— Published date: 6/3/2026
Value Proposition: Using CLCA1 VWA to specifically potentiate TMEM16A to enhance mucociliary transport in cystic fibrosis and other mucus obstructive diseases.
Technology Description
Researchers at Washington University in St. Louis have developed a potentiator, CLCA1 …
— Stable zebrafish line that shows calcium signaling within the pancreatic beta cells. The line was generated using the calcium sensing fluorophore gCAMP and integrated using the TOL2 transcription factor.
Publication: Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets
— This is a CRISPR/Cas9 germline mutation in the KCNJ8 gene, equivalent to a human Cantu Syndrome mutation. The mouse is therefore a genetic model of human Cantu Syndrome. This mouse model can be used for pre-clinical testing of targeted therapy for Cantu Syndrome.
Publication: Cardiovascular consequ…
— This mouse model was generated by using CRISPR/Cas9 to mutate the ABCC9 gene. The mouse model described here could be used as a pre-clinical model for testing Cantu Syndrome therapies.
Publication: Cardiovascular consequences of KATP overactivity in Cantu syndrome
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