Summaries by Inventor Zorumski, Charles

Use of ent-allopregnanolone to treat glaucoma
Covey, Douglas ; Izumi, Yukitoshi ; Zorumski, Charles
T-018940

— Technology Description Researchers from Washington University in St. Louis and colleagues have identified ent-allopregnanolone (ent-AlloP) as a potential therapeutic to treat glaucoma. Glaucoma, the leading cause of irreversible blindness, results from damage to the retinal ganglion cells (RGSs) t…

Novel Sulfated Neurosteroid Molecules for Treating Migraines and Pain
Covey, Douglas ; Evers, Alex ; Mennerick, Steven ; Zorumski, Charles
T-021437

— Published date: 5/23/2026 Value Proposition: Steroidal trifluoromethyl ketone modulators of GABA-A and NMDA receptors for treating migraine, headache, and pain. Technology Description Clinical and scientific experts in modulating GABA-A and NMDA receptors at Washington University in St. Louis…

NMDA receptor modulator for neuroprotection after a stroke
Mennerick, Steven ; Sun, Min-Yu ; Taylor, Amanda ; Zorumski, Charles
T-016328

— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…