Probes Summaries
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015124
— Technology Description A team of researchers at Washington University developed “ViroCap”, a patented capture probe technique for senistive, comprehensive, in-depth metagenomics analysis vertebrate viruses. This invention could enhance traditional metagenomics shotgun sequencing (MSS) w…
PEGylated-GIRLRG Peptide for Radiopharmaceutical DeliveryHallahan, Dennis
T-014562
— Technology: GRP78 is a chaperone that is part of a complex that controls the maturation of glycoproteins in the ER and senses cellular stress in normal cells. However, following radiation treatment, GRP78 is also expressed on the surface of cancer cells and has anti-apoptotic and pro-angiogenesis ac…
Armenian Hamster Anti-Mouse Tapasin Antibody, clone 5D3Hansen, Ted ; Lybarger, Lonnie ; Wang, Xiaoli
T-016628
— Target: Amino acids 11-34 of mouse tapasin. Application(s): Western Blotting Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…
Simple, universal DNA motifs for modulating protein productionDjuranovic, Sergej
T-016819
— Technology Description Researchers in Prof. Sergej Djuranovic’s laboratory have discovered short DNA coding motifs that can increase or decrease expression of recombinant proteins by 3-4 orders of magnitude in a variety of organisms. Together, these universal tools can provide tightly contro…
Novel Method and Device to Produce Fluorine-18 PET TracersChu, Wenhua ; Zhou, Dong
T-015970
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …
IgG Monoclonal Antibodies to Enterococcus Faecalis GelatinaseShaikh, Nurmohammad ; Tarr, Phillip
T-011748
— Primary Inventor: Phillip I. Tarr, MD Target: GelE(mAb 8A3)Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…
Novel PET/SPECT Radiopharmaceutical for Improving Biomedical ImagingPiwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438
— Technology Description Researchers at Washington University in St. Louis have developed a novel positron emission tomography (PET) radiopharmaceutical for myocardial perfusion imaging. Myocardial perfusion scintigraphy is widely employed in the evaluation of patients with heart disease. Several ag…
Novel Method and Device to Produce Fluorine-18 PET TracersChu, Wenhua ; Zhou, Dong
T-015970
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …
Sigma-1 targeted PET tracersMach, Robert ; Tu, Zhude "Will" ; Wang, Wei
T-010394
— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…
S1P1-targeted PET tracersLiu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151
— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…
SPECT imaging nanoprobe for the detection of matrix metalloproteinase (MMP) activityAchilefu, Samuel ; Black, Kvar
T-014635
— This invention is the formulation of a SPECT nanoparticle probe for the detection of MMP activity. The surface of a 10 nm-sized gold nanoparticle is functionalized through a thiol anchor with a peptide that is cleaved in the presence of MMP9. The surface is also functionalized with methoxy polyethyl…
Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive functionJin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517
— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…
MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluationBaldelomar, Edwin ; Bennett, Kevin
T-019017
— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…
Novel Method and Device to Produce Fluorine-18 PET TracersZhou, Dong
T-019276
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …
Novel Method and Device to Produce Fluorine-18 PET TracersZhou, Dong
T-019276
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …
