by | Dec 1, 2019 | Hawkins, William, Hotchkiss, Richard, Spitzer, Dirk
— WUSTL Technology 007646
Technology Description
Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…
by | Nov 25, 2019 | Henderson, Jeffrey P.
— Technology Description
Researchers in Prof. Jeffrey Henderson’s laboratory have discovered a drug target and a class of small molecule candidates that could be used to selectively prevent pathogenic enterobacteria from causing diseases such as urinary tract infections (UTIs).
Currently, UTI…
by | Nov 18, 2019 | Altman, Michael, Green, Olga, Kavanaugh, James, Li, Hua, Mutic, Sasa, Wooten, Hasani
— Technology Description
A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis.
Currently, automated contouring tools for delineating tu…
by | Nov 6, 2019 | Allen, Paul
— Target: Full length mouse Vb 8.3 TCR but not 8.1 or 8.2. Vb 8.3.
Application: Flow cytometry
This antibody was made by immunizing Armenian hamsters. It was used to study the mechanisms that act to keep only one functional TCR beta-chain per cell and the effect of selecting ligand density on positive selection and endogenous receptor usage in mice.
Publication: TCR transgenic mice in which …
by | Oct 22, 2019 | Clark, Amy, Mahadevan, Jana, Urano, Fumihiko
— Technology Description
Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…