Devices Summaries

Ultra-Rare Variant Detection using Next Generation Sequencing
Druley, Todd ; Young, Andrew
T-014312

— Next Generation Sequencing (NGS) allows rapid sequencing of an individual’s entire genome or portions of the genome to identify thousands of genetic variants. Personalized genomic tests based on NGS technologies can be used to predict an individual’s risk of disease or monitor disease pr…

Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in Infants
Knoop, Kathryn ; McDonald, Keely ; Newberry, Rodney
T-016480

— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…

Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
Maslov, Konstantin ; Rao, Bin ; Song, Liang ; Wang, Lihong
T-010922

— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…

Dynamic seal valve to prevent aerosol infection
Cashin, John ; Hartquist, Chase ; Lowe, Halle ; Zayed, Mohamed
T-019628

— Technology Description Researchers in Mohamed Zayed’s lab at Washington University have developed a dynamic seal valve that creates a seal around devices with varying cross sections. This valve could be deployed in masks to protect health care workers from aerosol infection while using airwa…

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…

Controlling charge doping in 2D materials
Balgley, Jesse ; Henriksen, Erik
T-019602

— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

Lightweight, wearable cap for bedside functional optical neuroimaging
Bergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611

— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …

Barbed mesh for fast, suture-less surgical wound closure
Felder, John
T-018828

— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…

Low-cost optical sensors for high performance, discrete hearing aids
Liao, Jie ; Yang, Lan
T-019167

— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…

Adhesive coated sutures for stronger musculoskeletal repairs
Genin, Guy ; Linderman, Stephen ; Thomopoulos, Stavros
T-014989

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed patented adhesive-coated sutures with the potential to reduce ruptures following surgical repair of tendons and ligaments. These modified sutures are designed to minimize stress by shifting the mec…

Stent System for the Treatment of Aorto-Iliac Occlusive Disease
Wirtz, Alexander ; Zayed, Mohamed
T-018558

— Technology Description Researchers at Washington University in St. Louis developed an improved stent system to treat aorto-iliac occlusive disease. Aorto-iliac occlusive disease is caused by atherosclerotic plaque accumulation in the abdominal aorta where it connects to the common iliac arteries. …

Arteriovenous graft designed to prevent thrombosis and graft failure
Genin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994

— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

Improved NMR sensitivity with an integrated EPR-NMR spectrometer
Barnes, Alexander
T-014431

— Technology Description Researchers in Dr. Alexander Barnes’s lab at Washington University have developed a low-noise integrated EPR-NMR spectrometer with improved NMR sensitivity and faster acquisition times. This patented device can increase sensitivity in NMR experiments (potentially by a …

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…

Toolkit to efficiently design exact pulse code sequences for MRI, NMR or quantum computing
Li, Jr-Shin
T-017456

— Technology Description Engineers in Prof. Jr-Shin Li’s laboratory have developed a computationally efficient analytical technique to design exact RF pulse code sequences which optimize quantum applications such as MRI for medical diagnosis, NMR spectroscopy for uncovering protein structures …

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

Steerable Thermoablation Probe for Improved Access to Brain Lesions
Leuthardt, Eric
T-015768

— Technology Description An interdisciplinary team led by Professor Eric Leuthardt has developed a steerable device that can be integrated into existing thermoablation systems to treat abnormal brain lesions. Thermoablation is a more targeted and less disruptive method for treating lesions than chem…

Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers
Grigsby, Perry
T-012905

— Technology Description Researchers in Dr. Perry Grigsby’s lab have developed a patented brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers. Gynecological cancers, such as recurrent endometrial and cervical cancers, can be treated with brachytherapy, but requir…

Applicator device for reducing artifacts in MR-guided gynecological brachytherapy
Grigsby, Perry ; Zoberi, Jacqueline
T-011297

— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…

Insert device that enhances MR and PET image resolution for MR-PET machines
Tai, Yuan-Chuan
T-007555

— Background PET-CT scanners have been widely used in the identification of tumors and localization for biopsies due to its superior ability to detect biochemical and physiological functions. However, one of the main limitations of PET-CT is the inability to visualize soft tissues, which may be impor…

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Optical Resolution Photoacoustic Imaging Device for Port-Wine Stains
Maslov, Konstantin ; Rao, Bin ; Wang, Lihong
T-012585

— A photoacoustic tomography device that provides high optical absorption contrast with high lateral resolution, including very good melanin distribution images, for port wine stain birthmarks.

Planar storage phosphor dosimeter for radiation therapy dosimetry
Li, Hui
T-009252

— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…

Myocardial perfusion SPECT optimization
Jha, Abhinav Kumar ; Rahman, Md Ashequr ; Siegel, Barry ; Yu, Zitong
T-020357

— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…

Passive and Compact Liquid Metal Heat Switch
Weisensee, Patricia
T-019180

— Technology Description Researchers in Patricia Weisensee’s lab at Washington University have developed a compact liquid metal heat switch with a passive mechanism to control the thermal management system of spacecraft. Unlike other switch mechanisms, the liquid metal version produces high co…

Atrial fibrillation treatment with patient-specific model to design ablation lesions
Damiano, Ralph ; Schuessler, Richard
T-005819

— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…

Novel Method and Device to Produce Fluorine-18 PET Tracers
Zhou, Dong
T-019276

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Low-cost, synthetic hydrogel scaffold to promote nerve growth and regeneration
Elbert, Donald ; Roam, Jacob
T-016599

— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

High Throughput Acoustic Particle Separation
Berezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364

— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…

Low-cost optical sensors for high performance, discrete hearing aids
Liao, Jie ; Yang, Lan
T-019167

Adhesive coated sutures for stronger musculoskeletal repairs
Genin, Guy ; Linderman, Stephen ; Thomopoulos, Stavros
T-014989

Stent System for the Treatment of Aorto-Iliac Occlusive Disease
Wirtz, Alexander ; Zayed, Mohamed
T-018558

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Steerable Thermoablation Probe for Improved Access to Brain Lesions
Leuthardt, Eric
T-015768

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Schwartz, Alan ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers
Grigsby, Perry
T-012905

Applicator device for reducing artifacts in MR-guided gynecological brachytherapy
Grigsby, Perry ; Zoberi, Jacqueline
T-011297

Optimized Non-Coplanar Radiation Delivery for Simpler, Faster, and Safer Treatments
Mutic, Sasa ; Zhang, Tiezhi
T-016307

— Existing LINACs inefficiently deliver non-coplanar beams The goal of radiation treatment is to precisely deliver a prescribed radiation dose to the targeted tissue, while avoiding dosing the surrounding normal tissues and organs. These treatments require radiation beams to be delivered from multipl…

Barbed mesh for fast, suture-less surgical wound closure
Felder, John
T-018828

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

Device for diabetes cell replacement therapy
Millman, Jeffrey ; Song, Jiwon
T-016681

— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…

Arteriovenous graft designed to prevent thrombosis and graft failure
Genin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

Lightweight, wearable cap for bedside functional optical neuroimaging
Bergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611

Robust, scalable phase control system for non-invasive neuromodulation devices
Li, Jr-Shin ; Zlotnik, Anatoly
T-016206

— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

WASHU INNOVATION CATALOG

Devices Summaries

Office of Technology Management