by | Mar 10, 2018 | Achilefu, Samuel, Kotagiri, Nalinikanth
— Background: Around 1 million patients receive radiation therapy every year with an estimated cost of $2,000 per treatment. The market demands technologies that can provide efficacious therapeutics and diagnostic imaging while minimizing harmful side effects. Photodynamic therapy can simultaneously s…
by | Mar 10, 2018 | Achilefu, Samuel, Black, Kvar
— This invention is the formulation of a SPECT nanoparticle probe for the detection of MMP activity. The surface of a 10 nm-sized gold nanoparticle is functionalized through a thiol anchor with a peptide that is cleaved in the presence of MMP9. The surface is also functionalized with methoxy polyethyl…
by | Mar 10, 2018 | Lanza, Gregory, Pan, Dipanjan, Senpan, Angana, Wickline, Samuel
— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…
by | Mar 10, 2018 | Connolly, Janet, Fremont, Daved, Hansen, Ted, Lybarger, Lonnie, Miley, Michael, Mitaksov, Vesselin, Truscott, Steven