by | Oct 22, 2019 | Bieschke, Jan, Guruswami, Sundaram, Liu, Yongjian, Sharma, Vijay
— Background
8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…
by | Oct 22, 2019 | Urano, Fumihiko
by | Oct 22, 2019 | Ory, Daniel
— Notes: Mouse model with the mutation for NPC knocked in.
by | Jun 7, 2018 | Shaikh, Nurmohammad, Tarr, Phillip
— Primary Inventor: Phillip I. Tarr, MD
Target: GelE(mAb 8A3)
Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…
by | Mar 10, 2018 | Rossin, Raffaella, Welch, Michael, Woodard, Pamela
— Background
Atherosclerosis is a disease process in which lipid deposition causes the formation of plaques that lead to thickening of the artery walls. The cause of a majority of fatal acute myocardial infarction and sudden coronary death is due to the rupture of soft or unstable plaques; however, t…