by | Sep 29, 2021 | Ellebedy, Ali
— Disease indication – SARS-CoV-2 infection (COVID-19)
Drug format
Drug class – Best-in-class
Research stage and Preliminary data – The inventors have developed and characterized these antibodies, creating a chimeric version with a human IgG backbone for SARS2-38. The antibodies have …
by | Sep 17, 2021 | Crowley, Jan, Henderson, Jeffrey P., Robinson, John
— Technology Description
Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …
by | Sep 9, 2021 | Choi, Kyunghee, Kabir, Ashraf Ul, Krchma, Karen
— Technology Description
Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…
by | Sep 6, 2021 | Azab, Abdel Kareem, Azab, Feda, de la Puente Garcia, Maria del Pilar
— Background
External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…
by | Sep 2, 2021 | Schreiber, Robert
— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice.
F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…