— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…
— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…
— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…
— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…
— Background: Allogeneic hematopoietic stem-cell transplantation (aHSCT) from a healthy donor can cure a variety of blood cell disorders including leukemia, multiple myeloma, and some types of lymphoma. This has resulted in an increasing number of transplants, surpassing 8,000 a year in the US alone. …
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