— Published date: 1/6/2025
Value Proposition: Stabilization of glycoprotein of Bourbon Virus (BRBV) and related thogotoviruses as a key target for vaccine and antiviral development.
Technology Description
Researchers at Washington University in St. Louis have determined the pre-fusion structure…
— Influenza virus containing a GFP reporter gene in one of the gene-segments. It allows for high throughput screening of compounds or host factors required for influenza virus infection and replication.
— This strain of the Bourbon virus was isolated from the serum of an infected St. Louis-area patient. The isolated virus was used to demonstrate in vitro and in a mouse model that the antiviral drug favipiravir has prophylactic and therapeutic efficacy against the Bourbon virus, indicating it as a goo…
— CRISPR-Cas9 gene editing was used to modify the coding region of the SAMD9L mouse gene. The genetic modification resulted in the deletion of the full length production of the protein. This modification was made in a C57BL/6 genetic background.
— A plasmid based reverse genetics system for Bourbon virus was created. This system and related plasmids allow for the creation of infectious Bourbon virus and evaluate the impact of genetic variation on the virus (replication, disease, antibody-mediated neutralization etc.). It also allows for the c…
— CRISPR-Cas9 gene editing was used to modify the coding region of the MAP3K6 mouse gene. The genetic modification resulted in the deletion of the full length production of the protein. This modification was made in a C57BL/6J genetic background. MAP3K6 is a signaling molecule and could be the target …
| Name | # Summaries | Author |
|---|---|---|
| 15 | ||
| 13 | ||
| 15 | ||
| 26 | ||
| 14 | ||
| 14 |
Creating...
