Species: Human
Target: SARS-CoV-2 spike protein
Applications:
- Research tool – western blot, flow cytometry, ELISA, neutralization assays
- Diagnostics – antigen detection assay for COVID-19 infection
- Vaccine development
Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below).
Related Web Links: Ellebedy Profile; Ellebedy Lab
mAb name | Ag | 30.0000 | 10.0000 | 3.3333 | 1.1111 | 0.3704 | 0.1235 | 0.0412 | 0.0137 | 0.0046 | 0.0015 | 0.0005 | 0.0002 | µg/mL mAb: |
350.5.3.1A06 | RBD | 2.385 | 2.311 | 2.257 | 2.296 | 2.306 | 1.935 | 1.442 | 0.77 | 0.306 | 0.14 | 0.073 | 0.061 | |
2.363 | 2.175 | 2.123 | 2.095 | 1.982 | 1.875 | 1.419 | 0.768 | 0.328 | 0.152 | 0.078 | 0.058 | |||
Spike | 1.961 | 1.868 | 1.851 | 1.726 | 1.424 | 1.081 | 0.622 | 0.249 | 0.113 | 0.066 | 0.048 | 0.045 | ||
1.955 | 1.916 | 1.781 | 1.697 | 1.431 | 0.939 | 0.561 | 0.632 | 0.328 | 0.143 | 0.08 | 0.055 | |||
BSA | 0.178 | 0.06 | 0.05 | 0.044 | 0.063 | 0.052 | 0.397 | 0.043 | 0.044 | 0.049 | 0.136 | 0.049 | ||
0.071 | 0.266 | 0.044 | 0.042 | 0.05 | 0.06 | 0.071 | 0.044 | 0.045 | 0.047 | 0.044 | 0.046 | |||
350.5.3.1C11 | RBD | 2.012 | 2.052 | 1.993 | 1.846 | 1.88 | 1.67 | 1.112 | 0.587 | 0.241 | 0.115 | 0.067 | 0.058 | |
2.057 | 1.896 | 1.892 | 1.838 | 1.789 | 1.656 | 1.08 | 0.505 | 0.232 | 0.145 | 0.141 | 0.09 | |||
Spike | 1.766 | 1.71 | 1.607 | 1.621 | 1.49 | 1.296 | 0.746 | 0.327 | 0.144 | 0.071 | 0.057 | 0.052 | ||
1.767 | 1.748 | 1.667 | 1.665 | 1.547 | 1.294 | 0.772 | 0.351 | 0.145 | 0.077 | 0.053 | 0.046 | |||
BSA | 0.111 | 0.053 | 0.05 | 0.043 | 0.043 | 0.043 | 0.042 | 0.045 | 0.049 | 0.046 | 0.046 | 0.051 | ||
0.094 | 0.049 | 0.05 | 0.047 | 0.043 | 0.042 | 0.046 | 0.043 | 0.044 | 0.044 | 0.047 | 0.051 | |||
350.5.3.1C08 | RBD | 2.083 | 2.007 | 2.052 | 1.912 | 1.862 | 1.453 | 0.869 | 0.405 | 0.175 | 0.093 | 0.059 | 0.05 | |
1.955 | 1.923 | 1.96 | 1.817 | 1.669 | 1.368 | 0.85 | 0.356 | 0.165 | 0.088 | 0.063 | 0.048 | |||
Spike | 2.089 | 1.986 | 2.073 | 2.053 | 1.853 | 1.616 | 1.074 | 0.486 | 0.206 | 0.109 | 0.067 | 0.052 | ||
2.084 | 2.021 | 1.988 | 1.99 | 1.904 | 1.597 | 1.004 | 0.537 | 0.227 | 0.112 | 0.068 | 0.057 | |||
BSA | 0.062 | 0.05 | 0.042 | 0.043 | 0.042 | 0.044 | 0.055 | 0.042 | 0.047 | 0.04 | 0.041 | 0.047 | ||
0.068 | 0.048 | 0.043 | 0.052 | 0.043 | 0.043 | 0.06 | 0.041 | 0.042 | 0.041 | 0.042 | 0.043 | |||
350.5.3.2A01 | RBD | 1.489 | 1.431 | 1.136 | 0.895 | 0.45 | 0.191 | 0.101 | 0.064 | 0.051 | 0.052 | 0.047 | 0.048 | |
1.533 | 1.286 | 1.002 | 0.707 | 0.373 | 0.178 | 0.09 | 0.059 | 0.056 | 0.049 | 0.047 | 0.047 | |||
Spike | 1.055 | 0.891 | 0.552 | 0.307 | 0.277 | 0.086 | 0.067 | 0.048 | 0.047 | 0.053 | 0.043 | 0.043 | ||
0.979 | 0.719 | 0.556 | 0.352 | 0.176 | 0.09 | 0.068 | 0.05 | 0.061 | 0.049 | 0.044 | 0.043 | |||
BSA | 0.074 | 0.049 | 0.261 | 0.045 | 0.046 | 0.045 | 0.047 | 0.048 | 0.281 | 0.047 | 0.046 | 0.046 | ||
0.073 | 0.051 | 0.049 | 0.047 | 0.051 | 0.045 | 0.043 | 0.044 | 0.045 | 0.046 | 0.046 | 0.045 | |||
350.5.3.2B06 | RBD | 2.167 | 2.126 | 2.115 | 2.069 | 2 | 1.909 | 1.355 | 0.784 | 0.342 | 0.179 | 0.088 | 0.117 | |
2.128 | 2.315 | 2.086 | 1.994 | 1.97 | 1.705 | 1.274 | 0.687 | 0.316 | 0.142 | 0.083 | 0.058 | |||
Spike | 1.942 | 1.987 | 2.261 | 2.272 | 1.796 | 1.632 | 1.238 | 0.67 | 0.331 | 0.154 | 0.094 | 0.06 | ||
2.025 | 2.114 | 1.998 | 1.94 | 1.842 | 1.619 | 1.165 | 0.633 | 0.28 | 0.134 | 0.073 | 0.053 | |||
BSA | 0.105 | 0.08 | 0.057 | 0.333 | 0.047 | 0.047 | 0.045 | 0.044 | 0.047 | 0.045 | 0.044 | 0.054 | ||
0.102 | 0.173 | 0.048 | 0.044 | 0.049 | 0.05 | 0.045 | 0.043 | 0.045 | 0.048 | 0.043 | 0.052 | |||
350.5.3.2C06 | RBD | 2.204 | 2.13 | 2.071 | 1.697 | 1.164 | 0.554 | 0.241 | 0.113 | 0.069 | 0.063 | 0.058 | 0.047 | |
2.07 | 1.989 | 1.915 | 1.579 | 1.027 | 0.526 | 0.3 | 0.107 | 0.066 | 0.061 | 0.05 | 0.047 | |||
Spike | 2.043 | 1.943 | 1.874 | 1.523 | 0.889 | 0.433 | 0.193 | 0.099 | 0.056 | 0.059 | 0.043 | 0.053 | ||
2.076 | 1.968 | 1.85 | 1.583 | 1.032 | 0.454 | 0.2 | 0.115 | 0.07 | 0.055 | 0.05 | 0.05 | |||
BSA | 0.082 | 0.049 | 0.046 | 0.043 | 0.049 | 0.05 | 0.047 | 0.043 | 0.049 | 0.048 | 0.056 | 0.051 | ||
0.092 | 0.048 | 0.047 | 0.042 | 0.041 | 0.041 | 0.061 | 0.041 | 0.043 | 0.042 | 0.042 | 0.042 | |||
350.5.3.2B04 | RBD | 0.182 | 0.085 | 0.061 | 0.052 | 0.049 | 0.046 | 0.047 | 0.048 | 0.045 | 0.046 | 0.044 | 0.047 | |
0.17 | 0.078 | 0.061 | 0.051 | 0.049 | 0.046 | 0.048 | 0.047 | 0.047 | 0.048 | 0.049 | 0.052 | |||
Spike | 0.475 | 0.323 | 0.26 | 0.179 | 0.147 | 0.101 | 0.066 | 0.053 | 0.047 | 0.048 | 0.05 | 0.047 | ||
0.486 | 0.308 | 0.242 | 0.202 | 0.217 | 0.096 | 0.068 | 0.056 | 0.052 | 0.051 | 0.045 | 0.051 | |||
BSA | 0.154 | 0.076 | 0.055 | 0.049 | 0.046 | 0.047 | 0.044 | 0.048 | 0.043 | 0.045 | 0.042 | 0.048 | ||
0.148 | 0.077 | 0.054 | 0.045 | 0.044 | 0.044 | 0.045 | 0.044 | 0.045 | 0.051 | 0.047 | 0.049 | |||
350.5.3.2H08 | RBD | 0.229 | 0.089 | 0.064 | 0.053 | 0.049 | 0.047 | 0.044 | 0.044 | 0.047 | 0.05 | 0.049 | 0.046 | |
0.251 | 0.082 | 0.061 | 0.053 | 0.056 | 0.05 | 0.054 | 0.045 | 0.046 | 0.047 | 0.045 | 0.068 | |||
Spike | 0.384 | 0.302 | 0.224 | 0.18 | 0.134 | 0.081 | 0.059 | 0.052 | 0.047 | 0.048 | 0.049 | 0.052 | ||
0.399 | 0.267 | 0.202 | 0.165 | 0.122 | 0.085 | 0.062 | 0.054 | 0.048 | 0.046 | 0.046 | 0.048 | |||
BSA | 0.151 | 0.072 | 0.054 | 0.054 | 0.047 | 0.048 | 0.047 | 0.049 | 0.043 | 0.044 | 0.065 | 0.044 | ||
0.157 | 0.073 | 0.053 | 0.051 | 0.047 | 0.052 | 0.045 | 0.048 | 0.045 | 0.046 | 0.046 | 0.047 | |||
350.5.7.1D10 | RBD | 2.536 | 2.476 | 2.481 | 2.395 | 2.504 | 2.362 | 2.009 | 1.301 | 0.592 | 0.266 | 0.115 | 0.069 | |
2.476 | 2.347 | 2.459 | 2.427 | 2.4 | 2.292 | 1.873 | 1.095 | 0.506 | 0.195 | 0.092 | 0.061 | |||
Spike | 2.09 | 2.156 | 2.051 | 2.075 | 1.989 | 1.795 | 1.445 | 0.856 | 0.343 | 0.137 | 0.074 | 0.056 | ||
2.027 | 2.043 | 2.059 | 2.095 | 1.92 | 1.819 | 1.351 | 0.752 | 0.321 | 0.14 | 0.075 | 0.054 | |||
BSA | 0.062 | 0.048 | 0.046 | 0.047 | 0.043 | 0.048 | 0.048 | 0.046 | 0.043 | 0.045 | 0.044 | 0.043 | ||
0.069 | 0.053 | 0.047 | 0.045 | 0.044 | 0.045 | 0.05 | 0.045 | 0.043 | 0.044 | 0.046 | 0.045 | |||
350.5.7.1F05 | RBD | 2.498 | 2.463 | 2.413 | 2.394 | 2.371 | 2.239 | 2.022 | 1.425 | 0.724 | 0.319 | 0.146 | 0.085 | |
2.414 | 2.434 | 2.39 | 2.359 | 2.341 | 2.328 | 1.999 | 1.369 | 0.664 | 0.291 | 0.129 | 0.076 | |||
Spike | 2.178 | 2.095 | 2.059 | 2.006 | 1.986 | 1.817 | 1.529 | 0.885 | 0.386 | 0.156 | 0.082 | 0.09 | ||
2.166 | 2.066 | 2.085 | 2.115 | 1.963 | 1.826 | 1.486 | 0.786 | 0.515 | 0.138 | 0.078 | 0.061 | |||
BSA | 0.211 | 0.092 | 0.055 | 0.047 | 0.047 | 0.061 | 0.051 | 0.049 | 0.043 | 0.043 | 0.044 | 0.047 | ||
0.259 | 0.116 | 0.058 | 0.05 | 0.052 | 0.085 | 0.049 | 0.048 | 0.043 | 0.083 | 0.044 | 0.052 |