Summaries by Inventor Wang, Xiaoli

Mouse anti-MR1 hybridomas, clone 4E3 and 6D1
Hansen, Ted ; Wang, Xiaoli
T-017622

— mAb 4E3 was derived by immunization of β2m-deficient BALB/c mice with a keyhole limpet hemocyanin-conjugated peptide corresponding to mMR1 residues 130–153 (L A M D Y V A H I T K Q A W E A N L H E L Q Y Q). Hybridomas were produced by standard methods and screened by anti-peptide ELISA. …

Armenian Hamster Anti-Mouse Tapasin Antibody, clone 5D3
Hansen, Ted ; Lybarger, Lonnie ; Wang, Xiaoli
T-016628

— Target: Amino acids 11-34 of mouse tapasin. Application(s): Western Blotting Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…

Targeting B Cells for Antibody-Mediated Graft Rejection
Edelson, Brian ; Fremont, Daved ; Liu, Chang ; Nelson, Christopher ; Wang, Xiaoli
T-018682

— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …