Summaries by Inventor Chen, Zhou-Feng

Grp-iCre mice
Chen, Zhou-Feng
T-019525

— Gastrin-releasing peptide (GRP) functions as neurotransmitter for non-histaminergic itch. This mouse line has the Cre gene knocked into Grp locus and could be used for studies of GRP function in different tissues. Barry, D. M., Liu, X. T., Liu, B., Liu, X. Y., Gao, F., Zeng, X., … & Tao, A. …

Grp Floxed mouse strain
Chen, Zhou-Feng
T-019157

— Grp floxed mouse strain These mice have loxP sites flanking exon 1 of the Grp gene. It was used to study the mechanism of itch and further interrogation of itch-nerve fibers in the skin under chronic pruritus. Publication: Exploration of Sensory and Spinal Neurons Expressing GRP in Itch and Pain …

Grpr Flox Mouse Strain
Chen, Zhou-Feng
T-019158

— Grpr floxed mouse strain This mouse strain has loxP sites flanking exon 2 of the Grpr gene. Inventors backcrossed the mice into the C57Bl/6J background. The mouse strain was used to study contagious itch and demonstrated that GRP-GRPR signaling is necessary and sufficient for transmitting contagiou…

Treatment for Centrally Mediated Itching
Chen, Zhou-Feng ; Sun, Yan Gang
T-006757

— Background: Severe itch (or pruritus) is associated with multiple diseases such as liver disease, non-Hodgkin’s lymphoma, psoriasis, and common eczema and is also a side effect of many treatments including analgesics (like morphine) and renal dialysis. Chronic pruritus is a top reason for derm…

MOR1D Mediates Opioid and Liver Disease-Induced Itch via GRPR
Chen, Zhou-Feng ; Liu, Xianyu
T-011473

— Background: Opioids, such as morphine, are used in pain management and have significant analgesic effects. However a common side effect of morphine is severe itching. Currently, morphine-induced itch is treated with antagonists against the mu opioid receptor. While these antagonists reduce itch, the…