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Plasmid to test regulation 5′ untranslated sequences in yeast
White, Michael A ; Roy, Basab ; Granas, David ; Stormo, Gary
T-019560

— This plasmid was created to test the regulatory impact of 5’ untranslated regions in yeast. It consists of EGFP under the control of the S. cerevisiae TEF2 promoter with cloning sites to modify the 5’UTR. Publication: Roy, B., Granas, D., Bragg, F., Cher, J. A., White, M. A., & Stor…

CD226 (DNAM1) knockout mice
Gilfillan, Susan ; Colonna, Marco
T-019563

— This is a mouse knockout strain for CD26, also known as DNAM-1 (DNAX accessory molecule 1). DNAM-1 is an adhesion molecule belonging to the immunoglobulin superfamily. This mouse model was used to study the role of DNAM-1 on CD8 T cell and NK cell function in vitro and in vivo. Publication: Gilfill…

CHIKV-3’Cre – recombinant Chikungunya virus expressing Cre
Lenschow, Deborah
T-019567

— This is a recombinant clone of the Chikungunya LR2006 virus expressing Cre recombinase inserted downstream of a subgenomic promoter. In vitro transcription and transfection of RNA derived from this plasmid into cells will result in the generation of Chikungunya virus that expresses Cre recombinase i…

IL-34-deficient reporter mice (IL34 LacZ/LacZ)
Colonna, Marco
T-019588

— Mouse strain deficient in IL-34 production with defective Langerhans cells and microglia. These mice can be used to assess the role of the cytokine IL-34 in the development and maintenance of peripheral macrophage populations. Publication: Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossin…

Ebola VP30 proteins
Amarasinghe, Gaya
T-019593

— Ebola viral protein 30 (eVP30) plays a critical role in transcription initiation for viral RNA synthesis. These materials could be used to test for Ebola virus infection. Publication: Xu, W., Luthra, P., Wu, C., Batra, J., Leung, D. W., Basler, C. F., & Amarasinghe, G. K. (2017). Ebola virus VP…

Broad spectrum chemokine receptor imaging agent
Liu, Yongjian
T-019607

— 64Cu-DOTA-vMIP-II is a broad spectrum PET imaging agent that provides a non-invasive measurement of up to 10 chemokine receptors involved in the inflammatory processes of various diseases. This agent is based on the peptide vMIP-II (viral macrophage inflammatory protein-II), a viral CC chemokine enc…

ACE2 expressing cells
Kumar, Sandeep ; Peterson, Timothy
T-019619

— These cells are K562 cells that express ACE2 (the receptor for SARS-CoV-2) from the endogenous locus and not a transgene.

CEPT1 floxed mice
Lodhi, Irfan ; Semenkovich, Clay
T-019637

— C57BL/6 ES cells were targeted with a vector (European Conditional Mouse Mutagenesis Program) carrying loxP sites flanking exon 3 of mouse Cept1. A karyotypically normal clone (of 10 correctly targeted) was injected into B6(Cg)-Tyrc-2J/J blastocysts and chimeric mice were bred with B6(Cg)-Tyrc2J/J f…

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development
Veronese Paniagua, Daniel ; Wernes, Kristina ; Velazco-Cruz, Leonardo ; Hogrebe, Nathaniel ; Millman, Jeffrey
T-019409

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

An Intradermal Method for the Treatment of Hair Loss and Alopecia
Yang, Pu ; Luo, Jialie ; Feng, Jing ; Hu, Hongzhen
T-017716

— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…

Early, specific, blood-based diagnostic for septic arthritis
Luhmann, Scott
T-018905

— Technology Description: Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Rettig, Michael ; Ley, Timothy ; Petti, Allegra ; DiPersio, John ; Christopher, Matthew
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Hartquist, Chase ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed ; Genin, Guy ; Hafez, Daniel ; Chandrasekaran, Vinay ; Leuthardt, Eric
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Barbed mesh for fast, suture-less surgical wound closure
Felder, John
T-018828

— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…

Single cell calling cards (scCC): Transposon system to simultaneously map transcription factors and quantify gene expression
Wilkinson, Michael Nathaniel ; Qi, Zongtai ; Moudgil, Arnav ; Mitra, Robi
T-018609

— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Milbrandt, Jeffrey ; Mitra, Robi ; Lalli, Matthew ; Buchser, William
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

Atrial fibrillation treatment with patient-specific model to design ablation lesions
Schuessler, Richard ; Damiano, Ralph
T-005819

— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…

Computer vision training system for robust artificial intelligence image classification
Wu, Tong ; Tong, Liang ; Vorobeychik, Yevgeniy
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Error correcting codes for robust, secure deep neural networks
Raviv, Netanel
T-019252

— Technology Description Researchers in Prof. Netanel Raviv’s laboratory have developed a provable error correcting code (ECC) system that could guarantee deep neural networks (DNN) are resilient to noise for robust, secure and private neural computation. This technology could be deployed in n…

Split intein synthetic biology platform for scalable microbial production of high-performance biomimetic textiles, adhesives and other materials
Dai, Bin ; Bowen, Christopher ; Zhang, Fuzhong
T-018602

— Brief Description A team of engineers at Washington University in St. Louis have developed a synthetic biology platform for low-cost, sustainable production of high-performance composite materials. This technology uses a split intein assembly system to synthesize high molecular weight polymers (e.…