Summaries by Inventor Tu, Zhude
Klein, Robyn ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-018580
— Technology Description Researchers at Washington University in St. Louis and colleagues have developed S1PR2-targeted PET tracers. Sphingosine-1-phosphate (S1P) is an important bioactive lipid that regulates critical biological functions by acting through five specific G protein-coupled S1P recept…
F-18 radiotracer for alpha-synucleinTu, Zhude "Will"
T-018513
— These materials are an alpha-synuclein binding compound (standard), and the precursor for PET radiolabeling the compound. Precursor’s code name: TZ61-23; chemical name: 2-((6-methoxypyridin-3-yl)amino)quinolin-6-ol. Standard’s code name: TZ61-44; chemical name: 6-(2-fluoroexthoxy)-N-(6-metho…
Sigma-1 targeted PET tracersMach, Robert ; Tu, Zhude "Will" ; Wang, Wei
T-010394
— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…
S1P1-targeted PET tracersLiu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151
— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…
TZ4877 and 18F-radiolabeling precursor TZ50153Tu, Zhude "Will"
T-017602
— TZ4877 is a ligand for the sphingosine-1-phosphate (S1P) receptor 1 in the CNS, developed and radiolabeled with fluorine-18. TZ4877 is the standard (non-radioactive compound) which is used for HPLC analysis of the S1P1 PET tracer, [18F]TZ4877. TZ50153 is the radiolabeling precursor of the PET tracer…
Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disordersDhavale, Dhruva ; Kotzbauer, Paul ; Tu, Zhude "Will" ; Yue, Xuyi
T-018038
— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…
Styryl Heteroaromatic Ring Containing Analogues for Alpha-SynucleinKotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558
— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…
Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive functionJin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517
— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…
Tri-heterocyclic ring compounds as alpha-synuclein ligandsKotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942
— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…
Radiotracers to detect early Parkinson’s diseaseKotzbauer, Paul ; Qiu, Lin ; Tu, Zhude "Will" ; Yu, Yanbo
T-020559
— Radiotracers to detect early Parkinson’s disease Technology Description Researchers at Washington University in St. Louis, led by Dr. Zhude Tu, have developed two imaging agents for α-synuclein (α-syn) aggregation for use to diagnose early Parkinson’s disease, track dise…
Conformationally-flexible benzamide analogs as sigma-2 selective ligandsMach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063
— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …
