Summaries by Inventor Stappenbeck, Thaddeus
Jain, Umang ; Stappenbeck, Thaddeus
T-019293
— Technology Description: Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…
Inflammatory bowel disease biomarkers and therapeutic targetKaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071
— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…
Intestinal biomarker predicts response to treatment for inflammatory bowel diseaseStappenbeck, Thaddeus ; VanDussen, Kelli
T-019186
— Technology Description Researchers in the Stappenbeck lab have discovered an objective histologic biomarker on intestinal cells that can predict a patient’s response to ustekinumab treatment for Crohn’s disease or ulcerative colitis. Specifically, the length of microvilli (MV) could pr…
Fibroblast-Derived Cell Line Producing Wnt3a, R-spondin 3, & NogginMiyoshi, Hiroyuki ; Stappenbeck, Thaddeus
T-014239
— Tangible Tool: Growth factor over-expressing cell line. Notes: Produces conditioned media to grow various mammalian tissue stem cells.These supportive L-WRN cells can produce conditioned media containing Wnt3a, R-spondin, and Noggin for the the support of gastrointestinal stem cells. This system can be used to make stem cell enriched epithelial spheroids from the mouse gastrointestine. Publication: In vitro expansion and genetic…
Novel Murine AstrovirusesLoh, Joy ; Stappenbeck, Thaddeus ; Thackray, Larissa ; Virgin, Herbert ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan
T-012077
— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…
