[¹⁸F]WC-DZ-F is a derivative of [¹⁸F]FluorThanatrace and a radiotherapeutic agent. [¹⁸F]WC-DZ-F has suitable biodistribution profile, favourable logP and super metabolic stability in vivo. We have demonstrated that [¹⁸F]WC-DZ-F is capable of imaging PARP-1 expression in PC-3 prostate cancer xenograft tumor in small animal. [¹⁸F]WC-DZ-F can be a replacement of [¹⁸F]FluorThanatrace in the imaging of PARP-1 expression.