— Mouse model for Niemann-Pick C1 (NPC1) disease
This mouse model was generated by CRISPR KI of the P1007A mutation into the NPC1 protein. Mice heterozygous or homozygous for this mutation do not have an apparent phenotype. However, when the heterozgous P1007A mouse is crossed with the NPC1 I1061T m…
— Lyz2Cre;Talin-1fl/fl mouse strain
Inventors crossed Talin-1fl/fl mice (received from Oklahoma Medical Research Foundation) with Lyz2Cre mice (available at the Jackson Laboratory) to generate Lyz2Cre;Talin-1fl/fl mice.
— This is a trangenic mouse with the floxed Stat1 gene. This mouse can be breed with whole body or tissue specific Cre lines to knockout out STAT1 – which is a transcription factor that is essential for the interferon signaling pathway.
Publication: Respiratory Enterovirus (Like Parainfluenza Virus)…
— This expression plasmid can be used to identify inhibitors for Keap1 – a pathway that is invoIved in oxidative stress response and implicated in Marburg virus infection.
Publication: Dimerization controls Marburg virus VP24-dependent modulation of host antioxidative stress responses
— Plasmids for luciferase expression in Cryptosporidium
The plasmids listed below are for targeting insertion into the TK and UPRT loci in Cryptosporidium parvum. To generate the plasmids, the inventors modified a previously described nanoluciferase (Nluc) reporter fused to neomycin resistance (NeoR)…
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