Summaries by Inventor Gilfillan, Susan

CD226 (DNAM1) knockout mice
Colonna, Marco ; Gilfillan, Susan
T-019563

— This is a mouse knockout strain for CD26, also known as DNAM-1 (DNAX accessory molecule 1). DNAM-1 is an adhesion molecule belonging to the immunoglobulin superfamily. This mouse model was used to study the role of DNAM-1 on CD8 T cell and NK cell function in vitro and in vivo. Publication: Gilfill…

IL34 tm1b and tm1c mice
Colonna, Marco ; Gilfillan, Susan ; Wang, Yaming
T-019313

— Mouse line knockouts of IL-34. IL-34 is a growth factor for macrophages, microglia, and Langerhans cells, among others. Publication: IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

IL33 tm1b and tm1c
Colonna, Marco ; Gilfillan, Susan ; Yoshita, Satoru
T-019314

— The Colonna lab generated two IL-33 knockout mouse lines – a total and a conditional knockout models. IL-33 is a crucial mediator of inflammation. Publication: IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation

IL-33 mCherry Mice
Colonna, Marco ; Gilfillan, Susan ; Joshita, Satoru
T-019315

— Reporter mouse line that allows for identification of cells productive IL-33 through mCherry expression. IL-33 is a molecule involved in immune system responses to helminths, allergies, and asthma. Publications:

Mouse and Human Anti-MR1 Hybridoma
Cella, Marina ; Colonna, Marco ; Fremont, Daved ; Gilfillan, Susan ; Hansen, Ted ; Myers, Nancy
T-013681

— Target: Major Histocompatibility Complex, Class 1-Related Protein Notes: Clone available is 26.5Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells. Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells