IgG Monoclonal Antibodies to Enterococcus Faecalis Gelatinase

— Primary Inventor: Phillip I. Tarr, MD

Target: GelE(mAb 8A3)

Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…

Dementia Screening test: the AD8

— The AD8 is an 8 question interview tool which distinguishes individuals with very mild dementia from those without dementia, regardless of etiology. The AD8 is based on intraindividual decline and has been demonstrated to be a valid and reliable screening tool for dementia.

PEGylated-GIRLRG Peptide for Radiopharmaceutical Delivery

— Technology: GRP78 is a chaperone that is part of a complex that controls the maturation of glycoproteins in the ER and senses cellular stress in normal cells. However, following radiation treatment, GRP78 is also expressed on the surface of cancer cells and has anti-apoptotic and pro-angiogenesis ac…

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