Medical-Clinical Applications Summaries

Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral Content
Smith, Lester ; Thomopoulos, Stavros
T-013230

— Background: Tissue engineered scaffold repair materials are currently modified with surface mineralization with simulated body fluids (SBF) of collagen provide a lower stiffness than desired in biosynthetic entheses and fail to replicate the naturally graded structure of the human connective tissue …

Robust, scalable phase control system for non-invasive neuromodulation devices
Li, Jr-Shin ; Zlotnik, Anatoly
T-016206

— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…

Zuum – app
Colditz, Graham ; Corcoran, Heather
T-011983

— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Optimized Non-Coplanar Radiation Delivery for Simpler, Faster, and Safer Treatments
Mutic, Sasa ; Zhang, Tiezhi
T-016307

— Existing LINACs inefficiently deliver non-coplanar beams The goal of radiation treatment is to precisely deliver a prescribed radiation dose to the targeted tissue, while avoiding dosing the surrounding normal tissues and organs. These treatments require radiation beams to be delivered from multipl…

Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral Content
Smith, Lester ; Thomopoulos, Stavros
T-013230

Photothermal disinfection of N95 respirators
Jun, Young-Shin ; Singamaneni, Srikanth
T-019477

— Technology Description A team of researchers led by Young-Shin Jun have developed a polymer coating for N95 respirators that would permit fast, easy, and cheap N95 disinfection using only direct sunlight. The researchers coated the outermost fabric layer in polydopamine, which converts photon energ…

Barbed mesh for fast, suture-less surgical wound closure
Felder, John
T-018828

— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…

Pressure recovery ratio (PRR) index for real-time assessment of heart failure
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid ; Zhang, Weixiong
T-007562

— Technology Description Researchers in the Cardiovascular Biophysics Laboratory at Washington University developed a patented, real-time, automated index to reliably detect delayed relaxation during cardiac catheterization diagnostics. This technique, called pressure recovery ratio (PRR), serves as…

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Hydrogels for localized radiotherapy
Azab, Abdel Kareem ; Azab, Feda ; de la Puente Garcia, Maria del Pilar
T-013626

— Background External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Algorithm for Multi-Agent Coordination Through Adaptively Regularized Parallel Distributed Optimization
Gilboa, Elad
T-012524

— Many problems require the analysis of large, high-dimensional datasets, which make the problem intractable to most optimization algorithms. Gilboa has developed a new parallel distributed algorithm for block optimization problems using adaptive regularizer PDARÂ. PDAR is able to solve both t…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

Novel Acute Myocardial Injury Biomarker Profile
Bach, Richard ; Boyle, Walter
T-015345

— Background: Cardiovascular disease, including acute myocardial injury (AMI), is responsible for over 610,000 deaths per year in the US making it the number one cause of death. The gold standard for AMI diagnosis relies on determination of the cardiac troponin I (cTnI) plasma level. The rise in the l…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

Quit Helpers
Colditz, Graham ; McQueen, Amy ; Sumner, Walton
T-014916

— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…

Patient Access Scheduling System
Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill ; Melnek, Christine ; Reynolds, Steven ; Whipple, Toni
T-015846

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

Parallel single step prediction algorithm for conductivity-tensor estimation
Gilboa, Elad ; La Rosa Araya, Patricio ; Nehorai, Arye
T-011907

— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…

Copy number Aberration Driven Endocrine Response (CADER) gene signature
Ellis, Matthew ; Luo, Jingqin
T-011920

— Identifying patients at risk of relapse while undergoing particular treatment protocols is critically important yet challenging to do in a timely manner. Researchers at Washington University have deveoped a new method to rapidly and accurately determine relapse risk in a human subject afflicted with…

Intraoperative Mapping Tool for Identifying Functional Brain Areas in Anesthetized Patients
Breshears, Jonathan ; Leuthardt, Eric
T-010379

— Value Proposition: New technique for examining active brain areas in unconscious neurosurgical patients. Technology Description Researchers at Washington University in St. Louis have developed a new process that includes a new use for existing electrocorticographic (ECoG) grids, an amplifier, an…

Dynamic seal valve to prevent aerosol infection
Cashin, John ; Hartquist, Chase ; Lowe, Halle ; Zayed, Mohamed
T-019628

— Technology Description Researchers in Mohamed Zayed’s lab at Washington University have developed a dynamic seal valve that creates a seal around devices with varying cross sections. This valve could be deployed in masks to protect health care workers from aerosol infection while using airwa…

Small molecules targeting KCNQ in ventricular arrhythmia
Cui, Jianmin
T-013554

— Disease indication – Long QT Syndrome (resulting in ventricular arrhythmia, epilepsy, deafness) Drug format – Small molecule Drug class – Lead compounds are repurposed drugs Research stage and preliminary data – Based on in silico screening of KCNQ, the researchers selecte…

Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral Content
Smith, Lester ; Thomopoulos, Stavros
T-013230

Robust, scalable phase control system for non-invasive neuromodulation devices
Li, Jr-Shin ; Zlotnik, Anatoly
T-016206

MRI-based virtual histopathology for non-invasive diagnosis of prostate cancer, glioblastoma and other conditions
Song, Sheng-Kwei "Victor" ; Ye, Zezhong
T-016528

— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

Hydrogels for localized radiotherapy
Azab, Abdel Kareem ; Azab, Feda ; de la Puente Garcia, Maria del Pilar
T-013626

Algorithm and alert process for the prediction and prevention in-patient Treatment-related severe hypoglycemia
Tobin, Garry
T-012472

— Technology Description: A hospital-based algorithm and associated software that is able to predict which in-patients on diabetic therapy will develop hypoglycemia. It is able to predict in real time which patients are at risk and alert MDs to start interventions to prevent possible side effects or d…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

Ultra-Rare Variant Detection using Next Generation Sequencing
Druley, Todd ; Young, Andrew
T-014312

— Next Generation Sequencing (NGS) allows rapid sequencing of an individual’s entire genome or portions of the genome to identify thousands of genetic variants. Personalized genomic tests based on NGS technologies can be used to predict an individual’s risk of disease or monitor disease pr…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

Novel Acute Myocardial Injury Biomarker Profile
Bach, Richard ; Boyle, Walter
T-015345

Itaconate Immunomodulatory Properties-Ischemia Reperfusion
Artyomov, Maxim ; Lampropoulou, Vasiliki "Vicky"
T-016181

— Technology Summary: Approximately 1.3 million individuals each year in USA alone are affected by ischemia-reperfusion injuries. A substantial portion of such injuries is the result of macrophage-mediated inflammation. There are some conventional methods for treating macrophage-mediated inflammation,…

VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

Zuum – app
Colditz, Graham ; Corcoran, Heather
T-011983

— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

Copy number Aberration Driven Endocrine Response (CADER) gene signature
Ellis, Matthew ; Luo, Jingqin
T-011920

Method To Remove Brain Stimulation Artifacts in Neural Signals
Brunner, Peter ; Leuthardt, Eric ; Willie, Jon ; Xie, Tao
T-020083

— Value proposition: Method and system for removing multiple types of brain stimulation artifacts in neural signals to improve neurological diagnoses and therapies. Technology Description Researchers at Washington University in St. Louis have developed a method to remove brain stimulation artifact…

Small molecules targeting KCNQ in ventricular arrhythmia
Cui, Jianmin
T-013554

Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral Content
Smith, Lester ; Thomopoulos, Stavros
T-013230

Software to predict low back pain from brain imaging
Hawasli, Ammar ; Jayasekera, Dinal ; Lamichhane, Bidhan ; Leuthardt, Eric ; Ray, Wilson
T-019322

— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…

Machine learning methods for real-time MRI image processing: MRI-only radiation treatment planning and improving MR image resolution
Green, Olga ; Mutic, Sasa ; Park, Chunjoo (Justin) ; Zhang, Hao
T-018522

— Technology Description A team of researchers at Washington University School of Medicine developed deep learning image processing techniques to improve MRI diagnostics and potentially enable faster, more precise MRI-guided radiation therapy without exposing patients to radiation from CT imaging. S…

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Toolkit to efficiently design exact pulse code sequences for MRI, NMR or quantum computing
Li, Jr-Shin
T-017456

— Technology Description Engineers in Prof. Jr-Shin Li’s laboratory have developed a computationally efficient analytical technique to design exact RF pulse code sequences which optimize quantum applications such as MRI for medical diagnosis, NMR spectroscopy for uncovering protein structures …

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Selective RANK ligand to treat osteoporosis
Fremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

Accurate, efficient 2D strain mapping with robust detection of strain localization
Boyle, John ; Genin, Guy ; Pless, Robert ; Thomopoulos, Stavros
T-014090

— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Self-powered, solid-state devices for remote sensing, timing and security of internet-of-things and other passive assets
Chakrabartty, Shantanu ; Zhou, Liang
T-015908

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a self-powered, CMOS-based, nano-scale “smart sensor” and timer system that uses quantum-tunneling for reliable, long-lasting memory or authentication. This technology is a floating gate …

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

In vivo editing via targeted adenoviral vectors
Curiel, David
T-016332

— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…