Summaries by Inventor Rogers, Buck

New PARP-1 Inhibitors for Imaging PARP-1 Expression in Vivo
Chu, Wenhua ; Rogers, Buck ; Xu, Jinbin ; Zhou, Dong
T-018730

— [18F]WC-DZ-F is a derivative of [18F]FluorThanatrace and a radiotherapeutic agent. [18F]WC-DZ-F has suitable biodistribution profile, favourable logP and super metabolic stability in vivo. We have demonstrated that [18F]WC-DZ-F is capable of imaging PARP-1 expression in PC-3 prostate cancer xenograf…