Summaries by Inventor Dantas, Gautam

Genetically Engineered Yeast Strain for the Treatment of Gastrointestinal Tumors with Immune Checkpoint Inhibitor Therapy
Dantas, Gautam ; Gorushi, Olivia ; Helmink, Beth ; Kwak, Suryang ; Prusa, Jerome ; Wallace, Miranda
T-020850

— Published date: 1/9/2025 Value Proposition: Genetically engineered yeast used to treat gastrointestinal tumors through the delivery of immune checkpoint inhibitor (ICI) proteins. Technology Description Researchers at Washington University in St. Louis have developed a genetically engineered …

New Composition of Matter that can be used to Treat Multidrug Resistant Infections
Dantas, Gautam ; Li, Ruihao ; Wencewicz, Timothy ; Xue, Yao-Peng
T-021458

— Published date: 5/23/2026 Value Proposition: Covalent mechanism-based inhibitors of tetracycline destructases for treating infectious diseases. Technology Description Researchers at Washington University in St. Louis have developed a group of C9-modified anhydrotetracyclines that inhibit tetra…

Small molecule inhibitors to prevent tetracycline resistance
Dantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593

— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…

Novel Combination Therapy that Improves Resistance to Tetracycline Antibiotics
Blake, Kevin ; Dantas, Gautam ; DeAngelo, Caitlin ; Wencewicz, Timothy ; Williford, Emily
T-020451

— Published Date: 1/4/2025 Value Proposition: New composition of matter that combines tetracycline class compounds with destructase inhibitors to overcome resistance to tetracycline antibiotics. Technology Description Researchers at Washington University in St. Louis have developed an enzymatic…