD34+ …
Radiotracers to detect early Parkinson’s diseaseQiu, Lin ; Yu, Yanbo ; Kotzbauer, Paul ; Tu, Zhude "Will"
T-020559
— Radiotracers to detect early Parkinson’s disease Technology Description Researchers at Washington University in St. Louis, led by Dr. Zhude Tu, have developed two imaging agents for α-synuclein (α-syn) aggregation for use to diagnose early Parkinson’s disease, track dise…
Engineered Oncolytic Zika Virus Therapy for GlioblastomaGorman, Matthew ; Chheda, Milan ; Diamond, Michael
T-017429
— T-017429 Engineered Oncolytic Zika Virus Therapy for Glioblastoma Technology Description Researchers in the laboratories of Michael Diamond and Milan Chheda at Washington University have developed prospective treatments for glioblastoma (GBM) through the application of an engineered Zika virus (ZI…
Myocardial perfusion SPECT optimizationSiegel, Barry ; Yu, Zitong ; Rahman, Md Ashequr ; Jha, Abhinav Kumar
T-020357
— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…
Small Molecule Agonists of EphA Receptors to Ameliorate DiabetesAsadi Jomnani, Farzad ; Dolle, Roland "Ron" ; Piston, David
T-020153
— T-020153 – Small Molecule Agonists of EphA Receptors to Ameliorate Diabetes Technology Description Blood glucose levels (left), post-treatment plasma glucagon (center) in WCDD301 treated NOD (non-obese diabetic) mice with moderate hyperglycemia. Blood glucose levels (right) in Streptozotocin-ind…
Systems and Methods for Detection and Quantification of Axial SpondyloarthritisYokoyama, Wayne ; Paley, Michael
T-020486
— T-020486 – Systems and Methods for Detection and Quantification of Axial Spondyloarthritis Technology Description Researchers at Washington University in St. Louis, led by Dr. Michael Paley, have developed an assay to diagnose axial spondyloarthritis (axSpA) in HLA-B*27-positive patients.…
Robust Suite of Technologies Offers Significant Enhancements for Whispering Gallery Mode (WGM) Microresonator Sensors and Laser SystemsYang, Lan ; He, Lina ; Ozdemir, Sahin ; Chen, Da-Ren ; Zhu, Jiangang
T-009642
— WGM microresonators are an immature technology with room for improvement Microresonators are optical devices that are an important component of microlasers used in optoelectronics, data communications, and sensing. Most microresonators are WGM type, which confine light to a very small volume for si…
Development of CD163 targeting agent for imaging and therapyZhang, Xiuli ; Heo, Gyu Seong ; Liu, Yongjian
T-020196
— T-020196 CD163 Targeting Agent for Imaging and Therapy Technology Description Researchers in Yongjian Liu’s laboratory at Washington University have synthesized a new peptide-based CD163 radiotracer. CD163 is a well-known biomarker specific to macrophages implicated in multiple diseases, but…
Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammationSivapackiam, Jothilingam ; Sharma, Vijay
T-019479
— T-019479 Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammation. Technology Description 18F-fluorodeoxyglucose (18F-FDG) has long been used for the diagnosis of neoplasms, and recently Alzheimer’s disease. However, 18F-FDG signals are often not correlated with…
PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen SpeciesSivapackiam, Jothilingam ; Satham, Lakshminarayana ; Sharma, Vijay
T-020300
— T-020300 PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen Species Technology Description Reactive Oxygen Species (ROS) is known to contribute to the pathogenesis of neuropathological conditions such as Alzheimer’s disease and cancer. However, there …
Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased ProfitabilityRaman, Caleb ; Reynoso, Francisco ; Sun, Baozhou ; Wu, Yu ; Knutson, Nels ; Mahon, Rebecca "Nicky" ; Hao, Yao ; Schmidt, Matthew
T-019746
— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…
Uropathogen VaccinesFeldman, Mario ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan ; Dodson, Karen ; Ellebedy, Ali ; Hultgren, Scott
T-020120
— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…
Super-Resolution Dental Tetrahedron Beam Computed Tomography (TBCT) System Improves Image Quality Without Sacrificing Speed for Expanded Clinical ApplicationsZhou, Shuang ; Chen, Qinghao ; Tan, Yuewen ; Zhang, Tiezhi
T-019620
— Current cone beam computed tomography (CBCT) systems lack concurrent high-resolution imaging and speed With current digital CBCT imaging technology, x-ray tube power limitations mean high-resolution images can only be achieved by reducing imaging speeds. In dental applications, CBCT suffers from im…
MRI neural network segmentation in atherosclerosisLi, Ran ; Zheng, Jie ; Jha, Abhinav Kumar ; Woodard, Pamela
T-020254
— Technology Description Researchers at Washington University in St. Louis have developed a two-stage neural network model, with CNN and BNN architecture, to segment carotid atherosclerotic plaque components based on multi-weighted MR images and measure the uncertainty of the segmentation output. Th…
Optimized Non-Coplanar Radiation Delivery for Simpler, Faster, and Safer TreatmentsMutic, Sasa ; Zhang, Tiezhi
T-016307
— Existing LINACs inefficiently deliver non-coplanar beams The goal of radiation treatment is to precisely deliver a prescribed radiation dose to the targeted tissue, while avoiding dosing the surrounding normal tissues and organs. These treatments require radiation beams to be delivered from multipl…
