— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…
— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …
— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…
— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…
— This panel of antibodies against the SARS-CoV-2 spike protein has potential applications for research or diagnostics (e.g., sandwich ELISA to quantify or detect spikes in biological fluid).
— This is a large panel of variants in the SARS-CoV-2 spike protein incorporated into a VSV-vector. These were largely selected as escape mutants to neutralizing antibodies or were designed to probe the function of circulating viral variants. These constructs can be used to screen antibodies and solub…
— The creators used homologous gene recombination to delete the gene encoding inositol phosphoryl ceramide synthase (IPCS) from the genome of the protozoan parasite Leshmania major.
— The creators used classical homologous recombination to remove both copies of the Leishmania major target of rapamycin (TOR3). This mutant was used to study TOR3’s suitability as a potential drug candidate. Da Silva, L. M., & Beverley, S. M. (2010). Expansion of the target of rapamycin (T…
— Genetically engineered mice and frozen sperm with two loxP sites flanking the mouse Wfs1 gene. These mice can be used to study the mechanisms of neurodegeneration in Wolfram syndrome.
— This is the pcDNA-5 plasmid library with 6500 barcoded constructs containing eGFP followed by 650 combinations of 3’UTRs with miRNA, Pumilio, Smaug and AU-rich. This library can be used to optimize gene expression and to study gene regulation by different micro RNAs and RNA-binding proteins. …
— Leishmania guyanensis strain M4147 (+/- LRV) engineered to express two markers, mCherry and firefly luciferase. The constructs are stably integrated into the ribosomal RNA SSU locus. Parasites with these markers can be followed by fluorescence or bioluminescence approaches which is faster and requir…
— This VSV-SARS1 chimeric virus is a biosafety level 2 reporter of SARS COV 1 infection. It could be used to study shared mechanisms of neutralization by antibodies, selection of escape mutants and studies of viral entry.
— Cyanobacterial strains, including one with the highest productivity of sucrose in cyanobacteria to date. Lin, P. C., Zhang, F., & Pakrasi, H. B. (2020). Enhanced production of sucrose in the fast-growing cyanobacterium Synechococcus elongatus UTEX 2973. Scientific reports, 10(1), 1-8.
— Gastrin-releasing peptide (GRP) functions as neurotransmitter for non-histaminergic itch. This mouse line has the Cre gene knocked into Grp locus and could be used for studies of GRP function in different tissues. Barry, D. M., Liu, X. T., Liu, B., Liu, X. Y., Gao, F., Zeng, X., … & Tao, A. …
— Panel of 300 recombinant human monoclonal antibodies that are directed against influenza virus HA. These antibodies were derived from plasmablasts and germinal center B cells that were isolated from three healthy volunteers after influenza vaccination. Turner, J. S., Zhou, J. Q., Han, J., Schmitz, …
— AN1.1 is an iPSC line that was reprogrammed from healthy renal epithelial cells. Has proven easy to use for gene editing and efficient for differentiating into a number cell/tissue types. Whole genome sequencing data is available.
— Mayaro virus (MAYV) is an emerging mosquito-transmitted alphavirus. This is a panel of 18 neutralizing mAbs agains MAYV, 11 of which have activity that inhibited infection with EC50 values
— These plasmids can be used for single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution (WUSTL Technology T-018069). scCC simultaneously maps the precise location of tran…
