Summaries by Inventor Wencewicz, Timothy

Low cost, versatile enzymatic synthesis of beta-lactone peptides for antibiotic or serine hydrolase inhibitor drug discovery
Reck, Margaret ; Schaffer, Jason ; Wencewicz, Timothy
T-016508

— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…

Clifednamide compounds
Qi, Yunci ; Van Dyke-Blodgett, Joshua ; Wencewicz, Timothy ; Yang, Jinping
T-019321

— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value. Publication: Qi, Y., Ding, E., & Blodget…

Small molecule inhibitors to prevent tetracycline resistance
Dantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593

— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…