Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual revascularization surgeries in the US, there is need for an improved, non-invasive technique to quantitatively assess LV contractile function.
Technology Description: A team led by Dr. Michael Pasque has developed cardiac MRI-based multiparametric strain analysis techniques to provide quantitative assessments of LV contractile function. The patented techniques and Normal Human Strain Database may be used as a screening mechanism to non-invasively assess heart function or to assess cardiac tissue viability to inform revascularization surgeries.
Key Advantages:
- Uses non-invasive MRI imaging to assess heart function
- Provides an objective, quantitative measure of LV contractile function
- Provides localized information
Publications:
- Henn, M. C., Cupps, B. P., Kar, J., Kulshrestha, K., Koerner, D., Braverman, A. C., & Pasque, M. K. (2015). Quantifying “normalized” regional left ventricular contractile function in ischemic coronary artery disease. The Journal of thoracic and cardiovascular surgery, 150(1), 240-246.
- Kar, J., Knutsen, A. K., Cupps, B. P., Zhong, X., & Pasque, M. K. (2015). Three‐dimensional regional strain computation method with displacement encoding with stimulated echoes (DENSE) in non‐ischemic, non‐valvular dilated cardiomyopathy patients and healthy subjects validated by tagged MRI. Journal of Magnetic Resonance Imaging, 41(2), 386-396.
- Cupps, B. P., Taggar, A. K., Reynolds, L. M., Lawton, J. S., & Pasque, M. K. (2010). Regional myocardial contractile function: multiparametric strain mapping. Interactive cardiovascular and thoracic surgery, 10(6), 953-957.
- Henn, M. C., Lawrance, C. P., Kar, J., Cupps, B. P., Kulshrestha, K., Koerner, D., … & Pasque, M. K. (2015). Dilated cardiomyopathy: normalized multiparametric myocardial strain predicts contractile recovery. The Annals of thoracic surgery, 100(4), 1284-1291.
Intellectual Property:
- Method for quantitatively mapping myocardial contractile function with magnetic resonance based multiparametric strain analysis (US Patent No. 9,176,211; WUSTL Case #T006692)
- Systems and methods for measuring cardiac strain (Published PCT WO2016065159, Allowed claims in the U.S.; WUSTL Case #T014564)
