Nephrology-Renal Summaries

Kidney Disease Biomarkers for Diagnosis, Prognosis or Clinical Trials Monitoring
Chen, Ying ; Kim, Yeawon
T-016375

— Published date: 5/29/2026 Value Proposition: Urine-based biomarkers that can be used for early detection and diagnosis of kidney disease non-invasively. Technology Description Researchers at Washington University in St. Louis have identified three sensitive, urine-based biomarkers of kidney di…

Techniques to Measure Nephron Number in the Kidney In Vivo
Baldelomar, Edwin ; Bennett, Kevin
T-021632

— Published date: 5/23/2026 Value Proposition: Method that uses non-contrast MRI to measure nephron number for individualized assessment of kidney functional capacity. Technology Description Researchers at Washington University in St. Louis have developed a method of using non-contrast MRI to d…

Bedside Noninvasive Imaging Test to Assess Kidney Function
Baldelomar, Edwin ; Bennett, Kevin
T-021392

— Published date: 4/18/2026 Value Proposition: Method that uses ultrasound to detect functional nephron number in the kidneys. Technology Description Current clinical markers of kidney health (serum creatinine and estimated glomerular filtration rate (eGFR)) are insensitive to the early progressi…

Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injury
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack ; Laterza, Omar ; Lockwood, Christina ; Modur, Vijay
T-013292

— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…

Arteriovenous graft designed to prevent thrombosis and graft failure
Genin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994

— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …

miRNA mimics to treat metabolic disease
Gong, Yong-feng ; Hou, Jianghui
T-017930

— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…

MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluation
Baldelomar, Edwin ; Bennett, Kevin
T-019017

— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…