Mouse monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
— These are six monoclonal antibodies specific to SARS-CoV-2 Nucleocapsid protein that could potentially be used for COVID-19 diagnostics.
In vivo editing via targeted adenoviral vectors
— Background:
Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…
Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
— Technology Description
An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…
IL34 tm1b and tm1c mice
— Mouse line knockouts of IL-34. IL-34 is a growth factor for macrophages, microglia, and Langerhans cells, among others.
Publication: IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
IL33 tm1b and tm1c
— The Colonna lab generated two IL-33 knockout mouse lines – a total and a conditional knockout models. IL-33 is a crucial mediator of inflammation.
Publication: IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation
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