by | Oct 22, 2019 | Mennerick, Steven, Sun, Min-Yu, Taylor, Amanda, Zorumski, Charles
— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases
Drug format – neurosteroid
Drug class – drug repurposing (25-hydroxycholesterol)
Research stage and Preliminary data:
In vitro – The inventors demonstrated…
by | Oct 22, 2019 | Apte, Rajendra
— Technology Description
Researchers in Prof. Rajendra Apte’s laboratory developed novel methods for treating macular degeneration and other eye diseases by targeting a cholesterol transport pathway involved in the formation of new blood vessels. Age-related macular degeneration (AMD) is a lea…
by | Oct 22, 2019 | Abernathy, Daniel, Yoo, Andrew
— Background: Studying late-onset neurodegenerative disorders using patient-specific neurons is one of the primary goals of precision medicine. The ability to generate human neurons that mimic the neurons of elderly individuals will provide an instrumental platform to model and study adult-onset neuro…
by | Oct 22, 2019 | Berezin, Mikhail, Binkley, Michael, Meacham, John
— Technology Description:
Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices.
Applications:
1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…
by | Jun 7, 2018 | Shaikh, Nurmohammad, Tarr, Phillip
— Primary Inventor: Phillip I. Tarr, MD
Target: GelE(mAb 8A3)
Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…