by | Nov 25, 2019 | Henderson, Jeffrey P.
— Technology Description
Researchers in Prof. Jeffrey Henderson’s laboratory have discovered a drug target and a class of small molecule candidates that could be used to selectively prevent pathogenic enterobacteria from causing diseases such as urinary tract infections (UTIs).
Currently, UTI…
by | Nov 20, 2019 | Burgess, Robert, Sanes, Joshua
— This mouse strain has loxP sites flanking exons 3 and 4 of the ChAT gene. There is a Neo gene in the intron between exons 4 and 5. Mating these mice to A-Cre mice generates a null allele in subsequent generations, in which no ChAT protein or activity is detectable. The mice are maintained in the C57…
by | Nov 20, 2019 | Sanes, Joshua
— Myl-CFP Mice
The coding sequence for the enhanced CFP was inserted downstream of ~5kb of putative regulatory sequences from the mouse myosin Type I heavy chain gene. Transgenic mice were generated by pronuclear injection using standard methods.
JAX Stock No. 06922
MyIIA-RFP Mice
A ~100kb genomic…
by | Nov 20, 2019 | Schreiber, Robert
— Target: C-X-C chemokine family member (CXCR3). Expressed on NK cells, activated T lymphocytes, select
endothelial and epithelial cells.
Hamsters were immunized with a multiple antigens peptide-8 (MAPS-8) encompassing amino acids 1 to 37 of mouse CXCR3 in complete Freund’s adjuvant, and boosted with peptide in incomplete Freund’s adjuvant. Hamsters showing ELISA seropositivity for CXCR3 peptide were boosted and hybridomas gen…
by | Nov 13, 2019 | Listenberger, Laura, Ory, Daniel, Schaffer, Jean
— Gadd7 haploinsufficient mutant CHO cell line
Inventors generated a mutant Chinese Hamster Ovary (CHO) cell line with disruption of one allele encoding Gadd7, a non-coding RNA. CHO cells were transduced with retrovirus at a low multiplicity of infection and mutants were isolated. Number of retrovira…