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Mouse monoclonal antibodies against SARS-CoV-2 nucleocapsid proteinEllebedy, Ali
T-019510
— These are six monoclonal antibodies specific to SARS-CoV-2 Nucleocapsid protein that could potentially be used for COVID-19 diagnostics.
Transcription factor EB (TFEB) materialsDiwan, Abhinav
T-019513
— Materials that have been used to study transcription factor EB (TFEB), a lysosomal biogenesis factor:
Plasmid library for miRNA, Pumilio, Smaug and AU-rich elementsDjuranovic, Sergej
T-019514
— This is the pcDNA-5 plasmid library with 6500 barcoded constructs containing eGFP followed by 650 combinations of 3’UTRs with miRNA, Pumilio, Smaug and AU-rich. This library can be used to optimize gene expression and to study gene regulation by different micro RNAs and RNA-binding proteins. …
Leishmania guyanensis with mCherry and luciferaseBeverley, Stephen
T-019515
— Leishmania guyanensis strain M4147 (+/- LRV) engineered to express two markers, mCherry and firefly luciferase. The constructs are stably integrated into the ribosomal RNA SSU locus. Parasites with these markers can be followed by fluorescence or bioluminescence approaches which is faster and requir…
VSV-BSL2 reporter of SARS CoV infectionBloyet, Louis-Marie ; Whelan, Sean
T-019518
— This VSV-SARS1 chimeric virus is a biosafety level 2 reporter of SARS COV 1 infection. It could be used to study shared mechanisms of neutralization by antibodies, selection of escape mutants and studies of viral entry.
Cyanobacteria engineered for enhanced sucrose productionPakrasi, Himadri
T-019524
— Cyanobacterial strains, including one with the highest productivity of sucrose in cyanobacteria to date. Lin, P. C., Zhang, F., & Pakrasi, H. B. (2020). Enhanced production of sucrose in the fast-growing cyanobacterium Synechococcus elongatus UTEX 2973. Scientific reports, 10(1), 1-8.
Grp-iCre miceChen, Zhou-Feng
T-019525
— Gastrin-releasing peptide (GRP) functions as neurotransmitter for non-histaminergic itch. This mouse line has the Cre gene knocked into Grp locus and could be used for studies of GRP function in different tissues. Barry, D. M., Liu, X. T., Liu, B., Liu, X. Y., Gao, F., Zeng, X., … & Tao, A. …
Anti-Influenza HA monoclonal antibodiesEllebedy, Ali
T-019529
— Panel of 300 recombinant human monoclonal antibodies that are directed against influenza virus HA. These antibodies were derived from plasmablasts and germinal center B cells that were isolated from three healthy volunteers after influenza vaccination. Turner, J. S., Zhou, J. Q., Han, J., Schmitz, …
iPSC line AN1.1Neilson, Amber
T-019532
— AN1.1 is an iPSC line that was reprogrammed from healthy renal epithelial cells. Has proven easy to use for gene editing and efficient for differentiating into a number cell/tissue types. Whole genome sequencing data is available.
Mayaro virus monoclonal antibodies and hybridomasEarnest, James ; Diamond, Michael
T-019543
— Mayaro virus (MAYV) is an emerging mosquito-transmitted alphavirus. This is a panel of 18 neutralizing mAbs agains MAYV, 11 of which have activity that inhibited infection with EC50 values
Plasmids for calling cards and single cell calling cardsMoudgil, Arnav ; Wilkinson, Michael Nathaniel ; Lalli, Matthew ; Chen, Xuhua ; Mitra, Robi
T-019487
— These plasmids can be used for single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution (WUSTL Technology T-018069). scCC simultaneously maps the precise location of tran…
Inflammatory bowel disease biomarkers and therapeutic targetLiu, Ta-Chiang ; Kaiko, Gerard ; Stappenbeck, Thaddeus
T-017071
— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…
Automated image processing tools for quantitative SPECT and PET scansYu, Zitong ; Moon, Hae Sol ; Rahman, Md Ashequr ; Liu, Ziping ; Jha, Abhinav Kumar
T-019331
— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…
Low cost, versatile enzymatic synthesis of beta-lactone peptides for antibiotic or serine hydrolase inhibitor drug discoverySchaffer, Jason ; Reck, Margaret ; Wencewicz, Timothy
T-016508
— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…
Rapid, accurate RT-PCR test for enterovirus D68Wylie, Todd ; Wylie, Kristine ; Storch, Gregory
T-015155
— Technology Description A team of researchers at Washington University designed patented primers for a sensitive, specific, real-time reverse transcriptase PCR (RT-PCR) assay to quickly detect enterovirus D68 (EV-D68). EV-D68 is an emerging, highly contagious respiratory virus that can cause seve…
Monoclonal antibodies against pSer784-VCPShao, Jieya
T-019491
— VCP is an essential AAA+ ATPase that regulates proteostasis under normal and stressed cellular conditions. These monoclonal antibodies specifically recognize pSer784-VCP, which is phosphorylated during the DNA damage response and plays a crucial role in cellular survival upon genotoxic chemotherapy …
Biological and Biochemical Production of Enantiopure L-Piperazic AcidHu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073
— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…
In vivo editing via targeted adenoviral vectorsCuriel, David
T-016332
— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…
Low-cost optical sensors for high performance, discrete hearing aidsLiao, Jie ; Yang, Lan
T-019167
— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…
Treatment for chronic migrainesZhang, Jintao ; Zhang, Zhiyu ; Hu, Rong ; Cloud, Megan ; Cao, Yu-Qing
T-018942
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…