Murine Hybridoma producing IgG1 Monoclonal Antibody to Human SIRP-B2

— Target: Cluster of Differentiation 172g protein, a.k.a. Signal Regulatory Protein Beta-2.

Notes: Clone name is LSB2.20.

Monoclonal antibodies were raised in a 4-to 8 week-old female Balb/c mouse by immunozation with a recombinant GST fusion protein containing the whole extracellular domain of SIRPB1. These can be used to study T-cell activation and the induction of antigen-specific cytotoxic T-lymphocyte responses by…

Grp Floxed mouse strain

— Grp floxed mouse strain

These mice have loxP sites flanking exon 1 of the Grp gene. It was used to study the mechanism of itch and further interrogation of itch-nerve fibers in the skin under chronic pruritus.

Publication: Exploration of Sensory and Spinal Neurons Expressing GRP in Itch and Pain

Grpr Flox Mouse Strain

— Grpr floxed mouse strain

This mouse strain has loxP sites flanking exon 2 of the Grpr gene. Inventors backcrossed the mice into the C57Bl/6J background. The mouse strain was used to study contagious itch and demonstrated that GRP-GRPR signaling is necessary and sufficient for transmitting contagiou…

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD155 (PVR)

— Target: CD155 is a adhesion receptor, orginally known as the cellular receptor for Polio Virus.

Notes: Clone name is SK II 4.3

Information on antibody against poliovirus receptor (CD155)

Herein, we describe the generation of a murine antibody that recognizes poliovirus receptor (CD155). We made this antibody by immunizing mice with SK-N-S1 human neuroblastoma cells. We then validated this antibody using flow cytometry.

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD96 (Tactile)

— Target: CD96 is a T cell-specific receptor indicative of T cell activation.

Notes: Clone name NK92.39.1. For use in flow cytometry.

Researchers generated the antibodies by immunizing mice with NK92 cells and selected hybridomas that plocked binding of PVR to NK92. These antibodies have been used to study natural killer cell target cell adhesion.

Publication: Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by …

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